Mast cell leukemia laboratory findings: Difference between revisions
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Total serum tryptase level is elevated in mast cell leukemia.<ref name=wikipedia>Biochemistry of mast cell leukemia. Wikipedia (2015). https://en.wikipedia.org/wiki/Mast_cell_leukemia. Accessed on December 1, 2015</ref> | Total serum tryptase level is elevated in mast cell leukemia.<ref name=wikipedia>Biochemistry of mast cell leukemia. Wikipedia (2015). https://en.wikipedia.org/wiki/Mast_cell_leukemia. Accessed on December 1, 2015</ref> | ||
===Immunohistochemistry=== | ===Immunohistochemistry=== | ||
On immunohistochemistry, characteristic findings of mast cell leukemia include: | |||
*CD2 +ve | |||
*CD25 +ve | |||
*CD117 | |||
*CD11c | |||
*CD13 | |||
*CD29 | |||
*CD33 | |||
*CD44 | |||
*CD45 | |||
*CD63 | |||
*CD68 | |||
*CD71 | |||
*CD2 | |||
*CD22 | |||
*CD54 | |||
==References== | ==References== | ||
{{Reflist|1}} | {{Reflist|1}} | ||
Revision as of 13:16, 1 December 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
Mast cell leukemia laboratory findings
Laboratory findings consistent with the diagnosis of mast cell leukemia include abnormal complete blood count, immunohistochemistry, and flow cytometry.[1]
Complete Blood Count
- Bicytopenia
- Anemia
- Thrombocytopenia
- Leukopenia
- Neutropenia
Biochemistry
Total serum tryptase level is elevated in mast cell leukemia.[2]
Immunohistochemistry
On immunohistochemistry, characteristic findings of mast cell leukemia include:
- CD2 +ve
- CD25 +ve
- CD117
- CD11c
- CD13
- CD29
- CD33
- CD44
- CD45
- CD63
- CD68
- CD71
- CD2
- CD22
- CD54
References
- ↑ Joris, Magalie; Georgin-Lavialle, Sophie; Chandesris, Marie-Olivia; Lhermitte, Ludovic; Claisse, Jean-François; Canioni, Danielle; Hanssens, Katia; Damaj, Gandhi; Hermine, Olivier; Hamidou, Mohammed (2012). "Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive". Case Reports in Hematology. 2012: 1–6. doi:10.1155/2012/517546. ISSN 2090-6560.
- ↑ Biochemistry of mast cell leukemia. Wikipedia (2015). https://en.wikipedia.org/wiki/Mast_cell_leukemia. Accessed on December 1, 2015