Aplastic anemia laboratory findings: Difference between revisions
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===Reticulocyte Count=== | ===Reticulocyte Count=== | ||
* Low reticulocyte levels. | * Low [[reticulocyte]] levels. | ||
===Other tests=== | ===Other tests=== |
Revision as of 17:19, 19 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2]
Overview
Patients with aplastic anemia have a hypoplastic bone marrow (<20% cellularity), pancytopenia (transfusion-dependent anemia, thrombocytopenia, and severe neutropenia), a low reticulocyte count, and with normal maturation of all cell lines.
Laboratory Findings
Complete Blood Count (CBC)
- Decreased hemoglobin
- Decreased hematocrit
- Pancytopenia (anemia, thrombocytopenia, and severe neutropenia)
- Mean corpuscular volume
Reticulocyte Count
- Low reticulocyte levels.
Other tests
- Renal function
- Basic metabolic panel
- Liver enzymes
- Thyroid function tests
- Viral studies
- vitamin B12 and folic acid levels.
Definitive Diagnosis
Bone Marrow Aspiration and Biopsy
- Bone marrow aspiration might be done to find out if and why bone marrow isn't making enough blood cells. For this test, a small amount of bone marrow fluid is aspirated through a needle. The sample is looked at under a microscope to check for faulty cells.
- A bone marrow biopsy might be done at the same time as an aspiration or afterward. For this test, your doctor removes a small amount of bone marrow tissue through a needle. The tissue is checked for the number and types of cells in the bone marrow. In aplastic anemia, the bone marrow has a lower than normal number of all three types of blood cells.
- Bone marrow biopsy (hypoplastic bone marrow (<20% cellularity), and with normal maturation of all cell lines.