Aplastic anemia (patient information)

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Overview

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What are the symptoms of aplastic anemia?

• Symptoms are due to the underproduction of red cells, white cells, and platelets. Symptoms may be severe from the start or gradually worsen over time as the disease progresses.
• Low red cell count (anemia) can cause:

• Fatigue
• Pallor (paleness)
• Rapid heart rate
• Shortness of breath with exercise
• Weakness
• Lightheadedness upon standing

• Low white cell count (leukopenia) causes an increased risk of infection.
• Low platelet count (thrombocytopenia) can result in bleeding. Symptoms include:

• Bleeding gums
• Easy bruising
• Frequent or severe infections
• Nose bleeds
• Rash, small pinpoint red marks on the skin (petechiae)

What causes aplastic anemia?

• Use of certain drugs or exposure to toxic chemicals (such as benzene.
• Exposure to radiation and/or chemotherapy
• Autoimmune disorders
• Pregnancy
• Viruses

Who is at highest risk?

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Diagnosis

• Blood tests will show:

• Low red blood cell count (anemia)
• Low white blood cell count (leukopenia)
• Low reticulocyte count (reticulocytes are immature red blood cell)
• Low platelet count (thrombocytopenia)

• A bone marrow biopsy shows fewer-than-normal blood cells and an increased amount of fat.

When to seek urgent medical care?

• Call your health care provider or go to the emergency room if bleeding occurs for no reason, or if bleeding is hard to stop. Call if you notice frequent infections or unusual fatigue.

Treatment options

• Mild cases of aplastic anemia that do not have symptoms may not require treatment.
• As blood counts become lower and symptoms develop, blood and platelets are given through transfusions. Over time, transfusions may stop working, resulting in very low blood cell counts. This is a life-threatening condition.
• Bone marrow or stem cell transplant may be recommended for people under age 40. This treatment works best when the donor is a fully-matched brother or sister. This is called a matched sibling donor.
• Older people and those who do not have a matched sibling donor are given medicine to suppress the immune system. These medicines may allow the bone marrow to once again make healthy blood cells. But the disease may return (relapse). A bone marrow transplant with an unrelated donor may be tried if these medicines do not help or if the disease comes back after getting better.

Where to find medical care for aplastic anemia?

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Prevention

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What to expect (Outlook/Prognosis)?

• Untreated, severe aplastic anemia leads to rapid death. Bone marrow transplant can be very successful in young people. Transplant is also used in older people or when the disease comes back after medicines have stopped working.

Possible complications

• Complications may include:

• Severe infections or bleeding
• Complications of bone marrow transplant
• Reactions to medicines
• Hemochromatosis (buildup of too much iron in the body tissues from many red cell transfusions)

Sources

• The National Library of Medicine http://www.nlm.nih.gov/medlineplus/.