Uveitis natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Tarek Nafee, M.D. [2]

Natural history

When left untreated, uveitis can lead to permanent vision loss. Additionally, a more serious, potentially life-threatening medical condition could worsen if the uveitis is caused by an underlying disorder that is left untreated. Uveitis is estimated to be responsible for approximately 10% of the blindness in the United States.

Complications

Possible complications of uveitis include:

• Cataracts
• Fluid within the retina
• Glaucoma
• Retinal detachment
• Vision loss

Prognosis

The prognosis is generally good for those who receive prompt diagnosis and treatment, but serious complication (including cataracts, glaucoma, band keratopathy, retinal edema and permanent vision loss) may result if left untreated. The type of uveitis, as well as its severity, duration, and responsiveness to treatment or any associated illnesses, all factor come into the outlook. With proper treatment, most attacks of anterior uveitis go away in a few days to weeks. However, relapses are common. Inflammation related to posterior uveitis may last from months to years and may cause permanent vision damage, even with treatment.