Mast cell leukemia classification: Difference between revisions
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::*[[Smoldering systemic mastocytosis]] (SSM) | ::*[[Smoldering systemic mastocytosis]] (SSM) | ||
::*[[Systemic]] [[mastocytosis]] with an associated [[hematological]] [[neoplasm]] (SM-AHN) | ::*[[Systemic]] [[mastocytosis]] with an associated [[hematological]] [[neoplasm]] (SM-AHN) | ||
::*Aggressive systemic mastocytosis (ASM) | ::*Aggressive [[systemic]] [[Mast cell tumor|mastocytosis]] (ASM) | ||
::*Mast cell leukaemia (MCL) | ::*Mast cell leukaemia (MCL) | ||
#[[Mast cell]] [[sarcoma]] (MCS) | #[[Mast cell]] [[sarcoma]] (MCS) | ||
*Mast cell leukemia may be classified into two categories based on prognosis:<ref name="Georgin-LavialleLhermitte2012" /> | *Mast cell leukemia may be classified into two categories based on [[prognosis]]:<ref name="Georgin-LavialleLhermitte2012" /> | ||
:*Leukemic variant | :*[[Leukemic]] variant | ||
::*Circulating mast cells ≥ 10% | ::*Circulating [[Mast cell|mast cells]] ≥ 10% | ||
::*Bone marrow mast cells ≥ 20% | ::*[[Bone marrow]] [[Mast cell|mast cells]] ≥ 20% | ||
:*Aleukemic variant | :*[[Aleukemic leukemia|Aleukemic]] variant | ||
::*Circulating mast cells < 10% | ::*Circulating [[Mast cell|mast cells]] < 10% | ||
*Based on the duration of symptoms, mast cell leukemia may be classified into:<ref name="SaviniRondoni2015">{{cite journal|last1=Savini|first1=P.|last2=Rondoni|first2=M.|last3=Poletti|first3=G.|last4=Lanzi|first4=A.|last5=Quercia|first5=O.|last6=Soverini|first6=S.|last7=De Benedittis|first7=C.|last8=Musardo|first8=G.|last9=Martinelli|first9=G.|last10=Stefanini|first10=G. F.|title=Serum Total Tryptase Level Confirms Itself as a More Reliable Marker of Mast Cells Burden in Mast Cell Leukaemia (Aleukaemic Variant)|journal=Case Reports in Hematology|volume=2015|year=2015|pages=1–4|issn=2090-6560|doi=10.1155/2015/737302}}</ref> | *Based on the duration of [[Symptom|symptoms]], mast cell leukemia may be classified into:<ref name="SaviniRondoni2015">{{cite journal|last1=Savini|first1=P.|last2=Rondoni|first2=M.|last3=Poletti|first3=G.|last4=Lanzi|first4=A.|last5=Quercia|first5=O.|last6=Soverini|first6=S.|last7=De Benedittis|first7=C.|last8=Musardo|first8=G.|last9=Martinelli|first9=G.|last10=Stefanini|first10=G. F.|title=Serum Total Tryptase Level Confirms Itself as a More Reliable Marker of Mast Cells Burden in Mast Cell Leukaemia (Aleukaemic Variant)|journal=Case Reports in Hematology|volume=2015|year=2015|pages=1–4|issn=2090-6560|doi=10.1155/2015/737302}}</ref> | ||
:* Acute mast cell leukemia | :* [[Acute (medicine)|Acute]] mast cell leukemia | ||
:* Chronic mast cell leukemia | :* [[Chronic (medical)|Chronic]] mast cell leukemia | ||
==References== | ==References== | ||
Revision as of 13:04, 22 October 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
Mast cell leukemia may be classified into two categories based on prognosis(leukemic and aleukemic).[1] Based on the duration of symptoms, mast cell leukemia may be classified into either acute or chronic.[2]
Classification
- In 2016 the World Health Organization (WHO) changed classification of tumors of hematopoietic and lymphoid tissues.[3]
- In the current classification mastocytosis is a major category. In the last classification mastocytosis was subtype of major category (myeloproliferative neoplasms).[3]
- Indolent systemic mastocytosis (ISM)
- Smoldering systemic mastocytosis (SSM)
- Systemic mastocytosis with an associated hematological neoplasm (SM-AHN)
- Aggressive systemic mastocytosis (ASM)
- Mast cell leukaemia (MCL)
- Leukemic variant
- Circulating mast cells ≥ 10%
- Bone marrow mast cells ≥ 20%
- Aleukemic variant
- Circulating mast cells < 10%
References
- ↑ 1.0 1.1 Georgin-Lavialle, S.; Lhermitte, L.; Dubreuil, P.; Chandesris, M.-O.; Hermine, O.; Damaj, G. (2012). "Mast cell leukemia". Blood. 121 (8): 1285–1295. doi:10.1182/blood-2012-07-442400. ISSN 0006-4971.
- ↑ 2.0 2.1 Savini, P.; Rondoni, M.; Poletti, G.; Lanzi, A.; Quercia, O.; Soverini, S.; De Benedittis, C.; Musardo, G.; Martinelli, G.; Stefanini, G. F. (2015). "Serum Total Tryptase Level Confirms Itself as a More Reliable Marker of Mast Cells Burden in Mast Cell Leukaemia (Aleukaemic Variant)". Case Reports in Hematology. 2015: 1–4. doi:10.1155/2015/737302. ISSN 2090-6560.
- ↑ 3.0 3.1 Arber, D. A.; Orazi, A.; Hasserjian, R.; Thiele, J.; Borowitz, M. J.; Le Beau, M. M.; Bloomfield, C. D.; Cazzola, M.; Vardiman, J. W. (2016). "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood. 127 (20): 2391–2405. doi:10.1182/blood-2016-03-643544. ISSN 0006-4971.