Monoclonal gammopathy of undetermined significance laboratory findings: Difference between revisions
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{{ Monoclonal gammopathy of undetermined significance }} | {{Monoclonal gammopathy of undetermined significance }} | ||
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==Overview== | ==Overview== | ||
Patients may be diagnosed with MGUS if they fulfill the three component criteria which includes a monoclonal paraprotein band less than 3 g/dl, plasma cells less than 10% on bone marrow examination, and no evidence of bone lesions, [[anemia]], [[hypercalcemia]], or [[renal insufficiency]] related to the [[paraprotein]]. Check the blood for [[hypercalcemia]] and deterioration in [[renal function]], check the [[urine]] for [[Bence Jones protein|Bence-Jones protein]]. | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
Patients may be diagnosed with MGUS if they fulfill the following three criteria:<ref>{{cite journal | author =International Myeloma Working Group | title = Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. | journal = Br J Haematol | volume = 121 | issue = 5 | pages = 749-57 | year = 2003 | id = PMID 12780789}}</ref> | Patients may be diagnosed with MGUS if they fulfill the following three criteria:<ref>{{cite journal | author =International Myeloma Working Group | title = Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. | journal = Br J Haematol | volume = 121 | issue = 5 | pages = 749-57 | year = 2003 | id = PMID 12780789}}</ref> | ||
#A monoclonal paraprotein band less than 3 g/dl; | #A monoclonal [[paraprotein]] band less than 3 g/dl; | ||
#[[Plasma cell]]s less than 10% on [[bone marrow examination]]; and | #[[Plasma cell]]s less than 10% on [[bone marrow examination]]; and | ||
#No evidence of bone lesions, [[anemia]], [[hypercalcemia]], or [[renal insufficiency]] related to the paraprotein. | #No evidence of bone lesions, [[anemia]], [[hypercalcemia]], or [[renal insufficiency]] related to the [[paraprotein]]. | ||
Check the blood for [[hypercalcemia]] and deterioration in [[renal function]], check the urine for [[Bence-Jones]] protein | Check the blood for [[hypercalcemia]] and deterioration in [[renal function]], check the urine for [[Bence-Jones]] protein | ||
Revision as of 13:57, 14 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2]
Overview
Patients may be diagnosed with MGUS if they fulfill the three component criteria which includes a monoclonal paraprotein band less than 3 g/dl, plasma cells less than 10% on bone marrow examination, and no evidence of bone lesions, anemia, hypercalcemia, or renal insufficiency related to the paraprotein. Check the blood for hypercalcemia and deterioration in renal function, check the urine for Bence-Jones protein.
Laboratory Findings
Patients may be diagnosed with MGUS if they fulfill the following three criteria:[1]
- A monoclonal paraprotein band less than 3 g/dl;
- Plasma cells less than 10% on bone marrow examination; and
- No evidence of bone lesions, anemia, hypercalcemia, or renal insufficiency related to the paraprotein.
Check the blood for hypercalcemia and deterioration in renal function, check the urine for Bence-Jones protein
References
- ↑ International Myeloma Working Group (2003). "Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group". Br J Haematol. 121 (5): 749–57. PMID 12780789.