NCOA4: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''Nuclear receptor coactivator 4''' is a [[protein]] that in humans is encoded by the ''NCOA4'' [[gene]].<ref name="pmid8290261">{{cite journal | vauthors = Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A | title = Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma | journal = Oncogene | volume = 9 | issue = 2 | pages = 509–16 | date = Feb 1994 | pmid = 8290261 | pmc =  | doi =  }}</ref><ref name="pmid8643607">{{cite journal | vauthors = Yeh S, Chang C | title = Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 11 | pages = 5517–21 | date = May 1996 | pmid = 8643607 | pmc = 39278 | doi = 10.1073/pnas.93.11.5517 }}</ref><ref>{{cite web | title = Entrez Gene: NCOA4 Nuclear receptor coactivator 4 |url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8031| accessdate = }}</ref>
'''Nuclear receptor coactivator 4''' is a [[protein]] that in humans is encoded by the ''NCOA4'' [[gene]].<ref name="pmid8290261">{{cite journal | vauthors = Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A | title = Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma | journal = Oncogene | volume = 9 | issue = 2 | pages = 509–16 | date = February 1994 | pmid = 8290261 | pmc =  | doi =  }}</ref><ref name="pmid8643607">{{cite journal | vauthors = Yeh S, Chang C | title = Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 11 | pages = 5517–21 | date = May 1996 | pmid = 8643607 | pmc = 39278 | doi = 10.1073/pnas.93.11.5517 }}</ref><ref>{{cite web | title = Entrez Gene: NCOA4 Nuclear receptor coactivator 4 |url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8031| accessdate = }}</ref> It plays an important role in ferritinophagy, acting as a cargo receptor, binding to the ferritin heavy chain and latching on to ATG8 on the surface of the autophagosome.


== Interactions ==
== Interactions ==


NCOA4 has been shown to [[Protein-protein interaction|interact]] with:
NCOA4 has been shown to [[Protein-protein interaction|interact]] with:
* [[Androgen receptor]],<ref name = pmid8643607 /><ref name = pmid9892017>{{cite journal | vauthors = Alen P, Claessens F, Schoenmakers E, Swinnen JV, Verhoeven G, Rombauts W, Peeters B | title = Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform | journal = Molecular Endocrinology | volume = 13 | issue = 1 | pages = 117–28 | date = Jan 1999 | pmid = 9892017 | doi = 10.1210/mend.13.1.0214 }}</ref><ref name = pmid9636157>{{cite journal | vauthors = Miyamoto H, Yeh S, Wilding G, Chang C | title = Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 13 | pages = 7379–84 | date = Jun 1998 | pmid = 9636157 | pmc = 22623 | doi = 10.1073/pnas.95.13.7379 }}</ref><ref name = pmid11404460>{{cite journal | vauthors = Lin HK, Yeh S, Kang HY, Chang C | title = Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 13 | pages = 7200–5 | date = Jun 2001 | pmid = 11404460 | pmc = 34646 | doi = 10.1073/pnas.121173298 }}</ref><ref name = pmid10318905>{{cite journal | vauthors = Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C | title = From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 10 | pages = 5458–63 | date = May 1999 | pmid = 10318905 | pmc = 21881 | doi = 10.1073/pnas.96.10.5458 }}</ref><ref name = pmid11818501>{{cite journal | vauthors = Zhou ZX, He B, Hall SH, Wilson EM, French FS | title = Domain interactions between coregulator ARA(70) and the androgen receptor (AR) | journal = Molecular Endocrinology | volume = 16 | issue = 2 | pages = 287–300 | date = Feb 2002 | pmid = 11818501 | doi = 10.1210/mend.16.2.0765 }}</ref><ref name = pmid11779876>{{cite journal | vauthors = He B, Minges JT, Lee LW, Wilson EM | title = The FXXLF motif mediates androgen receptor-specific interactions with coregulators | journal = The Journal of Biological Chemistry | volume = 277 | issue = 12 | pages = 10226–35 | date = Mar 2002 | pmid = 11779876 | doi = 10.1074/jbc.M111975200 }}</ref><ref name = pmid10517667>{{cite journal | vauthors = Gao T, Brantley K, Bolu E, McPhaul MJ | title = RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays | journal = Molecular Endocrinology | volume = 13 | issue = 10 | pages = 1645–56 | date = Oct 1999 | pmid = 10517667 | doi = 10.1210/mend.13.10.0352 }}</ref><ref name = pmid12612084>{{cite journal | vauthors = He B, Wilson EM | title = Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs | journal = Molecular and Cellular Biology | volume = 23 | issue = 6 | pages = 2135–50 | date = Mar 2003 | pmid = 12612084 | pmc = 149467 | doi = 10.1128/mcb.23.6.2135-2150.2003 }}</ref> and
* [[Androgen receptor]],<ref name = pmid8643607 /><ref name = pmid9892017>{{cite journal | vauthors = Alen P, Claessens F, Schoenmakers E, Swinnen JV, Verhoeven G, Rombauts W, Peeters B | title = Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform | journal = Molecular Endocrinology | volume = 13 | issue = 1 | pages = 117–28 | date = January 1999 | pmid = 9892017 | doi = 10.1210/mend.13.1.0214 }}</ref><ref name = pmid9636157>{{cite journal | vauthors = Miyamoto H, Yeh S, Wilding G, Chang C | title = Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 13 | pages = 7379–84 | date = June 1998 | pmid = 9636157 | pmc = 22623 | doi = 10.1073/pnas.95.13.7379 }}</ref><ref name = pmid11404460>{{cite journal | vauthors = Lin HK, Yeh S, Kang HY, Chang C | title = Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 13 | pages = 7200–5 | date = June 2001 | pmid = 11404460 | pmc = 34646 | doi = 10.1073/pnas.121173298 }}</ref><ref name = pmid10318905>{{cite journal | vauthors = Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C | title = From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 10 | pages = 5458–63 | date = May 1999 | pmid = 10318905 | pmc = 21881 | doi = 10.1073/pnas.96.10.5458 }}</ref><ref name = pmid11818501>{{cite journal | vauthors = Zhou ZX, He B, Hall SH, Wilson EM, French FS | title = Domain interactions between coregulator ARA(70) and the androgen receptor (AR) | journal = Molecular Endocrinology | volume = 16 | issue = 2 | pages = 287–300 | date = February 2002 | pmid = 11818501 | doi = 10.1210/mend.16.2.0765 }}</ref><ref name = pmid11779876>{{cite journal | vauthors = He B, Minges JT, Lee LW, Wilson EM | title = The FXXLF motif mediates androgen receptor-specific interactions with coregulators | journal = The Journal of Biological Chemistry | volume = 277 | issue = 12 | pages = 10226–35 | date = March 2002 | pmid = 11779876 | doi = 10.1074/jbc.M111975200 }}</ref><ref name = pmid10517667>{{cite journal | vauthors = Gao T, Brantley K, Bolu E, McPhaul MJ | title = RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays | journal = Molecular Endocrinology | volume = 13 | issue = 10 | pages = 1645–56 | date = October 1999 | pmid = 10517667 | doi = 10.1210/mend.13.10.0352 }}</ref><ref name = pmid12612084>{{cite journal | vauthors = He B, Wilson EM | title = Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs | journal = Molecular and Cellular Biology | volume = 23 | issue = 6 | pages = 2135–50 | date = March 2003 | pmid = 12612084 | pmc = 149467 | doi = 10.1128/mcb.23.6.2135-2150.2003 }}</ref> and
* [[Peroxisome proliferator-activated receptor gamma]]<ref name = pmid10347167>{{cite journal | vauthors = Heinlein CA, Ting HJ, Yeh S, Chang C | title = Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma | journal = The Journal of Biological Chemistry | volume = 274 | issue = 23 | pages = 16147–52 | date = Jun 1999 | pmid = 10347167 | doi = 10.1074/jbc.274.23.16147 }}</ref>
* [[Peroxisome proliferator-activated receptor gamma]]<ref name = pmid10347167>{{cite journal | vauthors = Heinlein CA, Ting HJ, Yeh S, Chang C | title = Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma | journal = The Journal of Biological Chemistry | volume = 274 | issue = 23 | pages = 16147–52 | date = June 1999 | pmid = 10347167 | doi = 10.1074/jbc.274.23.16147 }}</ref>
* [[Ferritin]]<ref>{{cite journal | vauthors = Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC | title = Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy | journal = Nature | volume = 509 | issue = 7498 | pages = 105–9 | date = May 2014 | pmid = 24695223 | pmc = 4180099 | doi = 10.1038/nature13148 | url = https://dash.harvard.edu/bitstream/handle/1/13454816/4180099.pdf?sequence=1 }}</ref><ref>{{cite journal | vauthors = Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G, Cantwell J, Luu C, Cornella-Taracido I, Harrington E, Fekkes P, Lei H, Fang Q, Digan ME, Burdick D, Powers AF, Helliwell SB, D'Aquin S, Bastien J, Wang H, Wiederschain D, Kuerth J, Bergman P, Schwalb D, Thomas J, Ugwonali S, Harbinski F, Tallarico J, Wilson CJ, Myer VE, Porter JA, Bussiere DE, Finan PM, Labow MA, Mao X, Hamann LG, Manning BD, Valdez RA, Nicholson T, Schirle M, Knapp MS, Keaney EP, Murphy LO | display-authors = 6 | title = Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo | journal = Nature Cell Biology | volume = 16 | issue = 11 | pages = 1069–79 | date = November 2014 | pmid = 25327288 | doi = 10.1038/ncb3053  }}</ref>
* [[ATG8]]<ref>{{cite journal | vauthors = Bellelli R, Federico G, Matte' A, Colecchia D, Iolascon A, Chiariello M, Santoro M, De Franceschi L, Carlomagno F | title = NCOA4 Deficiency Impairs Systemic Iron Homeostasis | journal = Cell Reports | volume = 14 | issue = 3 | pages = 411–421 | date = January 2016 | pmid = 26776506 | doi = 10.1016/j.celrep.2015.12.065 }}</ref>


== See also ==
== See also ==
Line 13: Line 15:
== References ==
== References ==
{{reflist}}
{{reflist}}
== External links ==
* {{NURSA|C92}}


== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Minoletti F, Butti MG, Coronelli S, Miozzo M, Sozzi G, Pilotti S, Tunnacliffe A, Pierotti MA, Bongarzone I | title = The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2 | journal = Genes, Chromosomes & Cancer | volume = 11 | issue = 1 | pages = 51–7 | date = Sep 1994 | pmid = 7529046 | doi = 10.1002/gcc.2870110108 }}
* {{cite journal | vauthors = Minoletti F, Butti MG, Coronelli S, Miozzo M, Sozzi G, Pilotti S, Tunnacliffe A, Pierotti MA, Bongarzone I | title = The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2 | journal = Genes, Chromosomes & Cancer | volume = 11 | issue = 1 | pages = 51–7 | date = September 1994 | pmid = 7529046 | doi = 10.1002/gcc.2870110108 }}
* {{cite journal | vauthors = Jhiang SM, Smanik PA, Mazzaferri EL | title = Development of a single-step duplex RT-PCR detecting different forms of ret activation, and identification of the third form of in vivo ret activation in human papillary thyroid carcinoma | journal = Cancer Letters | volume = 78 | issue = 1-3 | pages = 69–76 | date = Apr 1994 | pmid = 8180971 | doi = 10.1016/0304-3835(94)90033-7 }}
* {{cite journal | vauthors = Jhiang SM, Smanik PA, Mazzaferri EL | title = Development of a single-step duplex RT-PCR detecting different forms of ret activation, and identification of the third form of in vivo ret activation in human papillary thyroid carcinoma | journal = Cancer Letters | volume = 78 | issue = 1-3 | pages = 69–76 | date = April 1994 | pmid = 8180971 | doi = 10.1016/0304-3835(94)90033-7 }}
* {{cite journal | vauthors = Bongarzone I, Butti MG, Coronelli S, Borrello MG, Santoro M, Mondellini P, Pilotti S, Fusco A, Della Porta G, Pierotti MA | title = Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas | journal = Cancer Research | volume = 54 | issue = 11 | pages = 2979–85 | date = Jun 1994 | pmid = 8187085 | doi =  }}
* {{cite journal | vauthors = Bongarzone I, Butti MG, Coronelli S, Borrello MG, Santoro M, Mondellini P, Pilotti S, Fusco A, Della Porta G, Pierotti MA | title = Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas | journal = Cancer Research | volume = 54 | issue = 11 | pages = 2979–85 | date = June 1994 | pmid = 8187085 | doi =  }}
* {{cite journal | vauthors = Bongarzone I, Butti MG, Fugazzola L, Pacini F, Pinchera A, Vorontsova TV, Demidchik EP, Pierotti MA | title = Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas | journal = Genomics | volume = 42 | issue = 2 | pages = 252–9 | date = Jun 1997 | pmid = 9192845 | doi = 10.1006/geno.1997.4685 }}
* {{cite journal | vauthors = Bongarzone I, Butti MG, Fugazzola L, Pacini F, Pinchera A, Vorontsova TV, Demidchik EP, Pierotti MA | title = Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas | journal = Genomics | volume = 42 | issue = 2 | pages = 252–9 | date = June 1997 | pmid = 9192845 | doi = 10.1006/geno.1997.4685 }}
* {{cite journal | vauthors = Miyamoto H, Yeh S, Wilding G, Chang C | title = Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 13 | pages = 7379–84 | date = Jun 1998 | pmid = 9636157 | pmc = 22623 | doi = 10.1073/pnas.95.13.7379 }}
* {{cite journal | vauthors = Miyamoto H, Yeh S, Wilding G, Chang C | title = Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 13 | pages = 7379–84 | date = June 1998 | pmid = 9636157 | pmc = 22623 | doi = 10.1073/pnas.95.13.7379 }}
* {{cite journal | vauthors = Alen P, Claessens F, Schoenmakers E, Swinnen JV, Verhoeven G, Rombauts W, Peeters B | title = Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform | journal = Molecular Endocrinology | volume = 13 | issue = 1 | pages = 117–28 | date = Jan 1999 | pmid = 9892017 | doi = 10.1210/mend.13.1.0214 }}
* {{cite journal | vauthors = Alen P, Claessens F, Schoenmakers E, Swinnen JV, Verhoeven G, Rombauts W, Peeters B | title = Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform | journal = Molecular Endocrinology | volume = 13 | issue = 1 | pages = 117–28 | date = January 1999 | pmid = 9892017 | doi = 10.1210/mend.13.1.0214 }}
* {{cite journal | vauthors = Kang HY, Yeh S, Fujimoto N, Chang C | title = Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor | journal = The Journal of Biological Chemistry | volume = 274 | issue = 13 | pages = 8570–6 | date = Mar 1999 | pmid = 10085091 | doi = 10.1074/jbc.274.13.8570 }}
* {{cite journal | vauthors = Kang HY, Yeh S, Fujimoto N, Chang C | title = Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor | journal = The Journal of Biological Chemistry | volume = 274 | issue = 13 | pages = 8570–6 | date = March 1999 | pmid = 10085091 | doi = 10.1074/jbc.274.13.8570 }}
* {{cite journal | vauthors = Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C | title = From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 10 | pages = 5458–63 | date = May 1999 | pmid = 10318905 | pmc = 21881 | doi = 10.1073/pnas.96.10.5458 }}
* {{cite journal | vauthors = Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C | title = From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 10 | pages = 5458–63 | date = May 1999 | pmid = 10318905 | pmc = 21881 | doi = 10.1073/pnas.96.10.5458 }}
* {{cite journal | vauthors = Heinlein CA, Ting HJ, Yeh S, Chang C | title = Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma | journal = The Journal of Biological Chemistry | volume = 274 | issue = 23 | pages = 16147–52 | date = Jun 1999 | pmid = 10347167 | doi = 10.1074/jbc.274.23.16147 }}
* {{cite journal | vauthors = Heinlein CA, Ting HJ, Yeh S, Chang C | title = Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma | journal = The Journal of Biological Chemistry | volume = 274 | issue = 23 | pages = 16147–52 | date = June 1999 | pmid = 10347167 | doi = 10.1074/jbc.274.23.16147 }}
* {{cite journal | vauthors = Gao T, Brantley K, Bolu E, McPhaul MJ | title = RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays | journal = Molecular Endocrinology | volume = 13 | issue = 10 | pages = 1645–56 | date = Oct 1999 | pmid = 10517667 | doi = 10.1210/mend.13.10.0352 }}
* {{cite journal | vauthors = Gao T, Brantley K, Bolu E, McPhaul MJ | title = RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays | journal = Molecular Endocrinology | volume = 13 | issue = 10 | pages = 1645–56 | date = October 1999 | pmid = 10517667 | doi = 10.1210/mend.13.10.0352 }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = November 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | date = September 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | date = Sep 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
* {{cite journal | vauthors = Lin HK, Yeh S, Kang HY, Chang C | title = Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 13 | pages = 7200–5 | date = June 2001 | pmid = 11404460 | pmc = 34646 | doi = 10.1073/pnas.121173298 }}
* {{cite journal | vauthors = Lin HK, Yeh S, Kang HY, Chang C | title = Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 13 | pages = 7200–5 | date = Jun 2001 | pmid = 11404460 | pmc = 34646 | doi = 10.1073/pnas.121173298 }}
* {{cite journal | vauthors = Basolo F, Giannini R, Monaco C, Melillo RM, Carlomagno F, Pancrazi M, Salvatore G, Chiappetta G, Pacini F, Elisei R, Miccoli P, Pinchera A, Fusco A, Santoro M | title = Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma | journal = The American Journal of Pathology | volume = 160 | issue = 1 | pages = 247–54 | date = January 2002 | pmid = 11786418 | pmc = 1867131 | doi = 10.1016/S0002-9440(10)64368-4 }}
* {{cite journal | vauthors = Basolo F, Giannini R, Monaco C, Melillo RM, Carlomagno F, Pancrazi M, Salvatore G, Chiappetta G, Pacini F, Elisei R, Miccoli P, Pinchera A, Fusco A, Santoro M | title = Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma | journal = The American Journal of Pathology | volume = 160 | issue = 1 | pages = 247–54 | date = Jan 2002 | pmid = 11786418 | pmc = 1867131 | doi = 10.1016/S0002-9440(10)64368-4 }}
* {{cite journal | vauthors = Zhou ZX, He B, Hall SH, Wilson EM, French FS | title = Domain interactions between coregulator ARA(70) and the androgen receptor (AR) | journal = Molecular Endocrinology | volume = 16 | issue = 2 | pages = 287–300 | date = February 2002 | pmid = 11818501 | doi = 10.1210/mend.16.2.0765 }}
* {{cite journal | vauthors = Zhou ZX, He B, Hall SH, Wilson EM, French FS | title = Domain interactions between coregulator ARA(70) and the androgen receptor (AR) | journal = Molecular Endocrinology | volume = 16 | issue = 2 | pages = 287–300 | date = Feb 2002 | pmid = 11818501 | doi = 10.1210/mend.16.2.0765 }}
* {{cite journal | vauthors = Thin TH, Kim E, Yeh S, Sampson ER, Chen YT, Collins LL, Basavappa R, Chang C | title = Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 39 | pages = 36499–508 | date = September 2002 | pmid = 12068007 | doi = 10.1074/jbc.M202824200 }}
* {{cite journal | vauthors = Thin TH, Kim E, Yeh S, Sampson ER, Chen YT, Collins LL, Basavappa R, Chang C | title = Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 39 | pages = 36499–508 | date = Sep 2002 | pmid = 12068007 | doi = 10.1074/jbc.M202824200 }}
{{refend}}
{{refend}}


== External links ==
* {{NURSA|C92}}
{{NLM content}}
{{NLM content}}
{{Transcription coregulators}}
{{Transcription coregulators}}

Latest revision as of 13:10, 4 November 2018

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Orthologs
SpeciesHumanMouse
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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

Nuclear receptor coactivator 4 is a protein that in humans is encoded by the NCOA4 gene.[1][2][3] It plays an important role in ferritinophagy, acting as a cargo receptor, binding to the ferritin heavy chain and latching on to ATG8 on the surface of the autophagosome.

Interactions

NCOA4 has been shown to interact with:

See also

References

  1. ↑ Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A (February 1994). "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma". Oncogene. 9 (2): 509–16. PMID 8290261.
  2. ↑ 2.0 2.1 Yeh S, Chang C (May 1996). "Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells". Proceedings of the National Academy of Sciences of the United States of America. 93 (11): 5517–21. doi:10.1073/pnas.93.11.5517. PMC 39278. PMID 8643607.
  3. ↑ "Entrez Gene: NCOA4 Nuclear receptor coactivator 4".
  4. ↑ Alen P, Claessens F, Schoenmakers E, Swinnen JV, Verhoeven G, Rombauts W, Peeters B (January 1999). "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform". Molecular Endocrinology. 13 (1): 117–28. doi:10.1210/mend.13.1.0214. PMID 9892017.
  5. ↑ Miyamoto H, Yeh S, Wilding G, Chang C (June 1998). "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells". Proceedings of the National Academy of Sciences of the United States of America. 95 (13): 7379–84. doi:10.1073/pnas.95.13.7379. PMC 22623. PMID 9636157.
  6. ↑ Lin HK, Yeh S, Kang HY, Chang C (June 2001). "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor". Proceedings of the National Academy of Sciences of the United States of America. 98 (13): 7200–5. doi:10.1073/pnas.121173298. PMC 34646. PMID 11404460.
  7. ↑ Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C (May 1999). "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (10): 5458–63. doi:10.1073/pnas.96.10.5458. PMC 21881. PMID 10318905.
  8. ↑ Zhou ZX, He B, Hall SH, Wilson EM, French FS (February 2002). "Domain interactions between coregulator ARA(70) and the androgen receptor (AR)". Molecular Endocrinology. 16 (2): 287–300. doi:10.1210/mend.16.2.0765. PMID 11818501.
  9. ↑ He B, Minges JT, Lee LW, Wilson EM (March 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". The Journal of Biological Chemistry. 277 (12): 10226–35. doi:10.1074/jbc.M111975200. PMID 11779876.
  10. ↑ Gao T, Brantley K, Bolu E, McPhaul MJ (October 1999). "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays". Molecular Endocrinology. 13 (10): 1645–56. doi:10.1210/mend.13.10.0352. PMID 10517667.
  11. ↑ He B, Wilson EM (March 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Molecular and Cellular Biology. 23 (6): 2135–50. doi:10.1128/mcb.23.6.2135-2150.2003. PMC 149467. PMID 12612084.
  12. ↑ Heinlein CA, Ting HJ, Yeh S, Chang C (June 1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma". The Journal of Biological Chemistry. 274 (23): 16147–52. doi:10.1074/jbc.274.23.16147. PMID 10347167.
  13. ↑ Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC (May 2014). "Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy" (PDF). Nature. 509 (7498): 105–9. doi:10.1038/nature13148. PMC 4180099. PMID 24695223.
  14. ↑ Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, et al. (November 2014). "Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo". Nature Cell Biology. 16 (11): 1069–79. doi:10.1038/ncb3053. PMID 25327288.
  15. ↑ Bellelli R, Federico G, Matte' A, Colecchia D, Iolascon A, Chiariello M, Santoro M, De Franceschi L, Carlomagno F (January 2016). "NCOA4 Deficiency Impairs Systemic Iron Homeostasis". Cell Reports. 14 (3): 411–421. doi:10.1016/j.celrep.2015.12.065. PMID 26776506.

Further reading

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