Hemophilia A laboratory findings: Difference between revisions
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:*Normal [[bleeding time]] | :*Normal [[bleeding time]] | ||
:*Normal [[fibrinogen]] level | :*Normal [[fibrinogen]] level | ||
:*Low [[factor | :*Low [[factor VIII]] | ||
Other laboratory findings consistent with the diagnosis of hemophilia A include correction of the PTT with a 1:1 mixing study (i.e. factor VIII from the normal blood mixed with the hemophiliac blood is able to correct for the coagulation deficit) | |||
==References== | ==References== | ||
Revision as of 22:17, 29 July 2016
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Hemophilia A Microchapters |
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Hemophilia A laboratory findings On the Web |
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American Roentgen Ray Society Images of Hemophilia A laboratory findings |
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Risk calculators and risk factors for Hemophilia A laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
The diagnosis may be suspected as coagulation testing reveals an increased PTT in the context of a normal PT and bleeding time. The diagnosis is made in the presence of very low (<10 IU) levels of factor VIII. A very small minority of patients has antibodies against factor VIII that impair its functioning. Management of these patients is more complicated.
- Prolonged partial thromboplastin time (PTT)
- Normal prothrombin time
- Normal bleeding time
- Normal fibrinogen level
- Low factor VIII
Other laboratory findings consistent with the diagnosis of hemophilia A include correction of the PTT with a 1:1 mixing study (i.e. factor VIII from the normal blood mixed with the hemophiliac blood is able to correct for the coagulation deficit)