Bourbon virus infection pathophysiology: Difference between revisions
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{{Bourbon virus infection}} | {{Bourbon virus infection}} | ||
{{CMG}}; {{AE}} {{HK}} | {{CMG}}; {{AE}} {{HK}} | ||
==Overview== | ==Overview== | ||
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*High level of M1 protein induces genomes segments export from nucleus by NEP protein. | *High level of M1 protein induces genomes segments export from nucleus by NEP protein. | ||
*Virus assembly and budding occurs at the plasma membrane. | *Virus assembly and budding occurs at the plasma membrane. | ||
==References== | ==References== | ||
Revision as of 15:27, 13 July 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]
Overview
Pathophysiology
Replication
- Virus attaches to the sialic acid receptors on the host cell through glycoprotein.[1]
- The virus gets endocytosed by clathrins into the host cell.
- Endosome acidification induces fusion of virus membrane with the vesicle membrane.
- Encapsidated RNA segments migrate to the nucleus.
- Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase.
- Replication of genomic segments.
- High level of M1 protein induces genomes segments export from nucleus by NEP protein.
- Virus assembly and budding occurs at the plasma membrane.