Goodpasture syndrome laboratory findings: Difference between revisions
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===Renal Biopsy=== | ===Renal Biopsy=== | ||
Renal biopsy is the gold standard in establishing Goodpasture syndrome.<ref name="pmid22218111">{{cite journal| author=Alenzi FQ, Salem ML, Alenazi FA, Wyse RK| title=Cellular and molecular aspects of Goodpasture syndrome. | journal=Iran J Kidney Dis | year= 2012 | volume= 6 | issue= 1 | pages= 1-8 | pmid=22218111 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22218111 }} </ref> As it can help establish the detection of circulating anti-glomerular basement membrane antibodies. It is of note that a renal biopsy is best over a pulmonary biopsy because of abundance of autofluorecene. Renal biopsy reveals early focal proliferative changes that present with necrosis, crescent formation, and inflammation of the interstitial under light microscopy. Under direct immunofluorescence, linear immunoglobulin G (IgG) deposits are seen encompassing the glomerular basement membrane and at times the distal tubular portion. | Renal biopsy is the gold standard in establishing Goodpasture syndrome.<ref name="pmid22218111">{{cite journal| author=Alenzi FQ, Salem ML, Alenazi FA, Wyse RK| title=Cellular and molecular aspects of Goodpasture syndrome. | journal=Iran J Kidney Dis | year= 2012 | volume= 6 | issue= 1 | pages= 1-8 | pmid=22218111 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22218111 }} </ref> As it can help establish the detection of circulating anti-glomerular basement membrane antibodies. It is of note that a renal biopsy is best over a pulmonary biopsy because of abundance of autofluorecene. <ref name="pmid12815141">{{cite journal| author=Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG| title=Alport's syndrome, Goodpasture's syndrome, and type IV collagen. | journal=N Engl J Med | year= 2003 | volume= 348 | issue= 25 | pages= 2543-56 | pmid=12815141 | doi=10.1056/NEJMra022296 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12815141 }}</ref> Renal biopsy reveals early focal proliferative changes that present with necrosis, crescent formation, and inflammation of the interstitial under light microscopy. Under direct immunofluorescence, linear immunoglobulin G (IgG) deposits are seen encompassing the glomerular basement membrane and at times the distal tubular portion.<ref name="pmid25462583">{{cite journal| author=Greco A, Rizzo MI, De Virgilio A, Gallo A, Fusconi M, Pagliuca G et al.| title=Goodpasture's syndrome: a clinical update. | journal=Autoimmun Rev | year= 2015 | volume= 14 | issue= 3 | pages= 246-53 | pmid=25462583 | doi=10.1016/j.autrev.2014.11.006 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25462583 }}</ref> | ||
Revision as of 15:04, 4 November 2016
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Goodpasture syndrome Microchapters |
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Goodpasture syndrome laboratory findings On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]
Overview
Laboratory findings consistent with the diagnosis of Goodpasture syndrome include, anti-glomerular basement membrane antibodies elevated blood urea nitrogen, low-grade proteinuria, leukocytosis, gross or microscopic hematuria, and red cell casts.
Laboratory Findings
Laboratory findings consistent with the diagnosis of Goodpasture syndrome include, anti-glomerular basement membrane antibodies, elevated blood urea nitrogen, low-grade proteinuria, leukocytosis, gross or microscopic hematuria, and red cell casts. If laboratory findings do not show anti-glomerular basement membrane antibodies, a test for anti-neutrophil cytoplasmic antibodies should be made to determine possible cause of ANCA associated vasculitis. Routine laboratory test that may be ordered to help in identifying the cause are:
Blood Work-up
- Complete blood count (CBC)
- Uremia
- Serum creatinine
- Blood urea nitrogen (BUN)
- Anti-glomerular basement membrane test
- Anti-neutrophil cytoplasmic antibody test
Urinalysis
- Proteinuria
- Hematuria
- Red cell casts
Renal Biopsy
Renal biopsy is the gold standard in establishing Goodpasture syndrome.[1] As it can help establish the detection of circulating anti-glomerular basement membrane antibodies. It is of note that a renal biopsy is best over a pulmonary biopsy because of abundance of autofluorecene. [2] Renal biopsy reveals early focal proliferative changes that present with necrosis, crescent formation, and inflammation of the interstitial under light microscopy. Under direct immunofluorescence, linear immunoglobulin G (IgG) deposits are seen encompassing the glomerular basement membrane and at times the distal tubular portion.[3]
References
- ↑ Alenzi FQ, Salem ML, Alenazi FA, Wyse RK (2012). "Cellular and molecular aspects of Goodpasture syndrome". Iran J Kidney Dis. 6 (1): 1–8. PMID 22218111.
- ↑ Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG (2003). "Alport's syndrome, Goodpasture's syndrome, and type IV collagen". N Engl J Med. 348 (25): 2543–56. doi:10.1056/NEJMra022296. PMID 12815141.
- ↑ Greco A, Rizzo MI, De Virgilio A, Gallo A, Fusconi M, Pagliuca G; et al. (2015). "Goodpasture's syndrome: a clinical update". Autoimmun Rev. 14 (3): 246–53. doi:10.1016/j.autrev.2014.11.006. PMID 25462583.