Aplastic anemia laboratory findings: Difference between revisions
Jump to navigation
Jump to search
Shyam Patel (talk | contribs) |
|||
| (27 intermediate revisions by 6 users not shown) | |||
| Line 1: | Line 1: | ||
__NOTOC__ | |||
{{Aplastic anemia}} | {{Aplastic anemia}} | ||
'''Editor-In-Chief:''' | {{CMG}} {{shyam}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.D.]] [mailto:psingh13579@gmail.com] {{N.F}} | ||
==Overview== | ==Overview== | ||
Patients with [[aplastic anemia]] have a hypoplastic bone marrow (<20% cellularity), [[pancytopenia]] | Patients with [[aplastic anemia]] have a hypoplastic bone marrow (<20% cellularity), [[pancytopenia]], transfusion-dependent anemia, [[thrombocytopenia]], severe [[neutropenia]]), low [[reticulocyte count]], and normal maturation of all cell lines. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
=== | Laboratory findings consistent with the diagnosis of aplastic anemia include: | ||
* [[ | |||
* [[Renal function]] | ===Complete blood count (CBC)=== | ||
* [[ | * Decreased [[hemoglobin]] | ||
* Decreased [[hematocrit]] | |||
* Decreased [[white blood cell]] count | |||
* Decreased [[platelet count]] | |||
===Reticulocyte count=== | |||
* Decreased reticulocyte count ([[reticulocytopenia]]) | |||
=== Peripheral blood smear === | |||
* [[Macrocytosis]] | |||
* [[Poikilocytosis]] | |||
* Small-sized [[platelet|platelets]] | |||
===Other tests=== | |||
The following tests should be performed to rule out other conditions: | |||
* [[Renal function]] | |||
* [[Basic metabolic panel]] | |||
* [[Liver enzyme]]s | * [[Liver enzyme]]s | ||
* [[Thyroid]] function tests | * [[Thyroid]] function tests | ||
* [[ | * Viral studies | ||
* [[Vitamin B12]] and [[folic acid]] levels | |||
===Bone marrow aspiration and biopsy=== | |||
* Hypocellular bone marrow with increased [[adipose tissue]] and decreased [[hematopoietic cell|hematopoietic cells]] in the marrow space<ref name="pmid22517900">{{cite journal| author=Scheinberg P, Young NS| title=How I treat acquired aplastic anemia. | journal=Blood | year= 2012 | volume= 120 | issue= 6 | pages= 1185-96 | pmid=22517900 | doi=10.1182/blood-2011-12-274019 | pmc=3418715 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22517900 }} </ref> | |||
* Normal maturation of all [[cell]] lines | |||
==References== | ==References== | ||
Latest revision as of 02:50, 3 December 2018
|
Aplastic anemia Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Aplastic anemia laboratory findings On the Web |
|
American Roentgen Ray Society Images of Aplastic anemia laboratory findings |
|
Risk calculators and risk factors for Aplastic anemia laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [3] Nazia Fuad M.D.
Overview
Patients with aplastic anemia have a hypoplastic bone marrow (<20% cellularity), pancytopenia, transfusion-dependent anemia, thrombocytopenia, severe neutropenia), low reticulocyte count, and normal maturation of all cell lines.
Laboratory Findings
Laboratory findings consistent with the diagnosis of aplastic anemia include:
Complete blood count (CBC)
- Decreased hemoglobin
- Decreased hematocrit
- Decreased white blood cell count
- Decreased platelet count
Reticulocyte count
- Decreased reticulocyte count (reticulocytopenia)
Peripheral blood smear
- Macrocytosis
- Poikilocytosis
- Small-sized platelets
Other tests
The following tests should be performed to rule out other conditions:
- Renal function
- Basic metabolic panel
- Liver enzymes
- Thyroid function tests
- Viral studies
- Vitamin B12 and folic acid levels
Bone marrow aspiration and biopsy
- Hypocellular bone marrow with increased adipose tissue and decreased hematopoietic cells in the marrow space[1]
- Normal maturation of all cell lines
References
- ↑ Scheinberg P, Young NS (2012). "How I treat acquired aplastic anemia". Blood. 120 (6): 1185–96. doi:10.1182/blood-2011-12-274019. PMC 3418715. PMID 22517900.