Liposarcoma laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]

Laboratory Findings

Biopsy

Although imaging assists in the diagnosis of liposarcoma, a biopsy is needed to confirm the disease and determine the histopathological subtype of liposarcoma.

Subtype	Findings
Atypical Lipomatous Neoplasm (ALN)/Well-Differentiated Liposarcoma (WDL)	Multivacuolated adipose cells and spindle cells with a hyperchromatic nuclei. Fibrotic areas and atypical stroma cells.
Dedifferentiated Liposarcoma	Transition from a low-grade to a high-grade differentiation within the same mass of well-differentiated liposarcoma.
Myxoid Liposarcoma	Multinodular mass with round cells, hyaluronic acid matrix. High cellularity at the periphery and low cellularity inside the mass.
Pleomorphic Liposarcoma	Lipoblasts with increased size, hyperchromatic nuclei, acidophilic cytoplasm and eosinophilic hyaline globules.
Table adapted from Enzinger and Weiss's Soft Tissue Tumors , 6th Edition

Well Differentiated Liposarcoma. Image courtesy of Wikimedia Commons.	Dedifferentiated Liposarcoma. Image courtesy of Wikimedia Commons.	Dedifferentiated Liposarcoma. Image courtesy of Wikimedia Commons.
Dedifferentiated Liposarcoma. Image courtesy of Wikimedia Commons.	Dedifferentiated Liposarcoma. Image courtesy of Wikimedia Commons.