Postpartum thyroiditis laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
Laboratory findings consistent with the diagnosis of PPT depend on the phase of disease and include screening of serum [[TSH]], serum free [[T4]], serum free [[T3]], serum | Laboratory findings consistent with the diagnosis of PPT depend on the phase of disease and include screening of serum [[TSH]], serum free [[T4]], serum free [[T3]], serum anti-[[Thyroid peroxidase|TPO]] anitbodies, serum [[TSH]]-receptor abs, serum [[ESR]], serum thyroglobulin Tg and radio-iodine uptake. Some patients with PPT may have elevated concentration of serum anti-[[Thyroid peroxidase|TPO]] abs, which is usually suggestive of future hypothyroidism. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
Some patients with PPT may have elevated concentration of serum | Some patients with PPT may have elevated concentration of serum anti-[[Thyroid peroxidase|TPO]] abs, which is usually suggestive of future hypothyroidism. Laboratory findings consistent with the diagnosis of PPT depend on the phase of disease and include:<ref name="pmid11588143">{{cite journal| author=Muller AF, Drexhage HA, Berghout A| title=Postpartum thyroiditis and autoimmune thyroiditis in women of childbearing age: recent insights and consequences for antenatal and postnatal care. | journal=Endocr Rev | year= 2001 | volume= 22 | issue= 5 | pages= 605-30 | pmid=11588143 | doi=10.1210/edrv.22.5.0441 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11588143 }} </ref><ref name="pmid25434070">{{cite journal| author=Argatska AB, Nonchev BI| title=Postpartum thyroiditis. | journal=Folia Med (Plovdiv) | year= 2014 | volume= 56 | issue= 3 | pages= 145-51 | pmid=25434070 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25434070 }} </ref><ref name="pmid22312089">{{cite journal| author=Stagnaro-Green A| title=Approach to the patient with postpartum thyroiditis. | journal=J Clin Endocrinol Metab | year= 2012 | volume= 97 | issue= 2 | pages= 334-42 | pmid=22312089 | doi=10.1210/jc.2011-2576 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22312089 }} </ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
!Laboratory Tests | !Laboratory Tests | ||
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|Decreased | |Decreased | ||
|- | |- | ||
|Serum | |Serum anti-[[TPO|Thyroid peroxidase]] anitbodies | ||
|Positive | |Positive | ||
|Postive | |Postive | ||
Latest revision as of 18:01, 10 November 2017
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Postpartum thyroiditis laboratory findings On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sunny Kumar MD [2]
Overview
Laboratory findings consistent with the diagnosis of PPT depend on the phase of disease and include screening of serum TSH, serum free T4, serum free T3, serum anti-TPO anitbodies, serum TSH-receptor abs, serum ESR, serum thyroglobulin Tg and radio-iodine uptake. Some patients with PPT may have elevated concentration of serum anti-TPO abs, which is usually suggestive of future hypothyroidism.
Laboratory Findings
Some patients with PPT may have elevated concentration of serum anti-TPO abs, which is usually suggestive of future hypothyroidism. Laboratory findings consistent with the diagnosis of PPT depend on the phase of disease and include:[1][2][3]
| Laboratory Tests | Hyperthyroid phase | Hypothyroid phase |
|---|---|---|
| Serum TSH | Less than 3.5 micrograms/dl | More than 3.5 micrograms/dl |
| Serum free T4 | Elevated but may be normal | Decreased |
| Serum free T3 | Elevated or normal | Decreased |
| Serum anti-Thyroid peroxidase anitbodies | Positive | Postive |
| Serum TSH-receptor abs | Negative or positive with coexisting Grave's disease | Negative |
| Serum ESR | Normal | Normal |
| Serum thyroglobulin Tg | Elevated in early phase of destruction of follicles | Elevated in early phase of destruction of follicles |
| Radio-iodine uptake | Decreased | Decreased |
References
- ↑ Muller AF, Drexhage HA, Berghout A (2001). "Postpartum thyroiditis and autoimmune thyroiditis in women of childbearing age: recent insights and consequences for antenatal and postnatal care". Endocr Rev. 22 (5): 605–30. doi:10.1210/edrv.22.5.0441. PMID 11588143.
- ↑ Argatska AB, Nonchev BI (2014). "Postpartum thyroiditis". Folia Med (Plovdiv). 56 (3): 145–51. PMID 25434070.
- ↑ Stagnaro-Green A (2012). "Approach to the patient with postpartum thyroiditis". J Clin Endocrinol Metab. 97 (2): 334–42. doi:10.1210/jc.2011-2576. PMID 22312089.