Liposarcoma laboratory findings: Difference between revisions
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The definitive diagnosis of liposarcoma is made by biopsy, which also provides histopathological classification of the liposarcoma's subtype. Other pertinent laboratory finding include anemia and elevated BUN due to GI bleeding and elevated creatinine among patients with obstructive nephropathy. | The definitive diagnosis of liposarcoma is made by biopsy, which also provides histopathological classification of the liposarcoma's subtype. Other pertinent laboratory finding include anemia and elevated BUN due to GI bleeding and elevated creatinine among patients with obstructive nephropathy. | ||
==Laboratory | ==Laboratory findings== | ||
===Biopsy=== | ===Biopsy=== | ||
Although imaging may be helpful in the diagnosis of liposarcoma, the optimal method for diagnosis of liposarcoma is by biopsy. A biopsy also provides important histopathological information requires to identify the subtype of the liposarcoma. | Although imaging may be helpful in the diagnosis of liposarcoma, the optimal method for diagnosis of liposarcoma is by biopsy. A biopsy also provides important histopathological information requires to identify the subtype of the liposarcoma. | ||
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===Laboratory | ===Laboratory tests=== | ||
*There are no specific laboratory tests for the diagnosis of liposarcoma. | *There are no specific laboratory tests for the diagnosis of liposarcoma. | ||
*Patients with[[ureteral]] or [[renal]] involvement, an elevated [[creatinine]] may be observed. | *Patients with[[ureteral]] or [[renal]] involvement, an elevated [[creatinine]] may be observed. | ||
Revision as of 19:55, 23 September 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]
Overview
The definitive diagnosis of liposarcoma is made by biopsy, which also provides histopathological classification of the liposarcoma's subtype. Other pertinent laboratory finding include anemia and elevated BUN due to GI bleeding and elevated creatinine among patients with obstructive nephropathy.
Laboratory findings
Biopsy
Although imaging may be helpful in the diagnosis of liposarcoma, the optimal method for diagnosis of liposarcoma is by biopsy. A biopsy also provides important histopathological information requires to identify the subtype of the liposarcoma.
| Subtype | Findings |
|---|---|
| Atypical Lipomatous Neoplasm (ALN)/Well-Differentiated Liposarcoma (WDL) | 4 subtypes:
Multivacuolated lipoblasts and spindle cells with hyperchromatic nuclei are often observed. |
| De-differentiated Liposarcoma | Abrupt transition from a low-grade to a high-grade differentiation within the same mass of a well-differentiated liposarcoma. |
| Myxoid liposarcoma | Multinodular mass with round cells and hyaluronic acid matrix. High cellularity at the periphery and low cellularity at the center of the mass. Mitotic activity is normal and the nuclei are normochromatic. |
| Pleomorphic liposarcoma | Pleomorphic lipoblasts with hyperchromatic nuclei, acidophilic cytoplasm, and eosinophilic hyaline globules. Spindle cells and multinucleated giant cells may be observed. |
| Mixed-type Liposarcoma | Mixed features of myxoid, pleomorphic, and well-differentiated liposarcoma. |
| Table adapted from Fletcher CDM, Unni KK, Mertens F, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Geneva:IARC Press; 2002[1] and Enzinger and Weiss's Soft Tissue Tumors , 6th Edition [2] | |
 Retrieved from Wikimedia Commons. Original image courtesy of Panoraia Paraskeva, Paraskevas Katsaronis, Eleftherios D Spartalis, et al. Giant liposarcoma of the back with 4 types of histopathology: a case report. Cases Journal. 2009; 2:9339(Open Access) |
 Retrieved from Wikimedia Commons. Image by user: Nephron, licensed under GNU Free Documentation License |
 Retrieved from Wikimedia Commons. Image by user: Nephron, licensed under GNU Free Documentation License |
 Retrieved from Wikimedia Commons. Image by user: Nephron, licensed under GNU Free Documentation License |
 Retrieved from Wikimedia Commons. Image by user: Nephron, licensed under GNU Free Documentation License |
Laboratory tests
- There are no specific laboratory tests for the diagnosis of liposarcoma.
- Patients withureteral or renal involvement, an elevated creatinine may be observed.
- Anemia and elevated BUN may be present among patients with liposarcoma assoicated with GI bleeding.[3]
- The level of D-dimer has been studied as a marker for the differential diagnosis of lipoma and well-differentiated liposarcoma. Results have demonstrated that liposarcoma may have increased levels of D-dimer compared to lipoma.[4]
References
- ↑ Fletcher, Christopher (2002). Pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press. ISBN 9283224132.
- ↑ Goldblum, John (2014). Enzinger and Weiss's soft tissue tumors. Philadelphia, PA: Saunders/Elsevier. ISBN 978-0-323-08834-3.
- ↑ Nennstiel, Simon; Mollenhauer, Martin; Schlag, Christoph; Becker, Valentin; Neu, Bruno; Hüser, Norbert; Gertler, Ralf; Schmid, Roland M.; von Delius, Stefan (2014). "Small Bowel Pleomorphic Liposarcoma: A Rare Cause of Gastrointestinal Bleeding". Case Reports in Gastrointestinal Medicine. 2014: 1–4. doi:10.1155/2014/391871. ISSN 2090-6528.
- ↑ Akira Yoshiyama, Takeshi Morii, Takashi Tajima, Takayuki Aoyagi, Keita Honya, Kazuo Mochizuki, Kazuhiko Satomi & Shoichi Ichimura (2014). "D-dimer Levels in the Differential Diagnosis Between Lipoma and Well-differentiated Liposarcoma". Anticancer research. 34 (9): 5181–5185. PMID 25202112. Unknown parameter
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