Endometrial hyperplasia classification: Difference between revisions

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Revision as of 14:56, 3 March 2016

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Overview

Classification

Endometrial hyperplasia may be classified according into the following types:

References

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Endometrial hyperplasia

Simple

Complex

Simple hyperplasia with atypia

Simple hyperplasia without atypia

Complex hyperplasia with atypia

Complex hyperplasia without atypia

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Endometrial hyperplasia}}
-{{CMG}}
+{{CMG}}{{AE}} {{STM}}
+==Overview==
-==Overview==
 ==Classification==
-Like other [[hyperplasia|hyperplastic]] disorders, endometrial hyperplasia initially represents a [[physiology|physiological]] response of endometrial tissue to the growth-promoting actions of [[estrogen]]. However, the gland-forming cells of a hyperplastic endometrium may also undergo changes over time which predispose them to [[cancer]]ous transformation. Several [[microscopic|histopathology]] subtypes of endometrial hyperplasia are recognisable to the [[pathology|pathologist]], with different therapeutic and [[prognosis|prognostic]] implications.<ref name="Weidner's">{{cite book |author=Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) |title=Modern Surgical Pathology (2 Volume Set) |publisher=W B Saunders |location=London |year= |pages= |isbn=0-7216-7253-1 |oclc= |doi=}}</ref>
+Endometrial hyperplasia may be classified according into the following types:
-*Endometrial hyperplasia (simple or complex) - Irregularity and cystic expansion of glands (simple) or crowding and budding of glands (complex) without worrisome changes in the appearance of individual gland cells. In one study, 1.6% of patients diagnosed with these abnormalities eventually developed endometrial cancer.<ref name="Kurman">{{cite journal |author=Kurman RJ, Kaminski PF, Norris HJ |title=The behavior of endometrial hyperplasia. A long-term study of "untreated" hyperplasia in 170 patients |journal=Cancer |volume=56 |issue=2 |pages=403-12 |year=1985 |pmid=4005805 |doi=}}</ref>
+{{familytree/start |summary=Endometrial hyperplasia classification}}
+{{familytree |boxstyle=background: #DCDCDC; | | | | | | | | | | A01 |A01=<div style="width: 12em; padding:0.2em;">'''Endometrial hyperplasia'''</div>}}
-*Atypical endometrial hyperplasia (simple or complex) - Simple or complex architectural changes, with worrisome (''atypical'') changes in gland cells, including cell stratification, tufting, loss of nuclear polarity, enlarged nuclei, and an increase in [[mitosis|mitotic activity]]. These changes are similar to those seen in true cancer cells, but atypical hyperplasia does not show invasion into the connective tissues, the defining characteristic of cancer. The previously mentioned study found that 22% of patients with atypical hyperplasia eventually developed cancer.<ref name="Kurman">{{cite journal |author=Kurman RJ, Kaminski PF, Norris HJ |title=The behavior of endometrial hyperplasia. A long-term study of "untreated" hyperplasia in 170 patients |journal=Cancer |volume=56 |issue=2 |pages=403-12 |year=1985 |pmid=4005805 |doi=}}</ref>
+{{familytree |boxstyle=background: #DCDCDC; | | | | | | |,|-|-|-|^|-|-|-|.| }}
+{{familytree |boxstyle=background: #DCDCDC; | | | | | | B01 | | | | | | B02 |B01=<div style="width: 9em; padding:0.2em;">'''Simple'''
+</div>|B02=<div style="width: 9em; padding:0.2em;">'''Complex'''</div>}}
+{{familytree |boxstyle=background: #DCDCDC; | | | | |,|-|^|-|.| | | |,|-|^|-|.|}}
+{{familytree |boxstyle=background: #DCDCDC; | | | | C01 | | C02 | | C03 | | C04|C01=<div style="width: 9em; padding:0.2em;">'''Simple hyperplasia with atypia '''
+</div>|C02=<div style="width: 9em; padding:0.2em;">'''Simple hyperplasia without atypia'''</div>|C03=<div style="width: 9em; padding:0.2em;">'''Complex hyperplasia with atypia '''
+</div>|C04=<div style="width: 9em; padding:0.2em;">'''Complex hyperplasia without atypia '''
+</div>|}}
 ==References==
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 [[Category:Types of cancer]]
 [[Category:Gynecology]]
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Endometrial hyperplasia classification: Difference between revisions

Revision as of 14:56, 3 March 2016

Overview

Classification

References

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