FGR (gene): Difference between revisions
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* {{cite journal | vauthors = Lowell CA, Berton G | title = Integrin signal transduction in myeloid leukocytes | journal = Journal of Leukocyte Biology | volume = 65 | issue = 3 | pages = 313–20 | date = Mar 1999 | pmid = 10080533 | doi = }} | * {{cite journal | vauthors = Lowell CA, Berton G | title = Integrin signal transduction in myeloid leukocytes | journal = Journal of Leukocyte Biology | volume = 65 | issue = 3 | pages = 313–20 | date = Mar 1999 | pmid = 10080533 | doi = }} | ||
* {{cite journal | vauthors = Snapper SB, Rosen FS | title = The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization | journal = Annual Review of Immunology | volume = 17 | issue = 1 | pages = 905–29 | year = 1999 | pmid = 10358777 | doi = 10.1146/annurev.immunol.17.1.905 }} | * {{cite journal | vauthors = Snapper SB, Rosen FS | title = The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization | journal = Annual Review of Immunology | volume = 17 | issue = 1 | pages = 905–29 | year = 1999 | pmid = 10358777 | doi = 10.1146/annurev.immunol.17.1.905 }} | ||
* {{cite journal | vauthors = Tatosyan AG, Mizenina OA | title = Kinases of the Src family: structure and functions | journal = Biochemistry. | * {{cite journal | vauthors = Tatosyan AG, Mizenina OA | title = Kinases of the Src family: structure and functions | journal = Biochemistry. Biokhimiia | volume = 65 | issue = 1 | pages = 49–58 | date = Jan 2000 | pmid = 10702640 | doi = }} | ||
* {{cite journal | vauthors = Patel MS, Mankoo BS, Brickell PM | title = A polymorphic microsatellite repeat is located close to the promoter region of the c-fgr proto-oncogene (FGR) at chromosome 1p36.2-p36.1 | journal = Human Molecular Genetics | volume = 1 | issue = 1 | pages = 65 | date = Apr 1992 | pmid = 1339476 | doi = 10.1093/hmg/1.1.65-a }} | * {{cite journal | vauthors = Patel MS, Mankoo BS, Brickell PM | title = A polymorphic microsatellite repeat is located close to the promoter region of the c-fgr proto-oncogene (FGR) at chromosome 1p36.2-p36.1 | journal = Human Molecular Genetics | volume = 1 | issue = 1 | pages = 65 | date = Apr 1992 | pmid = 1339476 | doi = 10.1093/hmg/1.1.65-a }} | ||
* {{cite journal | vauthors = Link DC, Gutkind SJ, Robbins KC, Ley TJ | title = Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter | journal = Oncogene | volume = 7 | issue = 5 | pages = 877–84 | date = May 1992 | pmid = 1373875 | doi = }} | * {{cite journal | vauthors = Link DC, Gutkind SJ, Robbins KC, Ley TJ | title = Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter | journal = Oncogene | volume = 7 | issue = 5 | pages = 877–84 | date = May 1992 | pmid = 1373875 | doi = }} | ||
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Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as FGR, is a protein which in humans is encoded by the FGR gene.[1][2]
Function
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristoylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.[2]
Discovery
The feline version of this gene was discovered by Suraiya Rasheed, Murray Gardner, and co-workers.[3]
Interactions
FGR (gene) has been shown to interact with Wiskott-Aldrich syndrome protein.[4][5][6]
References
- ↑ Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo JA, Robbins KC (Oct 1985). "of Sciences of the United States of America". 82 (19): 6595–9. doi:10.1073/pnas.82.19.6595. PMC 391256. PMID 2995972.
- ↑ 2.0 2.1 "Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog".
- ↑ Rasheed S, Barbacid M, Aaronson S, Gardner MB (Feb 1982). "Origin and biological properties of a new feline sarcoma virus". Virology. 117 (1): 238–44. doi:10.1016/0042-6822(82)90522-0. PMID 6175084.
- ↑ Banin S, Truong O, Katz DR, Waterfield MD, Brickell PM, Gout I (Aug 1996). "Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases". Current Biology. 6 (8): 981–8. doi:10.1016/S0960-9822(02)00642-5. PMID 8805332.
- ↑ Finan PM, Soames CJ, Wilson L, Nelson DL, Stewart DM, Truong O, Hsuan JJ, Kellie S (Oct 1996). "Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains". The Journal of Biological Chemistry. 271 (42): 26291–5. doi:10.1074/jbc.271.42.26291. PMID 8824280.
- ↑ Rivero-Lezcano OM, Marcilla A, Sameshima JH, Robbins KC (Oct 1995). "Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains". Molecular and Cellular Biology. 15 (10): 5725–31. PMC 230823. PMID 7565724.
Further reading
- Patel M, Faulkner L, Katz DR, Brickell PM (1991). "The c-fgr proto-oncogene: expression in Epstein-Barr-virus-infected B lymphocytes and in cells of the myelomonocytic and granulocytic lineages". Pathobiology. 59 (4): 289–92. doi:10.1159/000163665. PMID 1652975.
- Resh MD (Feb 1994). "Myristylation and palmitylation of Src family members: the fats of the matter". Cell. 76 (3): 411–3. doi:10.1016/0092-8674(94)90104-X. PMID 8313462.
- Lowell CA, Berton G (Mar 1999). "Integrin signal transduction in myeloid leukocytes". Journal of Leukocyte Biology. 65 (3): 313–20. PMID 10080533.
- Snapper SB, Rosen FS (1999). "The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization". Annual Review of Immunology. 17 (1): 905–29. doi:10.1146/annurev.immunol.17.1.905. PMID 10358777.
- Tatosyan AG, Mizenina OA (Jan 2000). "Kinases of the Src family: structure and functions". Biochemistry. Biokhimiia. 65 (1): 49–58. PMID 10702640.
- Patel MS, Mankoo BS, Brickell PM (Apr 1992). "A polymorphic microsatellite repeat is located close to the promoter region of the c-fgr proto-oncogene (FGR) at chromosome 1p36.2-p36.1". Human Molecular Genetics. 1 (1): 65. doi:10.1093/hmg/1.1.65-a. PMID 1339476.
- Link DC, Gutkind SJ, Robbins KC, Ley TJ (May 1992). "Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter". Oncogene. 7 (5): 877–84. PMID 1373875.
- Patel M, Leevers SJ, Brickell PM (Feb 1990). "Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites". Oncogene. 5 (2): 201–6. PMID 1690869.
- Biondi A, Paganin C, Rossi V, Benvestito S, Perlmutter RM, Mantovani A, Allavena P (Mar 1991). "Expression of lineage-restricted protein tyrosine kinase genes in human natural killer cells". European Journal of Immunology. 21 (3): 843–6. doi:10.1002/eji.1830210348. PMID 1826268.
- Gutkind JS, Link DC, Katamine S, Lacal P, Miki T, Ley TJ, Robbins KC (Mar 1991). "A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes". Molecular and Cellular Biology. 11 (3): 1500–7. PMC 369433. PMID 1847500.
- Patel M, Leevers SJ, Brickell PM (Feb 1990). "Regulation of c-fgr proto-oncogene expression in Epstein-Barr virus infected B-cell lines". International Journal of Cancer. 45 (2): 342–6. doi:10.1002/ijc.2910450222. PMID 2154410.
- Parker RC, Mardon G, Lebo RV, Varmus HE, Bishop JM (Apr 1985). "Isolation of duplicated human c-src genes located on chromosomes 1 and 20". Molecular and Cellular Biology. 5 (4): 831–8. PMC 366788. PMID 2581127.
- Brickell PM, Patel M (Dec 1988). "Structure and expression of c-fgr protooncogene mRNA in Epstein-Barr virus converted cell lines". British Journal of Cancer. 58 (6): 704–9. doi:10.1038/bjc.1988.294. PMC 2246855. PMID 2852026.
- Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo JA, Robbins KC (Oct 1985). "Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family". Proceedings of the National Academy of Sciences of the United States of America. 82 (19): 6595–9. doi:10.1073/pnas.82.19.6595. PMC 391256. PMID 2995972.
- Cheah MS, Ley TJ, Tronick SR, Robbins KC (1986). "fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection". Nature. 319 (6050): 238–40. doi:10.1038/319238a0. PMID 3003578.
- Nishizawa M, Semba K, Yoshida MC, Yamamoto T, Sasaki M, Toyoshima K (Feb 1986). "Structure, expression, and chromosomal location of the human c-fgr gene". Molecular and Cellular Biology. 6 (2): 511–7. PMC 367540. PMID 3023853.
- Katamine S, Notario V, Rao CD, Miki T, Cheah MS, Tronick SR, Robbins KC (Jan 1988). "Primary structure of the human fgr proto-oncogene product p55c-fgr". Molecular and Cellular Biology. 8 (1): 259–66. PMC 363113. PMID 3275868.
- Inoue K, Ikawa S, Semba K, Sukegawa J, Yamamoto T, Toyoshima K (1988). "Isolation and sequencing of cDNA clones homologous to the v-fgr oncogene from a human B lymphocyte cell line, IM-9". Oncogene. 1 (3): 301–4. PMID 3330776.
- Nishizawa M, Semba K, Yamamoto T, Toyoshima K (Mar 1985). "Human c-f gr gene does not contain coding sequence for actin-like protein". Japanese Journal of Cancer Research. 76 (3): 155–9. PMID 3922831.
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