Mast cell leukemia classification: Difference between revisions
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#[[Skin|Cutaneous]] [[mastocytosis]] (CM) | #[[Skin|Cutaneous]] [[mastocytosis]] (CM) | ||
#[[Systemic]] [[mastocytosis]] | #[[Systemic]] [[mastocytosis]] | ||
::*Indolent systemic mastocytosis (ISM) | |||
::*Smoldering systemic mastocytosis (SSM) | |||
::*Systemic mastocytosis with an associated hematological neoplasm (SM-AHN) | |||
::*Aggressive systemic mastocytosis (ASM) | |||
::*Mast cell leukaemia (MCL) | |||
#Mast cell sarcoma (MCS) | #Mast cell sarcoma (MCS) | ||
Revision as of 15:39, 19 October 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
Mast cell leukemia may be classified into two categories based on prognosis (leukemic and aleukemic).[1] Based on the duration of symptoms, mast cell leukemia may be classified into either acute or chronic.[2]
Classification
- In 2016 the World Health Organization (WHO) changed classification of tumors of hematopoietic and lymphoid tissues.[3]
- In the current classification mastocytosis is a major category. In the last classification mastocytosis was subtype of major category (myeloproliferative neoplasms).[3]
- Indolent systemic mastocytosis (ISM)
- Smoldering systemic mastocytosis (SSM)
- Systemic mastocytosis with an associated hematological neoplasm (SM-AHN)
- Aggressive systemic mastocytosis (ASM)
- Mast cell leukaemia (MCL)
- Mast cell sarcoma (MCS)
- Mast cell leukemia may be classified into two categories based on prognosis:[1]
- Leukemic variant
- Circulating mast cells ≥ 10%
- Bone marrow mast cells ≥ 20%
- Aleukemic variant
- Circulating mast cells < 10%
- Based on the duration of symptoms, mast cell leukemia may be classified into:[2]
- Acute mast cell leukemia
- Chronic mast cell leukemia
References
- ↑ 1.0 1.1 Georgin-Lavialle, S.; Lhermitte, L.; Dubreuil, P.; Chandesris, M.-O.; Hermine, O.; Damaj, G. (2012). "Mast cell leukemia". Blood. 121 (8): 1285–1295. doi:10.1182/blood-2012-07-442400. ISSN 0006-4971.
- ↑ 2.0 2.1 Savini, P.; Rondoni, M.; Poletti, G.; Lanzi, A.; Quercia, O.; Soverini, S.; De Benedittis, C.; Musardo, G.; Martinelli, G.; Stefanini, G. F. (2015). "Serum Total Tryptase Level Confirms Itself as a More Reliable Marker of Mast Cells Burden in Mast Cell Leukaemia (Aleukaemic Variant)". Case Reports in Hematology. 2015: 1–4. doi:10.1155/2015/737302. ISSN 2090-6560.
- ↑ 3.0 3.1 Arber, D. A.; Orazi, A.; Hasserjian, R.; Thiele, J.; Borowitz, M. J.; Le Beau, M. M.; Bloomfield, C. D.; Cazzola, M.; Vardiman, J. W. (2016). "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood. 127 (20): 2391–2405. doi:10.1182/blood-2016-03-643544. ISSN 0006-4971.