Secondary adrenal insufficiency pathophysiology: Difference between revisions
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*Secondary adrenal insufficiency is also caused by genetic disorders. | *Secondary adrenal insufficiency is also caused by genetic disorders. | ||
**Combined pituitary hormone deficiency (CPHD) | **Combined pituitary hormone deficiency (CPHD) | ||
**[[Proopiomelanocortin]] deficiency ([[POMC]]) | **[[Proopiomelanocortin]] deficiency ([[POMC]])<ref name="urlProopiomelanocortin Deficiency - GeneReviews® - NCBI Bookshelf">{{cite web |url=https://www.ncbi.nlm.nih.gov/books/NBK174451/ |title=Proopiomelanocortin Deficiency - GeneReviews® - NCBI Bookshelf |format= |work= |accessdate=}}</ref> | ||
*POMC deficiency is transmitted in [autosomal recessive] transmission pattern. | *POMC deficiency is transmitted in [[autosomal recessive]] transmission pattern. | ||
*Genes involved in the pathogenesis of [[POMC]] deficiency include [[POMC]] gene. | *Genes involved in the pathogenesis of [[POMC]] deficiency include [[POMC]] gene. | ||
*The development of [disease name] is the result of multiple genetic mutations. | *The development of [disease name] is the result of multiple genetic mutations. | ||
Revision as of 18:11, 9 October 2017
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Adrenal insufficiency Microchapters |
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Secondary adrenal insufficiency pathophysiology On the Web |
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American Roentgen Ray Society Images of Secondary adrenal insufficiency pathophysiology |
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Risk calculators and risk factors for Secondary adrenal insufficiency pathophysiology |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The exact pathogenesis of [disease name] is not fully understood.
OR
It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
OR
[Pathogen name] is usually transmitted via the [transmission route] route to the human host.
OR
Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
OR
[Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
OR
The progression to [disease name] usually involves the [molecular pathway].
OR
The pathophysiology of [disease/malignancy] depends on the histological subtype.
Pathophysiology
Pathogenesis
- Secondary adrenal insufficiency is caused by the processes occurring outside adrenal glands: pituitary causes, drugs, genetic causes.
- These disease processes causes the decreased production of adrenocorticotrophic hormone (ACTH)
- In drugs, chronic steroid therapy causes suppression of hypothalamic-pituitary-adrenal (HPA) axis.
Genetics
- Secondary adrenal insufficiency is also caused by genetic disorders.
- Combined pituitary hormone deficiency (CPHD)
- Proopiomelanocortin deficiency (POMC)[1]
- POMC deficiency is transmitted in autosomal recessive transmission pattern.
- Genes involved in the pathogenesis of POMC deficiency include POMC gene.
- The development of [disease name] is the result of multiple genetic mutations.
Associated Conditions
Gross Pathology
- On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
- On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].