Liposarcoma differential diagnosis: Difference between revisions
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Malignant peripheral nerve sheath tumor | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Malignant peripheral nerve sheath tumor | ||
| style="padding: 5px 5px; background: #F5F5F5;" | Generally highly cellular tumors composed of tapering or wavy spindle cells featuring perivascular accentuation and focal S-100– positive immunoreactivity in approximately 50% of cases<ref name="pmid10982304">{{cite journal| author=Dei Tos AP| title=Liposarcoma: new entities and evolving concepts. | journal=Ann Diagn Pathol | year= 2000 | volume= 4 | issue= 4 | pages= 252-66 | pmid=10982304 | doi=10.1053/adpa.2000.8133 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10982304 }} </ref> | | style="padding: 5px 5px; background: #F5F5F5;" | Generally highly cellular tumors composed of tapering or wavy spindle cells featuring perivascular accentuation and focal S-100– positive immunoreactivity in approximately 50% of cases<ref name="pmid10982304">{{cite journal| author=Dei Tos AP| title=Liposarcoma: new entities and evolving concepts. | journal=Ann Diagn Pathol | year= 2000 | volume= 4 | issue= 4 | pages= 252-66 | pmid=10982304 | doi=10.1053/adpa.2000.8133 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10982304 }} </ref> | ||
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{| class="wikitable" | |||
! rowspan="2" |Disease | |||
! colspan="3" |Clinical feature | |||
! rowspan="2" |Laboratory findings | |||
! rowspan="2" |Imaging findings | |||
|- | |||
!Fever | |||
!Weight loss | |||
!Abdominal pain | |||
|- | |||
|[[Retroperitoneal hematoma]] | |||
| | |||
| | |||
|✔ | |||
|[[Anemia]] | |||
| rowspan="4" |[[MRI]] is the best radiologic tool to differentiate between retroperitoneal masses. | |||
|- | |||
|[[Retroperitoneal abscess]] | |||
|✔ | |||
| | |||
|✔ | |||
|[[Leukocytosis]], positive inflammatory markers | |||
|- | |||
|Retroperitoneal tumors (.e.g. [[liposarcoma]]) | |||
|✔ | |||
|✔ | |||
|✔ | |||
|positive [[tumor marker]] | |||
|- | |||
|[[Chronic pancreatitis]] | |||
| | |||
|✔ | |||
|✔ | |||
|[[Diabetes mellitus|DM type II]], [[amylase]] and [[lipase]] levels may be slightly elevated | |||
|} | |} | ||
Revision as of 18:37, 29 July 2017
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Liposarcoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Liposarcoma differential diagnosis On the Web |
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American Roentgen Ray Society Images of Liposarcoma differential diagnosis |
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Risk calculators and risk factors for Liposarcoma differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Liposarcoma must be differentiated from other diseases that cause a painless, growing mass such as spindle cell lipoma, neurofibroma, dermatofibrosarcoma protuberans, and malignant peripheral nerve sheath tumor.
Differential diagnosis
Differential diagnosis of liposarcoma includes nonadipocytic lesions such as:[1]
- Inflammatory myofibroblastic tumor
- Castleman’s disease
- Spindle cell lipoma
- Neurofibroma
- Dermatofibrosarcoma protuberans
- Malignant peripheral nerve sheath tumor
| Disease | Description |
|---|---|
| Spindle cell lipoma | Composed of bland, sometimes palisading, CD34-positive spindle cells, ad- mixed with eosinophilic refractile collagen bundles |
| Neurofibroma | Characterized by a less cellular S-100– positive spindle cell proliferation with wavy nuclei |
| Dermatofibrosarcoma protuberans | Cytologically bland, monomorphic CD34-positive spindle cell proliferation organized in a distinctive storiform growth pattern and characterized by tendency to infiltrate the surrounding fat in a peculiar ‘‘honeycomb’’ pattern |
| Malignant peripheral nerve sheath tumor | Generally highly cellular tumors composed of tapering or wavy spindle cells featuring perivascular accentuation and focal S-100– positive immunoreactivity in approximately 50% of cases[1] |
| Disease | Clinical feature | Laboratory findings | Imaging findings | ||
|---|---|---|---|---|---|
| Fever | Weight loss | Abdominal pain | |||
| Retroperitoneal hematoma | ✔ | Anemia | MRI is the best radiologic tool to differentiate between retroperitoneal masses. | ||
| Retroperitoneal abscess | ✔ | ✔ | Leukocytosis, positive inflammatory markers | ||
| Retroperitoneal tumors (.e.g. liposarcoma) | ✔ | ✔ | ✔ | positive tumor marker | |
| Chronic pancreatitis | ✔ | ✔ | DM type II, amylase and lipase levels may be slightly elevated | ||
References
- ↑ 1.0 1.1 Dei Tos AP (2000). "Liposarcoma: new entities and evolving concepts". Ann Diagn Pathol. 4 (4): 252–66. doi:10.1053/adpa.2000.8133. PMID 10982304.