Aplastic anemia laboratory findings: Difference between revisions
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==Definitive Diagnosis== | ==Definitive Diagnosis== | ||
===Bone Marrow Aspiration and Biopsy=== | ===Bone Marrow Aspiration and Biopsy=== | ||
* | * Hypocellular bone marrow with increased [[adipose tissue]] and decreased [[Hematopoietic cell|hematopoietic cells]] in the marrow space | ||
* [[Bone marrow biopsy]] shows normal maturation of all [[cell]] lines. | |||
* [[Bone marrow biopsy]] | |||
==References== | ==References== |
Revision as of 16:40, 21 August 2018
Aplastic anemia Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2] Nazia Fuad M.D.
Overview
Patients with aplastic anemia have a hypoplastic bone marrow (<20% cellularity), pancytopenia (transfusion-dependent anemia, thrombocytopenia, and severe neutropenia), a low reticulocyte count, and a normal maturation of all cell lines.
Laboratory Findings
Laboratory findings consistent with the diagnosis of aplastic anemia include:[1]
Complete Blood Count (CBC)
- Decreased hemoglobin
- Decreased hematocrit
- Pancytopenia (anemia, thrombocytopenia, and severe neutropenia)
Reticulocyte Count
Peripheral blood smear
- Macrocytosis
- Poikilocytosis
- Small size platelets
Other tests
The following tests should be performed to rule out other conditions:
- Renal function
- Basic metabolic panel
- Liver enzymes
- Thyroid function tests
- Viral studies
- Vitamin B12 and folic acid levels.
Definitive Diagnosis
Bone Marrow Aspiration and Biopsy
- Hypocellular bone marrow with increased adipose tissue and decreased hematopoietic cells in the marrow space
- Bone marrow biopsy shows normal maturation of all cell lines.
References
- ↑ . doi:10.1111/j.1365. Missing or empty
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