Receptor tyrosine kinase-like orphan receptor: Difference between revisions
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{{Infobox protein family | |||
| Symbol = ROR | |||
| Name = Receptor tyrosine kinase-like orphan receptor | |||
| image = | |||
| width = | |||
| caption = | |||
| Pfam= | |||
| InterPro= IPR016247 | |||
| SMART= | |||
| Prosite = | |||
| SCOP = | |||
| TCDB = | |||
| OPM family= | |||
| OPM protein= | |||
| PDB= | |||
| Membranome family = 720 | |||
}} | |||
{{infobox protein | {{infobox protein | ||
| Name = [[ROR1|receptor tyrosine kinase-like orphan receptor 1]] | | Name = [[ROR1|receptor tyrosine kinase-like orphan receptor 1]] | ||
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| LocusSupplementaryData = | | LocusSupplementaryData = | ||
}} | }} | ||
In the field of [[molecular biology]], '''receptor tyrosine kinase-like orphan receptors''' ('''RORs''') are a family of [[tyrosine kinase receptor]]s that are important in regulating skeletal and neuronal development, [[cell migration]] and [[Cell migration# | In the field of [[molecular biology]], '''receptor tyrosine kinase-like orphan receptors''' ('''RORs''') are a family of [[tyrosine kinase receptor]]s that are important in regulating skeletal and neuronal development, [[cell migration]] and [[Cell migration#Polarity in migrating cells|cell polarity]]. ROR proteins ([[ROR1]] and [[ROR2]] in humans) can modulate [[Wnt signaling pathway|Wnt signaling]] by sequestering [[Wnt signaling pathway#Ligands which act on Wnt signaling|Wnt ligand]]s.<ref name="pmid18848778">{{cite journal |vauthors=Green JL, Kuntz SG, Sternberg PW | title = Ror receptor tyrosine kinases: orphans no more | journal = Trends Cell Biol. | volume = 18 | issue = 11 | pages = 536–44 |date=November 2008 | pmid = 18848778 | doi = 10.1016/j.tcb.2008.08.006 | url = | issn = | pmc = 4672995 }}</ref> | ||
== References == | == References == | ||
Revision as of 23:45, 13 August 2018
| Receptor tyrosine kinase-like orphan receptor | |
|---|---|
| Identifiers | |
| Symbol | ROR |
| InterPro | IPR016247 |
| Membranome | 720 |
| receptor tyrosine kinase-like orphan receptor 1 | |
|---|---|
| Identifiers | |
| Symbol | ROR1 |
| Alt. symbols | NTRKR1 |
| Entrez | 4919 |
| HUGO | 10256 |
| OMIM | 602336 |
| RefSeq | NM_005012 |
| UniProt | Q01973 |
| Other data | |
| EC number | 2.7.10.1 |
| Locus | Chr. 1 p32-p31 |
| receptor tyrosine kinase-like orphan receptor 2 | |
|---|---|
| Identifiers | |
| Symbol | ROR2 |
| Alt. symbols | NTRKR2, BDB, BDB1 |
| Entrez | 4920 |
| HUGO | 10257 |
| OMIM | 602337 |
| RefSeq | NM_004560 |
| UniProt | Q01974 |
| Other data | |
| Locus | Chr. 9 q22 |
In the field of molecular biology, receptor tyrosine kinase-like orphan receptors (RORs) are a family of tyrosine kinase receptors that are important in regulating skeletal and neuronal development, cell migration and cell polarity. ROR proteins (ROR1 and ROR2 in humans) can modulate Wnt signaling by sequestering Wnt ligands.[1]
References
- ↑ Green JL, Kuntz SG, Sternberg PW (November 2008). "Ror receptor tyrosine kinases: orphans no more". Trends Cell Biol. 18 (11): 536–44. doi:10.1016/j.tcb.2008.08.006. PMC 4672995. PMID 18848778.