VIPoma laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
Laboratory findings consistent with the diagnosis of VIPoma include: | Laboratory findings consistent with the diagnosis of VIPoma include:<ref name="pmid23582916">{{cite journal| author=Ito T, Igarashi H, Jensen RT| title=Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances. | journal=Best Pract Res Clin Gastroenterol | year= 2012 | volume= 26 | issue= 6 | pages= 737-53 | pmid=23582916 | doi=10.1016/j.bpg.2012.12.003 | pmc=3627221 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23582916 }}</ref><ref name="pmid27583474">{{cite journal| author=Nilubol N, Freedman EM, Quezado MM, Patel D, Kebebew E| title=Pancreatic Neuroendocrine Tumor Secreting Vasoactive Intestinal Peptide and Dopamine With Pulmonary Emboli: A Case Report. | journal=J Clin Endocrinol Metab | year= 2016 | volume= 101 | issue= 10 | pages= 3564-3567 | pmid=27583474 | doi=10.1210/jc.2016-2051 | pmc=5052354 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27583474 }}</ref> | ||
*Elevated serum vasoactive intestinal polypeptide (VIP) levels: | *Elevated serum vasoactive intestinal polypeptide (VIP) levels: | ||
**Normal fasting serum [[Vasoactive intestinal peptide|VIP]] level is generally < 75pg/ml | **Normal fasting serum [[Vasoactive intestinal peptide|VIP]] level is generally < 75pg/ml | ||
**In VIPomas levels of [[Vasoactive intestinal peptide|VIP]] is generally > 500pg/ml. | **In VIPomas levels of [[Vasoactive intestinal peptide|VIP]] is generally > 500pg/ml. | ||
**VIP level > 200pg/ml is strongly suggestive of VIPoma. | **VIP level > 200pg/ml is strongly suggestive of VIPoma. | ||
**[[Hormone]] measurement taken at the time of [[diarrhea]]<nowiki/>l episode has the highest yield as VIP secretion during period of [[diarrhea]] and has short t1/2 (approx. 2 mins in blood). | **[[Hormone]] measurement taken at the time of [[diarrhea]]<nowiki/>l episode has the highest yield as VIP secretion during period of [[diarrhea]] and has short t1/2 (approx. 2 mins in blood). | ||
**Single measurement should be confirmed by repeat testing. | **Single measurement should be confirmed by repeat testing. | ||
*Elevated pancreatic [[polypeptide]] levels (Normal < 312pg/ml) | *Elevated pancreatic [[polypeptide]] levels (Normal < 312pg/ml) and [[neurotensin]] levels. | ||
*Low serum [[potassium]], [[bicarbonate]], and [[magnesium]] levels secondary to fecal loss. | *Low serum [[potassium]], [[bicarbonate]], and [[magnesium]] levels secondary to fecal loss. | ||
*[[Hypercalcaemia|High calcium]] levels secondary to fecal loss. | *[[Hypercalcaemia|High calcium]] levels secondary to fecal loss. | ||
Revision as of 22:56, 3 October 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2] Homa Najafi, M.D.[3]
Overview
Laboratory tests used in the diagnosis of VIPoma include serum vasoactive intestinal polypeptide (VIP) levels, basal gastric acid output, and CMP for potassium, bicarbonate, magnesium, and calcium levels.
Laboratory Findings
Laboratory findings consistent with the diagnosis of VIPoma include:[1][2]
- Elevated serum vasoactive intestinal polypeptide (VIP) levels:
- Normal fasting serum VIP level is generally < 75pg/ml
- In VIPomas levels of VIP is generally > 500pg/ml.
- VIP level > 200pg/ml is strongly suggestive of VIPoma.
- Hormone measurement taken at the time of diarrheal episode has the highest yield as VIP secretion during period of diarrhea and has short t1/2 (approx. 2 mins in blood).
- Single measurement should be confirmed by repeat testing.
- Elevated pancreatic polypeptide levels (Normal < 312pg/ml) and neurotensin levels.
- Low serum potassium, bicarbonate, and magnesium levels secondary to fecal loss.
- High calcium levels secondary to fecal loss.
- Low basal gastric acid output.
References
- ↑ Ito T, Igarashi H, Jensen RT (2012). "Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances". Best Pract Res Clin Gastroenterol. 26 (6): 737–53. doi:10.1016/j.bpg.2012.12.003. PMC 3627221. PMID 23582916.
- ↑ Nilubol N, Freedman EM, Quezado MM, Patel D, Kebebew E (2016). "Pancreatic Neuroendocrine Tumor Secreting Vasoactive Intestinal Peptide and Dopamine With Pulmonary Emboli: A Case Report". J Clin Endocrinol Metab. 101 (10): 3564–3567. doi:10.1210/jc.2016-2051. PMC 5052354. PMID 27583474.