VIPoma history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
The hallmark of VIPoma is watery [[diarrhea]]. A positive history of [[abdominal pain]], [[weight loss]], [[numbness]], and [[weakness]] is suggestive of VIPoma | The hallmark of VIPoma is watery [[diarrhea]]. A positive history of [[abdominal pain]], [[weight loss]], [[numbness]], and [[weakness]] is suggestive of VIPoma | ||
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Revision as of 16:37, 16 September 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2]Parminder Dhingra, M.D. [3] Homa Najafi, M.D.[4]
Overview
The hallmark of VIPoma is watery diarrhea. A positive history of abdominal pain, weight loss, numbness, and weakness is suggestive of VIPoma
History
Patients with VIPoma may have a positive history of:
Symptoms
Common Symptoms
Symptoms of VIPoma usually arise when tumor reaches certain size. Most tumors are > 2cm and metastatic by the time symptoms arise. Common symptoms may include any of the following:[1][2][3][4]
- Watery diarrhea like cholera
- Volume ranges from 750ml to more than 3 liters.
- Secretory diarrhea persists even on fasting for 48 hours and is odorless.
- The stool appears like dilute tea in color, is blood and mucus free.
- Dehydration (thirst, dry skin, dry mouth, tiredness, headaches, and dizziness)
- Lethargy
- Muscle weakness
- Weight loss
- Numbness caused due to hypokalaemia
- Flushing
Less Common Symptoms
- Crampy abdominal pain
- Nausea
- Vomiting
References
- ↑ VIPoma. U.S. National Library of Medicine. Accessed on October 23, 2015. https://www.nlm.nih.gov/medlineplus/ency/article/000228.htm
- ↑ Remme CA, de Groot GH, Schrijver G (2006). "Diagnosis and treatment of VIPoma in a female patient". Eur J Gastroenterol Hepatol. 18 (1): 93–9. PMID 16357627.
- ↑ Ghaferi AA, Chojnacki KA, Long WD, Cameron JL, Yeo CJ (2008). "Pancreatic VIPomas: subject review and one institutional experience". J Gastrointest Surg. 12 (2): 382–93. doi:10.1007/s11605-007-0177-0. PMID 17510774.
- ↑ Ito T, Igarashi H, Jensen RT (2012). "Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances". Best Pract Res Clin Gastroenterol. 26 (6): 737–53. doi:10.1016/j.bpg.2012.12.003. PMC 3627221. PMID 23582916.