Paget's disease of the breast differential diagnosis: Difference between revisions
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* [[Pityriasis alba]] | * [[Pityriasis alba]] | ||
* [[Ichthyosis]] | * [[Ichthyosis]] | ||
* Infra-auricular and retro-auricular fissuring | * Infra-auricular and retro-auricular fissuring | ||
* Nipple [[eczema]] | * Nipple [[eczema]] | ||
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* Epidermal psoriasiform [[hyperplasia]] | * Epidermal psoriasiform [[hyperplasia]] | ||
* Marked intercellular [[edema]] with spongiotic vesiculation | * Marked intercellular [[edema]] with spongiotic vesiculation | ||
* [[Hyperkeratosis]] | * [[Hyperkeratosis]] | ||
* Psoriasiform [[hyperplasia]] | * Psoriasiform [[hyperplasia]] | ||
* Dyskeratosis | * Dyskeratosis | ||
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* Ill-defined area with hyperechogenicity with inflamed fat lobules | * Ill-defined area with hyperechogenicity with inflamed fat lobules | ||
* Skin thickening | * Skin thickening | ||
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! style="background: #DCDCDC; padding: 5px; text-align: center;" |Inflammatory Breast Cancer | ! style="background: #DCDCDC; padding: 5px; text-align: center;" |Inflammatory Breast Cancer | ||
Revision as of 16:55, 21 February 2019
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Paget's disease of the breast Microchapters |
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Differentiating Paget's disease of the breast from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Paget's disease of the breast differential diagnosis On the Web |
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American Roentgen Ray Society Images of Paget's disease of the breast differential diagnosis |
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Paget's disease of the breast differential diagnosis in the news |
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Blogs on Paget's disease of the breast differential diagnosis |
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Directions to Hospitals Treating Paget's disease of the breast |
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Risk calculators and risk factors for Paget's disease of the breast differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]
Overview
Paget's disease of the breast must be differentiated from atopic dermatitis, eczema, psoriasis, malignant melanoma, Bowen's disease, basal cell carcinoma, and pagetoid dyskeratosis.[1][2]
Differential Diagnosis
Paget’s disease of the breast must be differentiated from other benign and malignant processes of nipple-areola complex such as:[1][2]
- Atopic dermatitis
- Chronic contact dermatitis
- Lactiferous duct ectasia
- Chronic eczema
- Psoriasis
- Nipple duct adenoma
- Malignant melanoma
- Bowen’s disease
- Superficial basal cell carcinoma
- Pagetoid basal cell carcinoma
- Benign intraductal papilloma
- Pagetoid dyskeratosis
| Category | Diseases | Benign or Malignant | Etiology | Clinical manifestations | Para-clinical findings | Gold Standard | Associated factors | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Symptoms | Physical examination | ||||||||||||||||
| Lab Findings | Histopathology | ||||||||||||||||
| Rash | Nipple Discharge | Erythema | Single/
Multiple |
Involved areas | Mastalgia | Breast Exam | Other | Serum IgE | |||||||||
| Eczema | Scalp, face, trunk, postauricular, diaper area and axilla | + | – | + |
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Nl |
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Risk factors include
Generalized seborrheic erythroderma in immunodeficient patients |
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| Skin disorders | Atopic dermatitis | Benign |
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– | Multiple | + |
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– |
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↑ |
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| Allergic contact dermatitis[3] | Benign |
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Erythematous well-demarcated papules | – | May be multiple after 1-2 days of exposure | + | Surrounding the area in contact with the offending agent | + |
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Nl |
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| Psoriasis | Benign |
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Well-circumscribed, pink papules and symmetrically distributed cutaneous plaques with silvery scales | + | Multiple | + |
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+ |
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Nl |
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Risk factors include
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| Malignant melanoma | |||||||||||||||||
| Bowen’s disease | |||||||||||||||||
| Superficial basal cell carcinoma | |||||||||||||||||
| Pagetoid basal cell carcinoma | |||||||||||||||||
| Benign intraductal papilloma | |||||||||||||||||
| Pagetoid dyskeratosis | |||||||||||||||||
| Lactiferous duct ectasia | Benign | * Common among perimenopausalwomen
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* Distention of subareolar ducts | Ultrasound:
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| Nipple duct adenoma | |||||||||||||||||
| Benign Toker cell hyperplasia | |||||||||||||||||
| Breast abscess | Benign | + |
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| Mondors disease | |||||||||||||||||
| Mastitis |
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+ | ± |
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| Inflammatory Breast Cancer | |||||||||||||||||
References
- ↑ 1.0 1.1 Gaspari, Eleonora; Ricci, Aurora; Liberto, Valeria; Scarano, Angela Lia; Fornari, Maria; Simonetti, Giovanni (2013). "An Unusual Case of Mammary Paget's Disease Diagnosed Using Dynamic Contrast-Enhanced MRI". Case Reports in Radiology. 2013: 1–5. doi:10.1155/2013/206235. ISSN 2090-6862.
- ↑ 2.0 2.1 Lopes Filho, Lauro Lourival; Lopes, Ione Maria Ribeiro Soares; Lopes, Lauro Rodolpho Soares; Enokihara, Milvia M. S. S.; Michalany, Alexandre Osores; Matsunaga, Nobuo (2015). "Mammary and extramammary Paget's disease". Anais Brasileiros de Dermatologia. 90 (2): 225–231. doi:10.1590/abd1806-4841.20153189. ISSN 1806-4841.
- ↑ Nosbaum A, Vocanson M, Rozieres A, Hennino A, Nicolas JF (2009). "Allergic and irritant contact dermatitis". Eur J Dermatol. 19 (4): 325–32. doi:10.1684/ejd.2009.0686. PMID 19447733.