Human respiratory syncytial virus future or investigational therapies: Difference between revisions
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Latest revision as of 18:04, 18 September 2017
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Human respiratory syncytial virus Microchapters |
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Differentiating Human Respiratory Syncytial Virus from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Human respiratory syncytial virus future or investigational therapies On the Web |
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American Roentgen Ray Society Images of Human respiratory syncytial virus future or investigational therapies |
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FDA on Human respiratory syncytial virus future or investigational therapies |
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Human respiratory syncytial virus future or investigational therapies in the news |
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Blogs on Human respiratory syncytial virus future or investigational therapies |
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Directions to Hospitals Treating Human respiratory syncytial virus |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Future or Investigational Therapies
Amino acid sequences 200-225 and 255-278 of the F protein of human respiratory syncytial virus (HRSV) are T cell epitopes (Bourgeois et al., 1991; Corvaisier et al, 1993). Peptides corresponding to these two regions were synthesized and coupled with keyhole limpet haemocyanin (KLH). The two conjugated proteins were administered intranasally to BALB/c mice alone or together with cholera toxin B (CTB). ELISAs revealed that the mixture of the conjugates with CTB increased not only the systemic response but also the mucosal immune response of the saliva. The systemic response was lower and the mucosal immune response was undetectable in mice immunized with the conjugates on their own. These results suggest that these two peptide sequences are effective epitopes for inducing systemic and mucosal immune responses in conjunction with CTB, and may provide the basis for a nasal peptide vaccine against RSV for human use. [2]