Fever of unknown origin causes: Difference between revisions
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| style="vertical-align: middle; padding: 5px;" align="center" |[[File:Siren.gif|30px|link=Fever of unknown origin resident survival guide]] | |||
| style="vertical-align: middle; padding: 5px;" align="center" |[[Fever of unknown origin resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']] | |||
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{{Fever of unknown origin}} | {{Fever of unknown origin}} | ||
{{CMG}} | {{CMG}}; {{AE}} [[User:Naresh Mullaguri|Naresh Mullaguri, M.B.B.S.]] [mailto:mullaguri.nari@gmail.com] | ||
{{SK}} febris continua e causa ignota; febris e causa ignota; febris E.C.I.; FUO; PUO; pyrexia of unknown origin | |||
==Overview== | ==Overview== | ||
Classic FUO may be caused by infection, neoplasia, inflammatory , miscellaneous diseases, and undiagnosed illness.Common causes of neutropenic FUO include bacterial, fungal and viral infection.Causes of nosocomial FUO are related to hospital setting such as drugs, infections acquired during hospitalization and complications that occur during and after surgery.This may due to acute infection from HIV itself earlier or later due to [[Opportunistic infection|opportunistic]] bacterial, fungal and viral infections such as [[mycobacteria]], [[Toxoplasmosis|toxoplasma]] etc. | |||
==Causes== | |||
Etiology is different for different categories of FUO: | |||
===Classic FUO=== | |||
| | #Malignancies such as [[Hodgkin's lymphoma|Hodgkin]] and [[Non-Hodgkin lymphoma|non-Hodgkin]] lymphoma, [[Myeloproliferative neoplasm|myeloproliferative]] disorders, [[colorectal carcinoma]] and carcinoma of liver. | ||
#Infections such as intrabdominal and pelvic [[abscesses]], inflammation of the endocardium, [[tuberculosis]], [[cat scratch disease]], [[CMV infection|CMV]] and [[Epstein Barr virus|EBV]] infections. | |||
#Inflammatory causes such as autoimmune diseases ([[systemic lupus erythematosus]], [[Rheumatoid arthritis]]) and [[polymyalgia rheumatica]].<ref name="HayakawaRamasamy2012">{{cite journal|last1=Hayakawa|first1=Kayoko|last2=Ramasamy|first2=Balaji|last3=Chandrasekar|first3=Pranatharthi H.|title=Fever of Unknown Origin: An Evidence-Based Review|journal=The American Journal of the Medical Sciences|volume=344|issue=4|year=2012|pages=307–316|issn=00029629|doi=10.1097/MAJ.0b013e31824ae504}}</ref> | |||
#Miscellaneous such as Medication/drug fever,Hyperthyroidism Hematoma,Chronic pulmonary.<ref name="pmid32462043">{{cite journal| author=Wright WF, Auwaerter PG| title=Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma. | journal=Open Forum Infect Dis | year= 2020 | volume= 7 | issue= 5 | pages= ofaa132 | pmid=32462043 | doi=10.1093/ofid/ofaa132 | pmc=7237822 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=32462043 }} </ref> | |||
===Neutropenic FUO=== | |||
These are mostly caused by bacterial, fungal and viral infection because of the decreased neutrophil count.<ref name="HayakawaRamasamy20122">{{cite journal|last1=Hayakawa|first1=Kayoko|last2=Ramasamy|first2=Balaji|last3=Chandrasekar|first3=Pranatharthi H.|title=Fever of Unknown Origin: An Evidence-Based Review|journal=The American Journal of the Medical Sciences|volume=344|issue=4|year=2012|pages=307–316|issn=00029629|doi=10.1097/MAJ.0b013e31824ae504}}</ref> | |||
|- | ===HIV associated FUO=== | ||
This may due to acute infection from HIV itself earlier or later due to [[Opportunistic infection|opportunistic]] bacterial, fungal and viral infections such as [[mycobacteria]], [[Toxoplasmosis|toxoplasma]] etc.<ref name="HayakawaRamasamy20123">{{cite journal|last1=Hayakawa|first1=Kayoko|last2=Ramasamy|first2=Balaji|last3=Chandrasekar|first3=Pranatharthi H.|title=Fever of Unknown Origin: An Evidence-Based Review|journal=The American Journal of the Medical Sciences|volume=344|issue=4|year=2012|pages=307–316|issn=00029629|doi=10.1097/MAJ.0b013e31824ae504}}</ref> | |||
===Nosocomial FUO=== | |||
Causes of nosocomial FUO are related to hospital setting such as drugs, infections acquired during hospitalization and complications that occur during and after surgery.<ref name="pmid32462043">{{cite journal| author=Wright WF, Auwaerter PG| title=Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma. | journal=Open Forum Infect Dis | year= 2020 | volume= 7 | issue= 5 | pages= ofaa132 | pmid=32462043 | doi=10.1093/ofid/ofaa132 | pmc=7237822 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=32462043 }}</ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | |||
[[Category:Ailments of unknown etiology]] | |||
[[Category: | |||
Latest revision as of 16:40, 26 January 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Naresh Mullaguri, M.B.B.S. [2]
Synonyms and keywords: febris continua e causa ignota; febris e causa ignota; febris E.C.I.; FUO; PUO; pyrexia of unknown origin
Overview
Classic FUO may be caused by infection, neoplasia, inflammatory , miscellaneous diseases, and undiagnosed illness.Common causes of neutropenic FUO include bacterial, fungal and viral infection.Causes of nosocomial FUO are related to hospital setting such as drugs, infections acquired during hospitalization and complications that occur during and after surgery.This may due to acute infection from HIV itself earlier or later due to opportunistic bacterial, fungal and viral infections such as mycobacteria, toxoplasma etc.
Causes
Etiology is different for different categories of FUO:
Classic FUO
- Malignancies such as Hodgkin and non-Hodgkin lymphoma, myeloproliferative disorders, colorectal carcinoma and carcinoma of liver.
- Infections such as intrabdominal and pelvic abscesses, inflammation of the endocardium, tuberculosis, cat scratch disease, CMV and EBV infections.
- Inflammatory causes such as autoimmune diseases (systemic lupus erythematosus, Rheumatoid arthritis) and polymyalgia rheumatica.[1]
- Miscellaneous such as Medication/drug fever,Hyperthyroidism Hematoma,Chronic pulmonary.[2]
Neutropenic FUO
These are mostly caused by bacterial, fungal and viral infection because of the decreased neutrophil count.[3]
HIV associated FUO
This may due to acute infection from HIV itself earlier or later due to opportunistic bacterial, fungal and viral infections such as mycobacteria, toxoplasma etc.[4]
Nosocomial FUO
Causes of nosocomial FUO are related to hospital setting such as drugs, infections acquired during hospitalization and complications that occur during and after surgery.[2]
References
- ↑ Hayakawa, Kayoko; Ramasamy, Balaji; Chandrasekar, Pranatharthi H. (2012). "Fever of Unknown Origin: An Evidence-Based Review". The American Journal of the Medical Sciences. 344 (4): 307–316. doi:10.1097/MAJ.0b013e31824ae504. ISSN 0002-9629.
- ↑ 2.0 2.1 Wright WF, Auwaerter PG (2020). "Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma". Open Forum Infect Dis. 7 (5): ofaa132. doi:10.1093/ofid/ofaa132. PMC 7237822 Check
|pmc=
value (help). PMID 32462043 Check|pmid=
value (help). - ↑ Hayakawa, Kayoko; Ramasamy, Balaji; Chandrasekar, Pranatharthi H. (2012). "Fever of Unknown Origin: An Evidence-Based Review". The American Journal of the Medical Sciences. 344 (4): 307–316. doi:10.1097/MAJ.0b013e31824ae504. ISSN 0002-9629.
- ↑ Hayakawa, Kayoko; Ramasamy, Balaji; Chandrasekar, Pranatharthi H. (2012). "Fever of Unknown Origin: An Evidence-Based Review". The American Journal of the Medical Sciences. 344 (4): 307–316. doi:10.1097/MAJ.0b013e31824ae504. ISSN 0002-9629.