Liposarcoma differential diagnosis: Difference between revisions

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Revision as of 18:18, 21 September 2014

Differential diagnosis includes nonadipocytic lesions such as inflammatory myofibroblastic tumor and Castleman’s disease.^[1] Few are tabulated below.


Disease	Description

Spindle cell lipoma	Composed of bland, sometimes palisading, CD34-positive spindle cells, ad- mixed with eosinophilic refractile collagen bundles
Neurofibroma	Characterized by a less cellular S-100– positive spindle cell proliferation with wavy nuclei
Dermatofibrosarcoma protuberans	Cytologically bland, monomorphic CD34-positive spindle cell proliferation organized in a distinctive storiform growth pattern and characterized by tendency to infiltrate the surrounding fat in a peculiar ‘‘honeycomb’’ pattern
Malignant peripheral nerve sheath tumor	Generally highly cellular tumors composed of tapering or wavy spindle cells featuring perivascular accentuation and focal S-100– positive immunoreactivity in approximately 50% of cases ^[1]

References

↑ ^1.0 ^1.1 Dei Tos AP (2000). "Liposarcoma: new entities and evolving concepts". Ann Diagn Pathol. 4 (4): 252–66. doi:10.1053/adpa.2000.8133. PMID 10982304.

Template:WikiDoc Sources

[pmid10982304-1] 1.0 ^1.1 Dei Tos AP (2000). "Liposarcoma: new entities and evolving concepts". Ann Diagn Pathol. 4 (4): 252–66. doi:10.1053/adpa.2000.8133. PMID 10982304.

[1]

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 {{Liposarcoma}}
-Please help WikiDoc by adding more content here.  It's easy!  Click  [[Help:How_to_Edit_a_Page|here]]  to learn about editing.
-<!--
-Differential diagnosis includes nonadipo- cytic lesions such as inflammatory myofibroblastic tu- mor and Castleman’s disease.<ref name="pmid10982304">{{cite journal| author=Dei Tos AP| title=Liposarcoma: new entities and evolving concepts. | journal=Ann Diagn Pathol | year= 2000 | volume= 4 | issue= 4 | pages= 252-66 | pmid=10982304 | doi=10.1053/adpa.2000.8133 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10982304  }} </ref>
-Main differential diag- noses include spindle cell lipoma (composed of bland, sometimes palisading, CD34-positive spindle cells, ad- mixed with eosinophilic refractile collagen bundles), neurofibroma (characterized by a less cellular S-100– positive spindle cell proliferation with wavy nuclei), dermatofibrosarcoma protuberans (cytologically bland, monomorphic CD34-positive spindle cell proliferation organized in a distinctive storiform growth pattern and characterized by tendency to infiltrate the surrounding fat in a peculiar ‘‘honeycomb’’ pattern), malignant peripheral nerve sheath tumor (generally highly cellular tumors composed of tapering or wavy spindle cells featuring perivascular accentuation and focal S-100– positive immunoreactivity in approximately 50% of cases), and well-differentiated sclerosing liposarcoma (characterized by the presence of bizarre hyperchro- matic stromal cells set in fibrillary collagen). The pres- ence of an atypical lipomatous component also permits distinction from low-grade fibromyxoid sarcoma (Evans’ tumor). Interestingly, spindle cell liposarcoma exhibits chromosome changes (ring chromosomes and giant marker chromosomes) identical to those observed in other members of the well-differentiated liposarcoma group, thus validating its classification.<ref name="pmid10982304">{{cite journal| author=Dei Tos AP| title=Liposarcoma: new entities and evolving concepts. | journal=Ann Diagn Pathol | year= 2000 | volume= 4 | issue= 4 | pages= 252-66 | pmid=10982304 | doi=10.1053/adpa.2000.8133 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10982304  }} </ref>
+Differential diagnosis includes nonadipocytic lesions such as inflammatory myofibroblastic tumor and Castleman’s disease.<ref name="pmid10982304">{{cite journal| author=Dei Tos AP| title=Liposarcoma: new entities and evolving concepts. | journal=Ann Diagn Pathol | year= 2000 | volume= 4 | issue= 4 | pages= 252-66 | pmid=10982304 | doi=10.1053/adpa.2000.8133 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10982304  }} </ref>
+Few are tabulated below.
--->
+{| style="border: 0px; font-size: 90%; margin: 3px; width:600px" align=center
+|valign=top|
+|+
+! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Disease}}
+! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Description}}
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Spindle cell lipoma
+| style="padding: 5px 5px; background: #F5F5F5;" |Composed of bland, sometimes palisading, CD34-positive spindle cells, ad- mixed with eosinophilic refractile collagen bundles
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Neurofibroma
+| style="padding: 5px 5px; background: #F5F5F5;" |Characterized by a less cellular S-100– positive spindle cell proliferation with wavy nuclei
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Dermatofibrosarcoma protuberans
+ | style="padding: 5px 5px; background: #F5F5F5;" |Cytologically bland, monomorphic CD34-positive spindle cell proliferation organized in a distinctive storiform growth pattern and characterized by tendency to infiltrate the surrounding fat in a peculiar ‘‘honeycomb’’ pattern
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Malignant peripheral nerve sheath tumor
+| style="padding: 5px 5px; background: #F5F5F5;" | Generally highly cellular tumors composed of tapering or wavy spindle cells featuring perivascular accentuation and focal S-100– positive immunoreactivity in approximately 50% of cases
+<ref name="pmid10982304">{{cite journal| author=Dei Tos AP| title=Liposarcoma: new entities and evolving concepts. | journal=Ann Diagn Pathol | year= 2000 | volume= 4 | issue= 4 | pages= 252-66 | pmid=10982304 | doi=10.1053/adpa.2000.8133 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10982304  }} </ref>
+|}
 ==References==
@@ Line 17: / Line 34: @@
 [[Category:Disease]]
 [[Category:Types of cancer]]
-[[Category:Needs content]]
 [[Category:Oncology]]
 [[Category:Surgery]]

Liposarcoma differential diagnosis: Difference between revisions

Revision as of 18:18, 21 September 2014

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