Cryptogenic organizing pneumonia medical therapy: Difference between revisions
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*Corticosteroids are used as first-line treatment for patients with the symptomatic and progressive disease. | *Corticosteroids are used as first-line treatment for patients with the symptomatic and progressive disease. | ||
*For asymptomatic mass lesions or nonprogressive disease, treatment is not required, observation is required till they become symptomatic. | *For asymptomatic mass lesions or nonprogressive disease, treatment is not required, observation is required till they become symptomatic. | ||
Standardized regimens of corticosteroids for the symptomatic and progressive disease are: | |||
*Preferred regimen (1) [[ | *Preferred regimen (1) [[Prednisone]] 0.75 mg/kg PO q24h for 4 weeks | ||
*Followed by ( | **Followed by (2) [[Prednisolone]] 0.5 mg/kg PO q24h for 4 weeks | ||
**Followed by (3) [[Prednisolone]] 20mg PO q24h for 4 weeks | |||
**Followed by (4) [[Prednisolone]] 10mg PO q24h for 6 weeks | |||
**Followed by (4) [[Prednisolone]] 5mg PO q24h for 6 weeks before they were stopped | |||
Severe cases: | |||
*Preferred regimen (1)[[Prednisolone]] 2mg/kg IV q24h for first 3-5 days. | |||
Followed by same regimen discussed above. | |||
'''Relapses:''' | '''Relapses:''' | ||
*Relapses are very common with corticosteroids therapy. | *Relapses are very common with corticosteroids therapy. | ||
| Line 19: | Line 25: | ||
**Increased gamma-glutamyltransferase levels | **Increased gamma-glutamyltransferase levels | ||
**Increased alkaline phosphatase levels | **Increased alkaline phosphatase levels | ||
*Treatment of relapses: | |||
*Relapses occur while receiving prednisone at 20 mg daily; treat with increasing the dose and decreased as discussed above. | |||
==References== | ==References== | ||
Revision as of 22:14, 27 February 2018
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Cryptogenic Organizing Pneumonia Microchapters |
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Differentiating Cryptogenic organizing pneumonia from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Cryptogenic organizing pneumonia medical therapy On the Web |
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American Roentgen Ray Society Images of Cryptogenic organizing pneumonia medical therapy |
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Cryptogenic organizing pneumonia medical therapy in the news |
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Directions to Hospitals Treating Cryptogenic organizing pneumonitis |
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Risk calculators and risk factors for Cryptogenic organizing pneumonia medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
Medical Therapy
- The mainstay of the therapy is pharmacotherapy.
- Corticosteroids are used as first-line treatment for patients with the symptomatic and progressive disease.
- For asymptomatic mass lesions or nonprogressive disease, treatment is not required, observation is required till they become symptomatic.
Standardized regimens of corticosteroids for the symptomatic and progressive disease are:
- Preferred regimen (1) Prednisone 0.75 mg/kg PO q24h for 4 weeks
- Followed by (2) Prednisolone 0.5 mg/kg PO q24h for 4 weeks
- Followed by (3) Prednisolone 20mg PO q24h for 4 weeks
- Followed by (4) Prednisolone 10mg PO q24h for 6 weeks
- Followed by (4) Prednisolone 5mg PO q24h for 6 weeks before they were stopped
Severe cases:
- Preferred regimen (1)Prednisolone 2mg/kg IV q24h for first 3-5 days.
Followed by same regimen discussed above. Relapses:
- Relapses are very common with corticosteroids therapy.
- The predictors of relapses are:
- Delayed treatment
- Increased gamma-glutamyltransferase levels
- Increased alkaline phosphatase levels
- Treatment of relapses:
- Relapses occur while receiving prednisone at 20 mg daily; treat with increasing the dose and decreased as discussed above.