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*Genes associated with the pathogenesis of oligoastrocytoma and anaplastic oligoastrocytoma include:<ref name="pmid12107116">{{cite journal| author=Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J et al.| title=Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. | journal=Am J Pathol | year= 2002 | volume= 161 | issue= 1 | pages= 313-9 | pmid=12107116 | doi=10.1016/S0002-9440(10)64183-1 | pmc=PMC1850690 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12107116  }} </ref><ref name="pmid25143301">{{cite journal| author=Sahm F, Reuss D, Koelsche C, Capper D, Schittenhelm J, Heim S et al.| title=Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. | journal=Acta Neuropathol | year= 2014 | volume= 128 | issue= 4 | pages= 551-9 | pmid=25143301 | doi=10.1007/s00401-014-1326-7 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25143301  }} </ref><ref name="pmid18507036">{{cite journal| author=Viana-Pereira M, Lopes JM, Little S, Milanezi F, Basto D, Pardal F et al.| title=Analysis of EGFR overexpression, EGFR gene amplification and the EGFRvIII mutation in Portuguese high-grade gliomas. | journal=Anticancer Res | year= 2008 | volume= 28 | issue= 2A | pages= 913-20 | pmid=18507036 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18507036  }} </ref><ref name="pmid12006525">{{cite journal| author=Ermoian RP, Furniss CS, Lamborn KR, Basila D, Berger MS, Gottschalk AR et al.| title=Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival. | journal=Clin Cancer Res | year= 2002 | volume= 8 | issue= 5 | pages= 1100-6 | pmid=12006525 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12006525  }} </ref><ref name="pmid23948976">{{cite journal| author=van den Bent MJ, Erdem-Eraslan L, Idbaih A, de Rooi J, Eilers PH, Spliet WG et al.| title=MGMT-STP27 methylation status as predictive marker for response to PCV in anaplastic Oligodendrogliomas and Oligoastrocytomas. A report from EORTC study 26951. | journal=Clin Cancer Res | year= 2013 | volume= 19 | issue= 19 | pages= 5513-22 | pmid=23948976 | doi=10.1158/1078-0432.CCR-13-1157 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23948976  }} </ref><ref name="pmid22869205">{{cite journal| author=Jiao Y, Killela PJ, Reitman ZJ, Rasheed AB, Heaphy CM, de Wilde RF et al.| title=Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. | journal=Oncotarget | year= 2012 | volume= 3 | issue= 7 | pages= 709-22 | pmid=22869205 | doi= | pmc=PMC3443254 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22869205  }} </ref><ref name="pmid16018821">{{cite journal| author=Liang Y, Bollen AW, Nicholas MK, Gupta N| title=Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. | journal=BMC Clin Pathol | year= 2005 | volume= 5 | issue=  | pages= 6 | pmid=16018821 | doi=10.1186/1472-6890-5-6 | pmc=PMC1182359 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16018821  }} </ref>
*Genes associated with the pathogenesis of oligoastrocytoma and anaplastic oligoastrocytoma include:<ref name="pmid12107116">{{cite journal| author=Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J et al.| title=Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. | journal=Am J Pathol | year= 2002 | volume= 161 | issue= 1 | pages= 313-9 | pmid=12107116 | doi=10.1016/S0002-9440(10)64183-1 | pmc=PMC1850690 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12107116  }} </ref><ref name="pmid25143301">{{cite journal| author=Sahm F, Reuss D, Koelsche C, Capper D, Schittenhelm J, Heim S et al.| title=Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. | journal=Acta Neuropathol | year= 2014 | volume= 128 | issue= 4 | pages= 551-9 | pmid=25143301 | doi=10.1007/s00401-014-1326-7 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25143301  }} </ref><ref name="pmid18507036">{{cite journal| author=Viana-Pereira M, Lopes JM, Little S, Milanezi F, Basto D, Pardal F et al.| title=Analysis of EGFR overexpression, EGFR gene amplification and the EGFRvIII mutation in Portuguese high-grade gliomas. | journal=Anticancer Res | year= 2008 | volume= 28 | issue= 2A | pages= 913-20 | pmid=18507036 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18507036  }} </ref><ref name="pmid12006525">{{cite journal| author=Ermoian RP, Furniss CS, Lamborn KR, Basila D, Berger MS, Gottschalk AR et al.| title=Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival. | journal=Clin Cancer Res | year= 2002 | volume= 8 | issue= 5 | pages= 1100-6 | pmid=12006525 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12006525  }} </ref><ref name="pmid23948976">{{cite journal| author=van den Bent MJ, Erdem-Eraslan L, Idbaih A, de Rooi J, Eilers PH, Spliet WG et al.| title=MGMT-STP27 methylation status as predictive marker for response to PCV in anaplastic Oligodendrogliomas and Oligoastrocytomas. A report from EORTC study 26951. | journal=Clin Cancer Res | year= 2013 | volume= 19 | issue= 19 | pages= 5513-22 | pmid=23948976 | doi=10.1158/1078-0432.CCR-13-1157 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23948976  }} </ref><ref name="pmid22869205">{{cite journal| author=Jiao Y, Killela PJ, Reitman ZJ, Rasheed AB, Heaphy CM, de Wilde RF et al.| title=Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. | journal=Oncotarget | year= 2012 | volume= 3 | issue= 7 | pages= 709-22 | pmid=22869205 | doi= | pmc=PMC3443254 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22869205  }} </ref><ref name="pmid16018821">{{cite journal| author=Liang Y, Bollen AW, Nicholas MK, Gupta N| title=Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. | journal=BMC Clin Pathol | year= 2005 | volume= 5 | issue=  | pages= 6 | pmid=16018821 | doi=10.1186/1472-6890-5-6 | pmc=PMC1182359 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16018821  }} </ref>
:*''[[Isocitrate dehydrogenase|IDH1]]''
:*''[[Isocitrate dehydrogenase|IDH1]]''
:*[[translocation|t(1;19)(q10;p10)]]
:*''[[p53]]''
:*''[[p53]]''
:*''[[EGFR]]''
:*''[[EGFR]]''

Revision as of 21:23, 19 October 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Pathophysiology

Pathogenesis

Genetics

Gross Pathology

  • On gross pathology, oligoastrocytoma is characterized by

Gallery

Microscopic Pathology

On microscopic histopathological analysis, oligoastrocytoma is characterized by:[10][11][12]

  • Highly cellular lesion composed of both oligodendroglial and astrocytic components
  • Oligodendrocytes
    • Fried-egg shaped cells
    • Composed of minigemistocytes
    • Round nucleus
    • Distinct cell borders
    • Moderate-to-marked nuclear atypia with speckled "salt-and-pepper" chromatin pattern with perinuclear halo
  • Astrocytes
    • Composed of gemistocytes
    • Multinucleated giant cells
    • Ovoid nucleus
    • Nuclear atypia

On microscopic histopathological analysis, anaplastic oligoastrocytoma is characterized by:[10][11][12]


Gallery

Immunohistochemistry

Oligoastrocytoma is demonstrated by positivity to tumor markers such as:[13][14][9][15]

References

  1. ↑ Introduction of oligodendroglioma and oligoastrocytoma. American Brain Tumor Association. http://www.abta.org/secure/oligodendrioma-oligo.pdf. Accessed on October 16, 2015
  2. ↑ Mixed Gliomas. Canadian ?Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/brain-and-spinal-tumours/mixed-glioma/?region=on#ixzz3okGrTzyi. Accessed on October 16, 2015
  3. ↑ 3.0 3.1 Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J; et al. (2002). "Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets". Am J Pathol. 161 (1): 313–9. doi:10.1016/S0002-9440(10)64183-1. PMC 1850690. PMID 12107116.
  4. ↑ Sahm F, Reuss D, Koelsche C, Capper D, Schittenhelm J, Heim S; et al. (2014). "Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma". Acta Neuropathol. 128 (4): 551–9. doi:10.1007/s00401-014-1326-7. PMID 25143301.
  5. ↑ Viana-Pereira M, Lopes JM, Little S, Milanezi F, Basto D, Pardal F; et al. (2008). "Analysis of EGFR overexpression, EGFR gene amplification and the EGFRvIII mutation in Portuguese high-grade gliomas". Anticancer Res. 28 (2A): 913–20. PMID 18507036.
  6. ↑ Ermoian RP, Furniss CS, Lamborn KR, Basila D, Berger MS, Gottschalk AR; et al. (2002). "Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival". Clin Cancer Res. 8 (5): 1100–6. PMID 12006525.
  7. ↑ van den Bent MJ, Erdem-Eraslan L, Idbaih A, de Rooi J, Eilers PH, Spliet WG; et al. (2013). "MGMT-STP27 methylation status as predictive marker for response to PCV in anaplastic Oligodendrogliomas and Oligoastrocytomas. A report from EORTC study 26951". Clin Cancer Res. 19 (19): 5513–22. doi:10.1158/1078-0432.CCR-13-1157. PMID 23948976.
  8. ↑ Jiao Y, Killela PJ, Reitman ZJ, Rasheed AB, Heaphy CM, de Wilde RF; et al. (2012). "Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas". Oncotarget. 3 (7): 709–22. PMC 3443254. PMID 22869205.
  9. ↑ 9.0 9.1 Liang Y, Bollen AW, Nicholas MK, Gupta N (2005). "Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas". BMC Clin Pathol. 5: 6. doi:10.1186/1472-6890-5-6. PMC 1182359. PMID 16018821.
  10. ↑ 10.0 10.1 Pathology of oligoastrocytoma. Dr Bruno Di Muzio and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/oligoastrocytoma. Accessed on October 16, 2015
  11. ↑ 11.0 11.1 Naugle DK, Duncan TD, Grice GP (2004). "Oligoastrocytoma". Radiographics. 24 (2): 598–600. doi:10.1148/rg.242035069. PMID 15026604.
  12. ↑ 12.0 12.1 Pathology of oligoastrocytoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligoastrocytoma. Accessed on October 16, 2015
  13. ↑ IHC of oligoastrocytoma. Librepathology 2015. http://librepathology.org/wiki/index.php/Oligoastrocytoma. Accessed on October 16, 2015
  14. ↑ Kolenda-Roberts HM, Harris N, Singletary E, Hardisty JF (2013). "Immunohistochemical characterization of spontaneous and acrylonitrile-induced brain tumors in the rat". Toxicol Pathol. 41 (1): 98–108. doi:10.1177/0192623312452492. PMID 22821367.
  15. ↑ Grier, J. T. (2006). "Low-Grade Gliomas in Adults". The Oncologist. 11 (6): 681–693. doi:10.1634/theoncologist.11-6-681. ISSN 1083-7159.


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