Subdural hematoma pathophysiology: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 27: | Line 27: | ||
== Genetics == | == Genetics == | ||
Genes involved in the pathogenesis of subdural hematoma include: | |||
*ADPKD<ref name="McGovernLippa2013">{{cite journal|last1=McGovern|first1=Margaret M.|last2=Lippa|first2=Natalie|last3=Bagiella|first3=Emilia|last4=Schuchman|first4=Edward H.|last5=Desnick|first5=Robert J.|last6=Wasserstein|first6=Melissa P.|title=Morbidity and mortality in type B Niemann–Pick disease|journal=Genetics in Medicine|volume=15|issue=8|year=2013|pages=618–623|issn=1098-3600|doi=10.1038/gim.2013.4}}</ref><ref name="Pirson2010">{{cite journal|last1=Pirson|first1=Yves|title=Extrarenal Manifestations of Autosomal Dominant Polycystic Kidney Disease|journal=Advances in Chronic Kidney Disease|volume=17|issue=2|year=2010|pages=173–180|issn=15485595|doi=10.1053/j.ackd.2010.01.003}}</ref><ref name="MitsiasLevine1996">{{cite journal|last1=Mitsias|first1=Panyiotis|last2=Levine|first2=Steven R.|title=Cerebrovascular complications of Fabry's disease|journal=Annals of Neurology|volume=40|issue=1|year=1996|pages=8–17|issn=0364-5134|doi=10.1002/ana.410400105}}</ref><ref name="GroningerSchaper2005">{{cite journal|last1=Groninger|first1=Anja|last2=Schaper|first2=Jörg|last3=Messing-Juenger|first3=Martina|last4=Mayatepek|first4=Ertan|last5=Rosenbaum|first5=Thorsten|title=Subdural hematoma as clinical presentation of osteogenesis imperfecta|journal=Pediatric Neurology|volume=32|issue=2|year=2005|pages=140–142|issn=08878994|doi=10.1016/j.pediatrneurol.2004.07.011}}</ref><ref name="pmid16735769">{{cite journal |vauthors=Aydin M, Akarsu S, Kabakus N, Akpolat N |title=Mucopolysaccharidosis IIIB, cerebral vasculopathy and recurrent subdural hematoma |journal=Indian Pediatr |volume=43 |issue=5 |pages=437–40 |date=May 2006 |pmid=16735769 |doi= |url=}}</ref> | |||
*Osteogenesis imperfecta | |||
*Fabry's disease | |||
Genes involved in the pathogenesis of | *Mucopolysaccharidosis IIIB | ||
* | *Type B Niemann–Pick disease | ||
* | |||
* | |||
* | |||
== Associated Conditions == | == Associated Conditions == | ||
Conditions associated with [disease name] include: | Conditions associated with [disease name] include: | ||
Revision as of 14:44, 29 May 2019
|
Subdural Hematoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Subdural hematoma pathophysiology On the Web |
|
American Roentgen Ray Society Images of Subdural hematoma pathophysiology |
|
Risk calculators and risk factors for Subdural hematoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Physiology
The normal physiology of bridging veins can be understood as follows:[1]
- In embryonic period, there is lots of anastomosis between brain and dura matter venous drainage.
- After 12 weeks of gestation these anastomosis will disappear and what is left from them create bridging veins.
- These vein s will drain venous blood from underlying brain tissue to the dural sinuses.
Pathogenesis
- It is understood that subdural hematoma is the result of:
- Rupture in bridging veins (mostly due to head trauma) and hemorrhage between dura matter and arachnoid, leading to subdural hematoma.
- Rupture of small cortical atreries and hemorrhage into the space between dura matter and arachnoid, leading to subdural hematoma.
- Intracranial hypotension (mostly due to lumbar punctue) and traction of bridging veins which leads to subdural hematoma
- Subdural hematomas as a result of arterial rupture accounts for 20% of SDH cases and are mostly in temporoparietal region.
- Since most of the SDH cases are due to vein rupture, the bleeding will stop on its own as a result of a clot formation or increased intracranial pressure.
Genetics
Genes involved in the pathogenesis of subdural hematoma include:
- ADPKD[2][3][4][5][6]
- Osteogenesis imperfecta
- Fabry's disease
- Mucopolysaccharidosis IIIB
- Type B Niemann–Pick disease
Associated Conditions
Conditions associated with [disease name] include:
- [Condition 1]
- [Condition 2]
- [Condition 3]
Gross Pathology
On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
References
- ↑ Famaey, Nele; Ying Cui, Zhao; Umuhire Musigazi, Grace; Ivens, Jan; Depreitere, Bart; Verbeken, Erik; Vander Sloten, Jos (2015). "Structural and mechanical characterisation of bridging veins: A review". Journal of the Mechanical Behavior of Biomedical Materials. 41: 222–240. doi:10.1016/j.jmbbm.2014.06.009. ISSN 1751-6161.
- ↑ McGovern, Margaret M.; Lippa, Natalie; Bagiella, Emilia; Schuchman, Edward H.; Desnick, Robert J.; Wasserstein, Melissa P. (2013). "Morbidity and mortality in type B Niemann–Pick disease". Genetics in Medicine. 15 (8): 618–623. doi:10.1038/gim.2013.4. ISSN 1098-3600.
- ↑ Pirson, Yves (2010). "Extrarenal Manifestations of Autosomal Dominant Polycystic Kidney Disease". Advances in Chronic Kidney Disease. 17 (2): 173–180. doi:10.1053/j.ackd.2010.01.003. ISSN 1548-5595.
- ↑ Mitsias, Panyiotis; Levine, Steven R. (1996). "Cerebrovascular complications of Fabry's disease". Annals of Neurology. 40 (1): 8–17. doi:10.1002/ana.410400105. ISSN 0364-5134.
- ↑ Groninger, Anja; Schaper, Jörg; Messing-Juenger, Martina; Mayatepek, Ertan; Rosenbaum, Thorsten (2005). "Subdural hematoma as clinical presentation of osteogenesis imperfecta". Pediatric Neurology. 32 (2): 140–142. doi:10.1016/j.pediatrneurol.2004.07.011. ISSN 0887-8994.
- ↑ Aydin M, Akarsu S, Kabakus N, Akpolat N (May 2006). "Mucopolysaccharidosis IIIB, cerebral vasculopathy and recurrent subdural hematoma". Indian Pediatr. 43 (5): 437–40. PMID 16735769.