Liposarcoma differential diagnosis: Difference between revisions
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==Overview== | ==Overview== | ||
Liposarcoma must be differentiated from other diseases that cause a painless, growing [[mass]] such as spindle cell [[lipoma]], [[neurofibroma]], [[dermatofibrosarcoma]] protuberans, and malignant peripheral nerve sheath tumor. | |||
==Differential diagnosis== | ==Differential diagnosis== | ||
Differential diagnosis includes nonadipocytic lesions such as inflammatory myofibroblastic tumor and Castleman’s disease.<ref name="pmid10982304">{{cite journal| author=Dei Tos AP| title=Liposarcoma: new entities and evolving concepts. | journal=Ann Diagn Pathol | year= 2000 | volume= 4 | issue= 4 | pages= 252-66 | pmid=10982304 | doi=10.1053/adpa.2000.8133 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10982304 }} </ref> | Differential diagnosis includes nonadipocytic lesions such as inflammatory myofibroblastic tumor and Castleman’s disease.<ref name="pmid10982304">{{cite journal| author=Dei Tos AP| title=Liposarcoma: new entities and evolving concepts. | journal=Ann Diagn Pathol | year= 2000 | volume= 4 | issue= 4 | pages= 252-66 | pmid=10982304 | doi=10.1053/adpa.2000.8133 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10982304 }} </ref> | ||
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! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Description}} | ! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Description}} | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Spindle cell lipoma | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Spindle cell [[lipoma]] | ||
| style="padding: 5px 5px; background: #F5F5F5;" |Composed of bland, sometimes palisading, CD34-positive spindle cells, ad- mixed with eosinophilic refractile collagen bundles | | style="padding: 5px 5px; background: #F5F5F5;" |Composed of bland, sometimes palisading, CD34-positive spindle cells, ad- mixed with eosinophilic refractile collagen bundles | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Neurofibroma | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |[[Neurofibroma]] | ||
| style="padding: 5px 5px; background: #F5F5F5;" |Characterized by a less cellular S-100– positive spindle cell proliferation with wavy nuclei | | style="padding: 5px 5px; background: #F5F5F5;" |Characterized by a less cellular S-100– positive spindle cell proliferation with wavy nuclei | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Malignant peripheral nerve sheath tumor | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Malignant peripheral nerve sheath tumor | ||
| style="padding: 5px 5px; background: #F5F5F5;" | Generally highly cellular tumors composed of tapering or wavy spindle cells featuring perivascular accentuation and focal S-100– positive immunoreactivity in approximately 50% of cases | | style="padding: 5px 5px; background: #F5F5F5;" | Generally highly cellular tumors composed of tapering or wavy spindle cells featuring perivascular accentuation and focal S-100– positive immunoreactivity in approximately 50% of cases<ref name="pmid10982304">{{cite journal| author=Dei Tos AP| title=Liposarcoma: new entities and evolving concepts. | journal=Ann Diagn Pathol | year= 2000 | volume= 4 | issue= 4 | pages= 252-66 | pmid=10982304 | doi=10.1053/adpa.2000.8133 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10982304 }} </ref> | ||
<ref name="pmid10982304">{{cite journal| author=Dei Tos AP| title=Liposarcoma: new entities and evolving concepts. | journal=Ann Diagn Pathol | year= 2000 | volume= 4 | issue= 4 | pages= 252-66 | pmid=10982304 | doi=10.1053/adpa.2000.8133 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10982304 }} </ref> | |||
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[[Category:Oncology]] | [[Category:Oncology]] | ||
[[Category:Surgery]] | [[Category:Surgery]] | ||
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Revision as of 20:58, 22 September 2014
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Liposarcoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Liposarcoma differential diagnosis On the Web |
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American Roentgen Ray Society Images of Liposarcoma differential diagnosis |
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Risk calculators and risk factors for Liposarcoma differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Liposarcoma must be differentiated from other diseases that cause a painless, growing mass such as spindle cell lipoma, neurofibroma, dermatofibrosarcoma protuberans, and malignant peripheral nerve sheath tumor.
Differential diagnosis
Differential diagnosis includes nonadipocytic lesions such as inflammatory myofibroblastic tumor and Castleman’s disease.[1] Few are tabulated below.
| Disease | Description |
|---|---|
| Spindle cell lipoma | Composed of bland, sometimes palisading, CD34-positive spindle cells, ad- mixed with eosinophilic refractile collagen bundles |
| Neurofibroma | Characterized by a less cellular S-100– positive spindle cell proliferation with wavy nuclei |
| Dermatofibrosarcoma protuberans | Cytologically bland, monomorphic CD34-positive spindle cell proliferation organized in a distinctive storiform growth pattern and characterized by tendency to infiltrate the surrounding fat in a peculiar ‘‘honeycomb’’ pattern |
| Malignant peripheral nerve sheath tumor | Generally highly cellular tumors composed of tapering or wavy spindle cells featuring perivascular accentuation and focal S-100– positive immunoreactivity in approximately 50% of cases[1] |
References
- ↑ 1.0 1.1 Dei Tos AP (2000). "Liposarcoma: new entities and evolving concepts". Ann Diagn Pathol. 4 (4): 252–66. doi:10.1053/adpa.2000.8133. PMID 10982304.