Liposarcoma natural history: Difference between revisions
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==Complications== | ==Complications== | ||
*Liposarcoma may cause metastasis to other organs and the lung is the most common location for metastatic disease. | *Liposarcoma may cause metastasis to other organs and the lung is the most common location for metastatic disease. | ||
*A myxoid liposarcoma metastasize more commonly to extrapulmonary locations, such as retroperitoneum, pericardium, chest wall, pleura, pelvic soft tissue.<ref name="PetersonKransdorf2003">{{cite journal|last1=Peterson|first1=Jeffrey J.|last2=Kransdorf|first2=Mark J.|last3=Bancroft|first3=Laura W.|last4=O'Connor|first4=Mary I.|title=Malignant fatty tumors: classification, clinical course, imaging appearance and treatment|journal=Skeletal Radiology|volume=32|issue=9|year=2003|pages=493–503|issn=0364-2348|doi=10.1007/s00256-003-0647-8}}</ref> | |||
*Retroperitoneal liposarcomas may affect adjacent organs and structures, that could lead to kidney disease or vascular compression. <ref>{{Cite journal | |||
| author = [[Amit Gupta]], [[Omar Pacha]], [[Rony Skaria]], [[Tam Huynh]], [[Luan Truong]] & [[Abdul Abdellatif]] | |||
| title = Retroperitoneal sarcoma presenting as acute renal failure, secondary to bilateral renal artery invasion | |||
| journal = [[Clinical nephrology]] | |||
| volume = 78 | |||
| issue = 2 | |||
| pages = 164–168 | |||
| year = 2012 | |||
| month = August | |||
| pmid = 22790462 | |||
}}</ref> | |||
==Prognosis== | ==Prognosis== | ||
Revision as of 15:03, 22 September 2014
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Liposarcoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Liposarcoma natural history On the Web |
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American Roentgen Ray Society Images of Liposarcoma natural history |
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Risk calculators and risk factors for Liposarcoma natural history |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]
Overview
Natural History
- The natural history of liposarcoma would depend on the histopathological subtype and location.
- Liposarcomas may remain asymptomatic for a long time, specially if they are located in the retroperitoneum.
- Retroperitoneal liposarcomas may remain asymtomatic for many years (5-10 years), compared to liposarcomas in the extremities. [1]
- The common presentation for a liposarcoma located in the extremities is a painless growing mass without additional symptoms.
- The lower extremities are the most common location of liposarcomas. [1]
- Between 10 and 15% of patients may present with pain in the affected region. [1]
- Retroperitoneal liposarcomas may present as a dull abdominal pain, weight loss and abdominal distention.[2]
Complications
- Liposarcoma may cause metastasis to other organs and the lung is the most common location for metastatic disease.
- A myxoid liposarcoma metastasize more commonly to extrapulmonary locations, such as retroperitoneum, pericardium, chest wall, pleura, pelvic soft tissue.[1]
- Retroperitoneal liposarcomas may affect adjacent organs and structures, that could lead to kidney disease or vascular compression. [3]
Prognosis
- The prognosis of liposarcoma will depend on the histopathological subtype.
- Atypical lipomatous neoplasm/well-differentiated liposarcoma has a low metastasis risk, but may recur locally. The prognosis for this subtype is better than for other subtypes of liposarcoma.[1]
- The pleomorphic liposarcoma has a high metastasis potential and a high recurrence. The 5-year disease free survival rate for pleomorphic liposarcoma is 40%.[4]
- The 5-year disease free survival rate for liposarcoma located in the extremities is 74%.[5]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Peterson, Jeffrey J.; Kransdorf, Mark J.; Bancroft, Laura W.; O'Connor, Mary I. (2003). "Malignant fatty tumors: classification, clinical course, imaging appearance and treatment". Skeletal Radiology. 32 (9): 493–503. doi:10.1007/s00256-003-0647-8. ISSN 0364-2348.
- ↑ E. Y. Ki, S. T. Park, J. S. Park & S. Y. Hur (2012). "A huge retroperitoneal liposarcoma: case report". European journal of gynaecological oncology. 33 (3): 318–320. PMID 22873110.
- ↑ Amit Gupta, Omar Pacha, Rony Skaria, Tam Huynh, Luan Truong & Abdul Abdellatif (2012). "Retroperitoneal sarcoma presenting as acute renal failure, secondary to bilateral renal artery invasion". Clinical nephrology. 78 (2): 164–168. PMID 22790462. Unknown parameter
|month=ignored (help) - ↑ A. M. Oliveira & A. G. Nascimento (2001). "Pleomorphic liposarcoma". Seminars in diagnostic pathology. 18 (4): 274–285. PMID 11757868. Unknown parameter
|month=ignored (help) - ↑ D. B. Pearlstone, P. W. Pisters, R. J. Bold, B. W. Feig, K. K. Hunt, A. W. Yasko, S. Patel, A. Pollack, R. S. Benjamin & R. E. Pollock (1999). "Patterns of recurrence in extremity liposarcoma: implications for staging and follow-up". Cancer. 85 (1): 85–92. PMID 9921978. Unknown parameter
|month=ignored (help)