Fever of unknown origin laboratory findings: Difference between revisions
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* [[Basic metabolic panel]] | * [[Basic metabolic panel]] | ||
* [[Liver function test]] including [[AST]], [[ALT]], [[LDH]], [[bilirubin]], and [[alkaline phosphatase]] | * [[Liver function test]] including [[AST]], [[ALT]], [[LDH]], [[bilirubin]], and [[alkaline phosphatase]] | ||
* Creatine kinase | * [[Creatine kinase]] | ||
* Blood cultures (at least 2 sets) | * [[Blood cultures]] (at least 2 sets) | ||
* Urinalysis with microscopic examination | * [[Urinalysis]] with microscopic examination | ||
* Urine | * [[Urine culture]]s | ||
* Erythrocyte sedimentation rate | * [[Erythrocyte sedimentation rate]] | ||
* C-reactive protein | * [[C-reactive protein]] | ||
* Gamma-glutamyl transferase | * [[Gamma-glutamyl transferase]] | ||
* Coombs test | * [[Coombs test]] | ||
* Cold agglutinins | * [[Cold agglutinins]] | ||
* Ferritin | * [[Ferritin]] | ||
* Angiotensin-converting enzyme | * [[Angiotensin-converting enzyme]] | ||
* Thyroid peroxidase and anti-thyroglobulin antibodies | * [[Thyroid peroxidase]] and [[ATG|anti-thyroglobulin antibodies]] | ||
* Antinuclear antibodies | * [[Antinuclear antibodies]] | ||
* Rheumatoid factor | * [[Rheumatoid factor]] | ||
* Cryoglobulins | * [[Cryoglobulins]] | ||
* | * [[Cytomegalovirus]] [[serology]] and [[heterophile antibody test]] if positive for atypical lymphocytes | ||
* Q fever antibodies for patients with exposure to livestocks | * Q fever antibodies for patients with exposure to livestocks | ||
* HIV antibody | * HIV antibody | ||
Revision as of 18:57, 3 April 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: febris continua e causa ignota; febris e causa ignota; febris E.C.I.; fever/pyrexia of obscured/undetermined/uncertain/unidentifiable/unknown focus/origin/source; fever/pyrexia without a focus/origin/source; FUO; PUO
Overview
A comprehensive and meticulous history (i.e. illness of family members, recent visit to the tropics, medication), repeated physical examination (i.e. skin rash, eschar, lymphadenopathy, heart murmur) and a myriad of laboratory tests (serological, blood culture, immunological) are the cornerstone of finding the cause.
Laboratory Findings
Initial laboratory studies in patients with FUO
- Complete blood count with differential
- Basic metabolic panel
- Liver function test including AST, ALT, LDH, bilirubin, and alkaline phosphatase
- Creatine kinase
- Blood cultures (at least 2 sets)
- Urinalysis with microscopic examination
- Urine cultures
- Erythrocyte sedimentation rate
- C-reactive protein
- Gamma-glutamyl transferase
- Coombs test
- Cold agglutinins
- Ferritin
- Angiotensin-converting enzyme
- Thyroid peroxidase and anti-thyroglobulin antibodies
- Antinuclear antibodies
- Rheumatoid factor
- Cryoglobulins
- Cytomegalovirus serology and heterophile antibody test if positive for atypical lymphocytes
- Q fever antibodies for patients with exposure to livestocks
- HIV antibody
- Serum protein electrophoresis
- Tuberculin skin test
- Fecal occult blood test