Bourbon virus infection pathophysiology: Difference between revisions
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*High level of M1 protein induces genomes segments export from nucleus by NEP protein. | *High level of M1 protein induces genomes segments export from nucleus by NEP protein. | ||
*Virus assembly and budding occurs at the plasma membrane. | *Virus assembly and budding occurs at the plasma membrane. | ||
===Associated Conditions=== | ===Associated Conditions=== | ||
Revision as of 15:27, 13 July 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2] Aravind Reddy Kothagadi M.B.B.S[3]
Overview
Pathophysiology
Replication
- Virus attaches to the sialic acid receptors on the host cell through glycoprotein.[1]
- The virus gets endocytosed by clathrins into the host cell.
- Endosome acidification induces fusion of virus membrane with the vesicle membrane.
- Encapsidated RNA segments migrate to the nucleus.
- Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase.
- Replication of genomic segments.
- High level of M1 protein induces genomes segments export from nucleus by NEP protein.
- Virus assembly and budding occurs at the plasma membrane.
Associated Conditions
Few rare conditions associated with bourbon virus infection are: [2]
- Neuromyelitis optica
- Meningitis
References
- ↑ "Receptor-Mediated Endocytosis and the Sorting of Internalized Proteins - Molecular Cell Biology - NCBI Bookshelf".
- ↑ Kosoy OI, Lambert AJ, Hawkinson DJ, Pastula DM, Goldsmith CS, Hunt DC, Staples JE (2015). "Novel thogotovirus associated with febrile illness and death, United States, 2014". Emerging Infect. Dis. 21 (5): 760–4. doi:10.3201/eid2105.150150. PMC 4412252. PMID 25899080.