Subdural hematoma medical therapy: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Subdural hematoma}} | {{Subdural hematoma}} | ||
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==Overview== | ==Overview== | ||
Surgery is the mainstay of treatment for subdural hematoma. Pharmacologic medical therapies for subdural hematoma include corticosteroids, atorvastatin, tranexamic acid, etizolam, and ACE inhibitor. | |||
==Medical Therapy== | |||
* Surgery is the mainstay of treatment for subdural hematoma. | |||
*Pharmacologic medical therapies for subdural hematoma include corticosteroids, atorvastatin, tranexamic acid, etizolam, and ACE inhibitor.<ref name="ThotakuraMarabathina2018">{{cite journal|last1=Thotakura|first1=AmitKumar|last2=Marabathina|first2=NageswaraRao|title=The role of medical treatment in chronic subdural hematoma|journal=Asian Journal of Neurosurgery|volume=13|issue=4|year=2018|pages=976|issn=1793-5482|doi=10.4103/ajns.AJNS_13_17}}</ref><ref name="Ostermannvon Heymann2019">{{cite journal|last1=Ostermann|first1=Helmut|last2=von Heymann|first2=Christian|title=Prothrombin complex concentrate for vitamin K antagonist reversal in acute bleeding settings: efficacy and safety|journal=Expert Review of Hematology|year=2019|issn=1747-4086|doi=10.1080/17474086.2019.1624520}}</ref><ref name="VornicuLarock2017">{{cite journal|last1=Vornicu|first1=Ovidiu|last2=Larock|first2=Anne-Sophie|last3=Dincq|first3=Anne-Sophie|last4=Douxfils|first4=Jonathan|last5=Dogné|first5=Jean-Michel|last6=Mullier|first6=François|last7=Lessire|first7=Sarah|title=Idarucizumab for the treatment of hemorrhage and dabigatran reversal in patients requiring urgent surgery or procedures|journal=Expert Opinion on Biological Therapy|volume=17|issue=10|year=2017|pages=1275–1296|issn=1471-2598|doi=10.1080/14712598.2017.1349749}}</ref><ref name="PowellTaylor2019">{{cite journal|last1=Powell|first1=Jason|last2=Taylor|first2=James|last3=Garland|first3=Scott G.|title=Andexanet alfa: A Novel Factor Xa Inhibitor Reversal Agent|journal=Annals of Pharmacotherapy|year=2019|pages=106002801983520|issn=1060-0280|doi=10.1177/1060028019835209}}</ref><ref name="DerbalahDuffull2019">{{cite journal|last1=Derbalah|first1=Abdallah|last2=Duffull|first2=Stephen|last3=Newall|first3=Fiona|last4=Moynihan|first4=Katie|last5=Al-Sallami|first5=Hesham|title=Revisiting the Pharmacology of Unfractionated Heparin|journal=Clinical Pharmacokinetics|year=2019|issn=0312-5963|doi=10.1007/s40262-019-00751-7}}</ref> | |||
*In patients with anticoagulation problem we have to correct the coagulation system: | |||
**Prothrombin complex concentrate (PCC) for patients who use warfarin or other vitamin K antagonist (VKA) | |||
**Idarucizumab for patients who use dabigatran | |||
**Andexanet alfa for patients who use direct factor Xa inhibitor | |||
**Protamine sulfate for patients who use heparin | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category: (name of the system)]] | |||
Latest revision as of 12:43, 11 June 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.
Overview
Surgery is the mainstay of treatment for subdural hematoma. Pharmacologic medical therapies for subdural hematoma include corticosteroids, atorvastatin, tranexamic acid, etizolam, and ACE inhibitor.
Medical Therapy
- Surgery is the mainstay of treatment for subdural hematoma.
- Pharmacologic medical therapies for subdural hematoma include corticosteroids, atorvastatin, tranexamic acid, etizolam, and ACE inhibitor.[1][2][3][4][5]
- In patients with anticoagulation problem we have to correct the coagulation system:
- Prothrombin complex concentrate (PCC) for patients who use warfarin or other vitamin K antagonist (VKA)
- Idarucizumab for patients who use dabigatran
- Andexanet alfa for patients who use direct factor Xa inhibitor
- Protamine sulfate for patients who use heparin
References
- ↑ Thotakura, AmitKumar; Marabathina, NageswaraRao (2018). "The role of medical treatment in chronic subdural hematoma". Asian Journal of Neurosurgery. 13 (4): 976. doi:10.4103/ajns.AJNS_13_17. ISSN 1793-5482.
- ↑ Ostermann, Helmut; von Heymann, Christian (2019). "Prothrombin complex concentrate for vitamin K antagonist reversal in acute bleeding settings: efficacy and safety". Expert Review of Hematology. doi:10.1080/17474086.2019.1624520. ISSN 1747-4086.
- ↑ Vornicu, Ovidiu; Larock, Anne-Sophie; Dincq, Anne-Sophie; Douxfils, Jonathan; Dogné, Jean-Michel; Mullier, François; Lessire, Sarah (2017). "Idarucizumab for the treatment of hemorrhage and dabigatran reversal in patients requiring urgent surgery or procedures". Expert Opinion on Biological Therapy. 17 (10): 1275–1296. doi:10.1080/14712598.2017.1349749. ISSN 1471-2598.
- ↑ Powell, Jason; Taylor, James; Garland, Scott G. (2019). "Andexanet alfa: A Novel Factor Xa Inhibitor Reversal Agent". Annals of Pharmacotherapy: 106002801983520. doi:10.1177/1060028019835209. ISSN 1060-0280.
- ↑ Derbalah, Abdallah; Duffull, Stephen; Newall, Fiona; Moynihan, Katie; Al-Sallami, Hesham (2019). "Revisiting the Pharmacology of Unfractionated Heparin". Clinical Pharmacokinetics. doi:10.1007/s40262-019-00751-7. ISSN 0312-5963.