Monoclonal gammopathy of undetermined significance causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2]

Overview

The most common causes of monoclonal gammopathy of undetermined significance classification are genetic mutations in genes like cyclin D1, FGFR-3, MMSET, C-MAF, and MAFB.

Causes

The most common causes of monoclonal gammopathy of undetermined significance classification are genetic mutations. However, there is no established cause of progression of multiple myeloma to monoclonal gammopathy of undetermined significance classification.

Genetic causes

Abnormalities in cytogenes	Affected genes
IgH translocation:
t(11;14), q(13;32)	cyclin D1
t(4;14)(p16;q32)	FGFR-3, and MMSET
t(14;16)(q32;q23)	C-MAF
t(6;14)(q32;q11)	MAFB
IgH non-translocated :
Hyper diploid	Numerous