Small cell carcinoma of the lung physical examination: Difference between revisions
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==Overview== | ==Overview== | ||
Many authors have concluded that performing a complete assessment, with a detailed history and physical examination, is useful for identifying patients with a higher likelihood of [[metastases]]. | Many authors have concluded that performing a complete assessment, with a detailed history and [[physical examination]], is useful for identifying patients with a higher likelihood of [[metastases]]. Fever is reported in 20% of the patients. Patients may present with [[Weight loss|weight loss,]] [[cachexia]] and [[anorexia]]. Upon [[auscultation]] unilateral decreased air entry, unilateral [[wheeze]], and decreased air entry in the bases of the [[lungs]] and/or [[crackles]] (suggestive of [[pleural effusion]]) may be present. The [[musculoskeletal system]] may show the signs of [[digital clubbing]], [[bone]] [[tenderness]], (suggestive of [[bone]] [[metastasis]]) and [[osteoarthropathy]] may be noted. | ||
==Physical Examination | ==Physical Examination== | ||
The [[physical examination]] findings of small cell lung cancer are described below:<ref name="pmid21565397">{{cite journal| author=van Meerbeeck JP, Fennell DA, De Ruysscher DK| title=Small-cell lung cancer. | journal=Lancet | year= 2011 | volume= 378 | issue= 9804 | pages= 1741-55 | pmid=21565397 | doi=10.1016/S0140-6736(11)60165-7 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21565397 }} </ref><ref name="pmid18316005">{{cite journal| author=Sher T, Dy GK, Adjei AA| title=Small cell lung cancer. | journal=Mayo Clin Proc | year= 2008 | volume= 83 | issue= 3 | pages= 355-67 | pmid=18316005 | doi=10.4065/83.3.355 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18316005 }} </ref><ref name="pmid17873166">{{cite journal |vauthors=Spiro SG, Gould MK, Colice GL |title=Initial evaluation of the patient with lung cancer: symptoms, signs, laboratory tests, and paraneoplastic syndromes: ACCP evidenced-based clinical practice guidelines (2nd edition) |journal=Chest |volume=132 |issue=3 Suppl |pages=149S–160S |date=September 2007 |pmid=17873166 |doi=10.1378/chest.07-1358 |url=}}</ref> | |||
=== | ===Appearance of the Patient=== | ||
*[[Cachexia]] ([[weight loss]] and [[anorexia]]) may be present | *[[Cachexia]] ([[weight loss]] and [[anorexia]]) may be present | ||
* Central [[obesity]] (suggestive of [[Cushing's syndrome]]) may be present | * Central [[obesity]] (suggestive of [[Cushing's syndrome]]) may be present | ||
| Line 24: | Line 21: | ||
* [[Dehydration]] (suggestive of [[hypercalcemia]]) may be present | * [[Dehydration]] (suggestive of [[hypercalcemia]]) may be present | ||
=== | ===Vital Signs=== | ||
* | *[[Fever]] (in up to 20% of the patients) | ||
*[[Hypertension]] (can be present in case of [[Cushing's syndrome]]) | |||
* | |||
===Skin=== | |||
< | * Acquired [[tylosis]] may be present | ||
*[[Tripe palms]] may be present<ref name="pmid8638207">{{cite journal| author=Mullans EA, Cohen PR| title=Tripe palms: a cutaneous paraneoplastic syndrome. | journal=South Med J | year= 1996 | volume= 89 | issue= 6 | pages= 626-7 | pmid=8638207 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8638207 }} </ref> | |||
*[[Erythema gyratum repens]] (rare) | |||
</ | |||
===HEENT=== | |||
*[[Moon facies]] (suggestive of [[Cushing's syndrome]]) may be present | |||
*[[Swelling]] of the face, neck, trunk, and arms (suggestive of [[superior vena cava syndrome]]) may be present | |||
*Yellow discoloration of the [[sclera]] (suggestive of [[jaundice]] due to liver [[metastasis]]) may be present | |||
* Conjunctival [[pallor]] (suggestive of [[anemia of chronic disease]]) may be present | |||
*[[Miosis]], ipsilateral [[ptosis]] and lack of [[facial]] sweating (suggestive of [[Horner's syndrome]]) may be present | |||
*[[Hoarseness]] ( suggestive of compression of the [[recurrent laryngeal nerve]]) may be present | *[[Hoarseness]] ( suggestive of compression of the [[recurrent laryngeal nerve]]) may be present | ||
===Neck=== | |||
* [[Swelling]] | |||
===Lungs=== | ===Lungs=== | ||
* Unilateral decreased air entry may be present | * Unilateral decreased air entry may be present | ||
* Unilateral [[wheeze]] may be present | * Unilateral [[wheeze]] may be present | ||
* Decreased air entry in the bases of the lungs and/or [[crackles]] (suggestive of [[ | * Decreased air entry in the bases of the [[lungs]] and/or [[crackles]] (suggestive of [[pleural effusion]]) may be present | ||
===Heart=== | |||
* [[Circulatory system|Cardiovascular]] [[Physical examination|examination]] of [[Patient|patients]] with small cell lung cancer is usually normal | |||
===Abdomen=== | ===Abdomen=== | ||
*[[Hepatomegaly]] (> 13 cm span) (suggestive of liver [[metastasis]]) may be present | *[[Hepatomegaly]] (> 13 cm span) (suggestive of liver [[metastasis]]) may be present | ||
=== | ===Back=== | ||
* [[Human back|Back]] examination of [[Patient|patients]] with small cell lung cancer is usually normal | |||
*[[ | |||
===Genitourinary=== | |||
* [[Genitourinary system|Genitourinary]] [[Physical examination|examination]] of [[Patient|patients]] with small cell lung cancer is usually normal | |||
=== | ===Neuromuscular=== | ||
* [[Weakness]] of the proximal muscles of lower extremities, abnormal [[gait]], [[autonomic dysfunction]], and [[paresthesia]] (suggestive of [[Lambert-Eaton syndrome]]) may be present<ref name="pmid21565397">{{cite journal| author=van Meerbeeck JP, Fennell DA, De Ruysscher DK| title=Small-cell lung cancer. | journal=Lancet | year= 2011 | volume= 378 | issue= 9804 | pages= 1741-55 | pmid=21565397 | doi=10.1016/S0140-6736(11)60165-7 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21565397 }} </ref> | *[[Weakness]] of the proximal [[muscles]] of [[lower extremities]], abnormal [[gait]], [[autonomic dysfunction]], and [[paresthesia]] (suggestive of [[Lambert-Eaton syndrome]]) may be present<ref name="pmid21565397">{{cite journal| author=van Meerbeeck JP, Fennell DA, De Ruysscher DK| title=Small-cell lung cancer. | journal=Lancet | year= 2011 | volume= 378 | issue= 9804 | pages= 1741-55 | pmid=21565397 | doi=10.1016/S0140-6736(11)60165-7 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21565397 }} </ref> | ||
* [[Altered mental status]], [[seizures]], [[memory loss]], space and time [[disorientation]], with or without [[dementia]] (suggestive of [[limbic encephalitis]] and [[encephalomyelitis]]) may occur<ref name="pmid21565397">{{cite journal| author=van Meerbeeck JP, Fennell DA, De Ruysscher DK| title=Small-cell lung cancer. | journal=Lancet | year= 2011 | volume= 378 | issue= 9804 | pages= 1741-55 | pmid=21565397 | doi=10.1016/S0140-6736(11)60165-7 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21565397 }} </ref> | * [[Altered mental status]], [[seizures]], [[memory loss]], space and time [[disorientation]], with or without [[dementia]] (suggestive of [[limbic encephalitis]] and [[encephalomyelitis]]) may occur<ref name="pmid21565397">{{cite journal| author=van Meerbeeck JP, Fennell DA, De Ruysscher DK| title=Small-cell lung cancer. | journal=Lancet | year= 2011 | volume= 378 | issue= 9804 | pages= 1741-55 | pmid=21565397 | doi=10.1016/S0140-6736(11)60165-7 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21565397 }} </ref> | ||
* [[Ataxia]], [[dysarthria]], severe [[vertigo]] (suggestive of [[paraneoplastic cerebellar degeneration]]) may occur<ref name="pmid21565397">{{cite journal| author=van Meerbeeck JP, Fennell DA, De Ruysscher DK| title=Small-cell lung cancer. | journal=Lancet | year= 2011 | volume= 378 | issue= 9804 | pages= 1741-55 | pmid=21565397 | doi=10.1016/S0140-6736(11)60165-7 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21565397 }} </ref> | * [[Ataxia]], [[dysarthria]], severe [[vertigo]] (suggestive of [[paraneoplastic cerebellar degeneration]]) may occur<ref name="pmid21565397">{{cite journal| author=van Meerbeeck JP, Fennell DA, De Ruysscher DK| title=Small-cell lung cancer. | journal=Lancet | year= 2011 | volume= 378 | issue= 9804 | pages= 1741-55 | pmid=21565397 | doi=10.1016/S0140-6736(11)60165-7 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21565397 }} </ref> | ||
* Focal neurologic | *[[Focal neurologic signs]], [[seizures]], [[confusion]], and [[personality changes]] (suggestive of [[brain]] [[metastasis]]) | ||
===Extremities=== | |||
*[[Digital clubbing]] may be present | |||
* | *[[Bone]] [[tenderness]] (suggestive of [[bone]] [[metastasis]]) may be present | ||
* [[ | *[[Osteoarthropathy]] may be present: [[painful]] symmetrical [[arthropathy]] of the [[knees]], [[wrist]] and new periosteal [[bone]] formation | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
[[Category:Pulmonology]] | [[Category:Pulmonology]] | ||
[[Category:Lung cancer]] | [[Category:Lung cancer]] | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Pulmonology]] | |||
[[Category:Surgery]] | |||
Latest revision as of 22:19, 4 September 2019
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Small Cell Carcinoma of the Lung Microchapters |
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Differentiating Small Cell Carcinoma of the Lung from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-in-Chief: Guillermo Rodriguez Nava, M.D. [2]
Overview
Many authors have concluded that performing a complete assessment, with a detailed history and physical examination, is useful for identifying patients with a higher likelihood of metastases. Fever is reported in 20% of the patients. Patients may present with weight loss, cachexia and anorexia. Upon auscultation unilateral decreased air entry, unilateral wheeze, and decreased air entry in the bases of the lungs and/or crackles (suggestive of pleural effusion) may be present. The musculoskeletal system may show the signs of digital clubbing, bone tenderness, (suggestive of bone metastasis) and osteoarthropathy may be noted.
Physical Examination
The physical examination findings of small cell lung cancer are described below:[1][2][3]
Appearance of the Patient
- Cachexia (weight loss and anorexia) may be present
- Central obesity (suggestive of Cushing's syndrome) may be present
- Jaundice (suggestive of liver metastasis) may be present
- Pale skin (suggestive of anemia of chronic disease) may be present
- Cyanosis (suggestive of severe dyspnea) may be present
- Lymphadenopathy (> 1 cm) may be present
- Dehydration (suggestive of hypercalcemia) may be present
Vital Signs
- Fever (in up to 20% of the patients)
- Hypertension (can be present in case of Cushing's syndrome)
Skin
- Acquired tylosis may be present
- Tripe palms may be present[4]
- Erythema gyratum repens (rare)
HEENT
- Moon facies (suggestive of Cushing's syndrome) may be present
- Swelling of the face, neck, trunk, and arms (suggestive of superior vena cava syndrome) may be present
- Yellow discoloration of the sclera (suggestive of jaundice due to liver metastasis) may be present
- Conjunctival pallor (suggestive of anemia of chronic disease) may be present
- Miosis, ipsilateral ptosis and lack of facial sweating (suggestive of Horner's syndrome) may be present
- Hoarseness ( suggestive of compression of the recurrent laryngeal nerve) may be present
Neck
Lungs
- Unilateral decreased air entry may be present
- Unilateral wheeze may be present
- Decreased air entry in the bases of the lungs and/or crackles (suggestive of pleural effusion) may be present
Heart
- Cardiovascular examination of patients with small cell lung cancer is usually normal
Abdomen
- Hepatomegaly (> 13 cm span) (suggestive of liver metastasis) may be present
Back
Genitourinary
- Genitourinary examination of patients with small cell lung cancer is usually normal
Neuromuscular
- Weakness of the proximal muscles of lower extremities, abnormal gait, autonomic dysfunction, and paresthesia (suggestive of Lambert-Eaton syndrome) may be present[1]
- Altered mental status, seizures, memory loss, space and time disorientation, with or without dementia (suggestive of limbic encephalitis and encephalomyelitis) may occur[1]
- Ataxia, dysarthria, severe vertigo (suggestive of paraneoplastic cerebellar degeneration) may occur[1]
- Focal neurologic signs, seizures, confusion, and personality changes (suggestive of brain metastasis)
Extremities
- Digital clubbing may be present
- Bone tenderness (suggestive of bone metastasis) may be present
- Osteoarthropathy may be present: painful symmetrical arthropathy of the knees, wrist and new periosteal bone formation
References
- ↑ 1.0 1.1 1.2 1.3 van Meerbeeck JP, Fennell DA, De Ruysscher DK (2011). "Small-cell lung cancer". Lancet. 378 (9804): 1741–55. doi:10.1016/S0140-6736(11)60165-7. PMID 21565397.
- ↑ Sher T, Dy GK, Adjei AA (2008). "Small cell lung cancer". Mayo Clin Proc. 83 (3): 355–67. doi:10.4065/83.3.355. PMID 18316005.
- ↑ Spiro SG, Gould MK, Colice GL (September 2007). "Initial evaluation of the patient with lung cancer: symptoms, signs, laboratory tests, and paraneoplastic syndromes: ACCP evidenced-based clinical practice guidelines (2nd edition)". Chest. 132 (3 Suppl): 149S–160S. doi:10.1378/chest.07-1358. PMID 17873166.
- ↑ Mullans EA, Cohen PR (1996). "Tripe palms: a cutaneous paraneoplastic syndrome". South Med J. 89 (6): 626–7. PMID 8638207.