Bourbon virus infection pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
*Virus attaches to sialic acid | ===Replication=== | ||
*Endosome acidification induces fusion of virus membrane with the vesicle membrane | *Virus attaches to the sialic acid receptors on the host cell through glycoprotein | ||
*The virus gets endocytosed by clathrins into the host cell. | |||
*Endosome acidification induces fusion of virus membrane with the vesicle membrane. | |||
*Encapsidated RNA segments migrate to the nucleus. | *Encapsidated RNA segments migrate to the nucleus. | ||
*Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase. | *Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase. | ||
Revision as of 14:54, 13 July 2017
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Bourbon virus infection Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Bourbon virus infection pathophysiology On the Web |
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American Roentgen Ray Society Images of Bourbon virus infection pathophysiology |
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Risk calculators and risk factors for Bourbon virus infection pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Pathophysiology
Replication
- Virus attaches to the sialic acid receptors on the host cell through glycoprotein
- The virus gets endocytosed by clathrins into the host cell.
- Endosome acidification induces fusion of virus membrane with the vesicle membrane.
- Encapsidated RNA segments migrate to the nucleus.
- Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase.
- Replication of genomic segments.
- High level of M1 protein induces genomes segments export from nucleus by NEP protein.
- Virus assembly and budding occurs at the plasma membrane.