Liposarcoma natural history: Difference between revisions
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==Overview== | ==Overview== | ||
[[Metastasis]] is the most important aspect to assess in the [[prognosis]] of liposarcoma, but the mass may compress adjacent structures causing different clinical manifestations. The prognosis will depend on the [[histopathological]] subtype, being the well differentiated liposarcoma the subtype with the best [[prognosis]], and the pleomorphic liposarcoma with the worst [[prognosis]]. | |||
==Natural History== | ==Natural History== | ||
Revision as of 20:02, 25 August 2015
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Liposarcoma Microchapters |
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Liposarcoma natural history On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]
Overview
Metastasis is the most important aspect to assess in the prognosis of liposarcoma, but the mass may compress adjacent structures causing different clinical manifestations. The prognosis will depend on the histopathological subtype, being the well differentiated liposarcoma the subtype with the best prognosis, and the pleomorphic liposarcoma with the worst prognosis.
Natural History
- The natural history of liposarcoma would depend on the histopathological subtype and location.
- If left untreated, liposarcomas may remain silent for a long time, specially if they are located in the retroperitoneum.
- Retroperitoneal liposarcomas may remain silent for many years (5-10 years), compared to liposarcomas in the extremities.[1]
- The common presentation for a liposarcoma located in the extremities is a painless growing mass without additional symptoms.
Complications
- Liposarcoma may cause metastasis to other organs.
- Lung is the most common location for metastatic disease.
- A myxoid liposarcoma metastasize more commonly to extrapulmonary locations, such as retroperitoneum, pericardium, chest wall, pleura, pelvic soft tissue.[1]
- Retroperitoneal liposarcomas may affect adjacent organs and structures, that could lead to kidney disease or vascular compression.[2]
- A case of pancreatitis has been reported due to a dedifferentiated retroperitoneal liposarcoma.[3]
Prognosis
- The prognosis of liposarcoma will depend on the histopathological subtype.
- Atypical lipomatous neoplasm/well-differentiated liposarcoma has a low metastasis risk, but may recur locally. The prognosis for this subtype is better than for other subtypes of liposarcoma.[1]
- The pleomorphic liposarcoma has a high metastasis potential and a high recurrence. The 5-year disease free survival rate for pleomorphic liposarcoma is 40%.[4]
- The 5-year disease free survival rate for liposarcoma located in the extremities is 74%.[5]
References
- ↑ 1.0 1.1 1.2 Peterson, Jeffrey J.; Kransdorf, Mark J.; Bancroft, Laura W.; O'Connor, Mary I. (2003). "Malignant fatty tumors: classification, clinical course, imaging appearance and treatment". Skeletal Radiology. 32 (9): 493–503. doi:10.1007/s00256-003-0647-8. ISSN 0364-2348.
- ↑ Amit Gupta, Omar Pacha, Rony Skaria, Tam Huynh, Luan Truong & Abdul Abdellatif (2012). "Retroperitoneal sarcoma presenting as acute renal failure, secondary to bilateral renal artery invasion". Clinical nephrology. 78 (2): 164–168. PMID 22790462. Unknown parameter
|month=ignored (help) - ↑ Yusuke Arakawa, Kazuo Yoshioka, Hitomi Kamo, Koichiro Kawano, Takeshi Yamaguchi, Yuko Sumise, Natsu Okitsu, Shizuo Ikeyama, Kojiro Morimoto, Yoshihiro Nakai & Seiki Tashiro (2013). "Huge retroperitoneal dedifferentiated liposarcoma presented as acute pancreatitis: report of a case". The journal of medical investigation : JMI. 60 (1–2): 164–168. PMID 23614927.
- ↑ A. M. Oliveira & A. G. Nascimento (2001). "Pleomorphic liposarcoma". Seminars in diagnostic pathology. 18 (4): 274–285. PMID 11757868. Unknown parameter
|month=ignored (help) - ↑ D. B. Pearlstone, P. W. Pisters, R. J. Bold, B. W. Feig, K. K. Hunt, A. W. Yasko, S. Patel, A. Pollack, R. S. Benjamin & R. E. Pollock (1999). "Patterns of recurrence in extremity liposarcoma: implications for staging and follow-up". Cancer. 85 (1): 85–92. PMID 9921978. Unknown parameter
|month=ignored (help)