Liposarcoma laboratory findings

Liposarcoma Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Liposarcoma from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X-ray
Echocardiography and Ultrasound
CT scan
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Liposarcoma laboratory findings On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Liposarcoma laboratory findings All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Liposarcoma laboratory findings
CDC on Liposarcoma laboratory findings
Liposarcoma laboratory findings in the news
Blogs on Liposarcoma laboratory findings
Directions to Hospitals Treating Liposarcoma
Risk calculators and risk factors for Liposarcoma laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]

Overview

A biopsy of the liposarcoma will give the definitive diagnosis and the histopathological subtype of liposarcoma. Other laboratory finding include anemia, due to GI bleeding, and increased BUN and creatinine in case of obstructive nephropathy.

Laboratory Findings

Biopsy

Although imaging assists in the diagnosis of liposarcoma, a biopsy is needed to confirm the disease and determine the histopathological subtype of liposarcoma.

Subtype	Findings
Atypical Lipomatous Neoplasm (ALN)/Well-Differentiated Liposarcoma (WDL)	4 subtypes: lipoma-like, sclerosing, spindle cell and inflammatory. Multivacuolated lipoblasts and spindle cells with a hyperchromatic nuclei. Fibrotic areas and atypical stroma cells may be observed.
Dedifferentiated Liposarcoma	Abrupt transition from a low-grade to a high-grade differentiation within the same mass of well-differentiated liposarcoma.
Myxoid Liposarcoma	Multinodular mass with round cells, hyaluronic acid matrix. High cellularity at the periphery and low cellularity inside the mass. Mitotic activity is normal and the nuclei is normochromatic.
Pleomorphic Liposarcoma	Pleomorphic lipoblasts with hyperchromatic nuclei, acidophilic cytoplasm and eosinophilic hyaline globules; spinde cells and multinucleated giant cells may be observed.
Mixed-type Liposarcoma	Mixed features of myxoid, pleomorphic and well-differentiated liposarcoma.
Table adapted from Fletcher C.D.M., Unni K.K., Mertens F. (Eds.): WHO Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone and Enzinger and Weiss's Soft Tissue Tumors , 6th Edition

Well Differentiated Liposarcoma. Image courtesy of Wikimedia Commons.	Dedifferentiated Liposarcoma. Image courtesy of Wikimedia Commons.	Dedifferentiated Liposarcoma. Image courtesy of Wikimedia Commons.
Dedifferentiated Liposarcoma. Image courtesy of Wikimedia Commons.	Dedifferentiated Liposarcoma. Image courtesy of Wikimedia Commons.

Laboratory Tests

• There are no specific laboratory test findings for the diagnosis of liposarcoma.
• In cases of ureter or kidney involvement, an elevated creatinine and BUN may be seen.
• Anemia may be present, specially if there is bleeding associated with the liposarcoma.
• The level of D-dimer has been studied as a marker for the differential diagnosis of lipoma and well-differentiated liposarcoma, the latter having higher levels of D-dimer.