Microangiopathic hemolytic anemia laboratory findings: Difference between revisions
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* Raised mean [[platelet]] volume | * Raised mean [[platelet]] volume | ||
===Peripheral Blood Smear=== | ===Peripheral Blood Smear=== | ||
* As [[red blood cell]]s travel through these damaged vessels, they are shredded. The result is red cell fragmentation and intravascular [[hemolysis]]. Under the microscope, damaged red cells have the appearance of [[schistocyte]]s. | * [[Red cell]] polychromasia, anisocytosis, and normochromic appearance with a lack of central [[pallor]]. | ||
* As [[red blood cell]]s travel through these damaged vessels, they are shredded. The result is [[red cell] fragmentation and intravascular [[hemolysis]]. Under the microscope, damaged red cells have the appearance of [[schistocyte]]s. It includes helmet [[cell]]s, irregular projections, and crescent-shape. | |||
* [[Automated analyser]]s (the machines that perform routine [[full blood count]]s in most hospitals) are generally programmed to flag blood films that display red blood cell fragments or ''schistocytes''. | * [[Automated analyser]]s (the machines that perform routine [[full blood count]]s in most hospitals) are generally programmed to flag blood films that display red blood cell fragments or ''schistocytes''. | ||
Revision as of 19:52, 21 January 2021
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Microangiopathic hemolytic anemia Microchapters |
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Differentiating Microangiopathic hemolytic anemia from other Diseases |
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Diagnosis |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
Blood Tests
Laboratory findings consistent with the diagnosis of microangiopathic hemolytic anemia include[1]:
Complete Blood Count
- Normochromic normocytic anemia
- Thrombocytopenia usually significant with platelet count less than 20,000/μL.
- High reticulocyte count
- Raised red ce distribution width
- Raised mean platelet volume
Peripheral Blood Smear
- Red cell polychromasia, anisocytosis, and normochromic appearance with a lack of central pallor.
- As red blood cells travel through these damaged vessels, they are shredded. The result is [[red cell] fragmentation and intravascular hemolysis. Under the microscope, damaged red cells have the appearance of schistocytes. It includes helmet cells, irregular projections, and crescent-shape.
- Automated analysers (the machines that perform routine full blood counts in most hospitals) are generally programmed to flag blood films that display red blood cell fragments or schistocytes.
References
- ↑ Kottke-Marchant K (2017). "Diagnostic approach to microangiopathic hemolytic disorders". Int J Lab Hematol. 39 Suppl 1: 69–75. doi:10.1111/ijlh.12671. PMID 28447417.