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| ==Overview== | | ==Overview== |
| The definitive diagnosis of liposarcoma is made by biopsy, which also provides histopathological classification of the liposarcoma's subtype. Other pertinent laboratory findings include anemia and elevated BUN due to GI bleeding and elevated creatinine among patients with obstructive nephropathy. | | The pertinent laboratory findings of liposarcoma include [[anemia]] and [[BUN|elevated BUN]] due to GI bleeding and elevated [[creatinine]] among patients with [[obstructive nephropathy]]. |
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| ==Laboratory findings== | | ==Laboratory findings== |
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| | pmid = 25202112 | | | pmid = 25202112 |
| }}</ref> | | }}</ref> |
| ===Biopsy===
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| Although imaging may be helpful in the diagnosis of liposarcoma, the optimal method for diagnosis of liposarcoma is by biopsy. A biopsy also provides important histopathological information requires to identify the subtype of the liposarcoma.
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| {| style="border: 0px; font-size: 90%; margin: 3px; width: 700px" align=center
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| ! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Subtype}}
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| ! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Findings}}
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| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Atypical Lipomatous Neoplasm (ALN)/Well-Differentiated Liposarcoma (WDL)
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| | style="padding: 5px 5px; background: #F5F5F5;" | 4 subtypes:<br>
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| *Lipoma-like<br>
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| *Sclerosing<br>
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| *Spindle cell<br>
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| *Inflammatory<br>
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| Multivacuolated lipoblasts and spindle cells with hyperchromatic nuclei are often observed.<br>Other findings include fibrotic areas and atypical stroma cells.
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| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | De-differentiated Liposarcoma
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| | style="padding: 5px 5px; background: #F5F5F5;" | Abrupt transition from a low-grade to a high-grade differentiation within the same mass of a well-differentiated liposarcoma.
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| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Myxoid liposarcoma
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| | style="padding: 5px 5px; background: #F5F5F5;" |Multinodular mass with round cells and hyaluronic acid matrix.<br>High cellularity at the periphery and low cellularity at the center of the mass. Mitotic activity is normal and the nuclei are normochromatic.
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| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Pleomorphic liposarcoma
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| | style="padding: 5px 5px; background: #F5F5F5;" | Pleomorphic lipoblasts with hyperchromatic nuclei, acidophilic cytoplasm, and eosinophilic hyaline globules.<br>Spindle cells and multinucleated giant cells may be observed.
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| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Mixed-type Liposarcoma
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| | style="padding: 5px 5px; background: #F5F5F5;" | Mixed features of myxoid, pleomorphic, and well-differentiated liposarcoma.
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| | style="padding: 5px 5px; background: #F5F5F5;" colspan=2| <small>Table adapted from Fletcher CDM, Unni KK, Mertens F, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Geneva:IARC Press; 2002<ref>{{cite book | last = Fletcher | first = Christopher | title = Pathology and genetics of tumours of soft tissue and bone | publisher = IARC Press | location = Lyon | year = 2002 | isbn = 9283224132 }}</ref> and Enzinger and Weiss's Soft Tissue Tumors , 6th Edition <ref>{{cite book | last = Goldblum | first = John | title = Enzinger and Weiss's soft tissue tumors | publisher = Saunders/Elsevier | location = Philadelphia, PA | year = 2014 | isbn = 978-0-323-08834-3 }}</ref> </small>
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| {|
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| |[[File:Well Differentiated Liposarcoma.jpg|thumb|250px|Well-differentiated liposarcoma.<br>Retrieved from Wikimedia Commons. Original image courtesy of Panoraia Paraskeva, Paraskevas Katsaronis, Eleftherios D Spartalis, et al. Giant liposarcoma of the back with 4 types of histopathology: a case report. Cases Journal. 2009; 2:9339(Open Access)]]
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| |[[File:Dedifferentiated Liposarcoma.jpg|thumb|250px|De-differentiated liposarcoma.<br>Retrieved from Wikimedia Commons. Image by user: Nephron, licensed under GNU Free Documentation License]]
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| |[[File:Dedifferentiated Liposarcoma 2.jpg|thumb|250px|De-differentiated liposarcoma.<br>Retrieved from Wikimedia Commons. Image by user: Nephron, licensed under GNU Free Documentation License]]
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| |[[File:Dedifferentiated Liposarcoma 3.jpg|thumb|250px|De-differentiated liposarcoma.<br>Retrieved from Wikimedia Commons. Image by user: Nephron, licensed under GNU Free Documentation License]]
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| |[[File:Dedifferentiated Liposarcoma 4.jpg|thumb|250px|De-differentiated liposarcoma.<br>Retrieved from Wikimedia Commons. Image by user: Nephron, licensed under GNU Free Documentation License]]
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| |}
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| ==References== | | ==References== |