Fever of unknown origin differential diagnosis: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
|||
| Line 11: | Line 11: | ||
==Overview== | ==Overview== | ||
#Fever can be the presenting symptom with many diseases, it is therefore important to differentiate fever of unknown origin from all those diseases which present with fever. | #[[Fever]] can be the presenting symptom with many diseases, it is therefore important to differentiate fever of unknown origin from all those diseases which present with fever. | ||
#Because of the broad range of differential diagnosis they can be grouped into four categories based on their etiology. | #Because of the broad range of differential diagnosis they can be grouped into four categories based on their etiology. | ||
*Infectious | *Infectious | ||
*Malignant | *[[Malignant]] | ||
*Inflammatory | *[[Inflammatory]] | ||
*Miscellaneous<ref name="CunhaLortholary2015">{{cite journal|last1=Cunha|first1=Burke A.|last2=Lortholary|first2=Olivier|last3=Cunha|first3=Cheston B.|title=Fever of Unknown Origin: A Clinical Approach|journal=The American Journal of Medicine|volume=128|issue=10|year=2015|pages=1138.e1–1138.e15|issn=00029343|doi=10.1016/j.amjmed.2015.06.001}}</ref> | *Miscellaneous<ref name="CunhaLortholary2015">{{cite journal|last1=Cunha|first1=Burke A.|last2=Lortholary|first2=Olivier|last3=Cunha|first3=Cheston B.|title=Fever of Unknown Origin: A Clinical Approach|journal=The American Journal of Medicine|volume=128|issue=10|year=2015|pages=1138.e1–1138.e15|issn=00029343|doi=10.1016/j.amjmed.2015.06.001}}</ref> | ||
| Line 26: | Line 26: | ||
Examples include: | Examples include: | ||
*Lyme disease | *[[Lyme disease]] | ||
*Histoplasmosis | *[[Histoplasmosis]] | ||
*Q fever | *[[Q fever]] | ||
*Brucellosis | *[[Brucellosis]] | ||
*Toxoplasmosis | *[[Toxoplasmosis]] | ||
*Leptospirosis | *[[Leptospirosis]] | ||
*Ehrlichiosis | *[[Ehrlichiosis]] | ||
*Anaplasmosis | *[[Anaplasmosis]] | ||
*Tuberculosis | *[[Tuberculosis]] | ||
*Infectious mononucleosis | *[[Infectious mononucleosis]] | ||
*mycobacterium avium infection etc. | *[[Mycobacterium avium complex infection|mycobacterium avium]] infection etc. | ||
===Malignant=== | ===Malignant=== | ||
| Line 43: | Line 43: | ||
Examples include: | Examples include: | ||
*Hodgkin lymphoma | *[[Hodgkin lymphoma]] | ||
*myeloproliferative disorders | *[[Myeloproliferative disease|myeloproliferative disorders]] | ||
*Colorectal carcinoma | *[[Colorectal carcinoma]] | ||
* | *[[Hepatocellular carcinoma (hepatoma)|Hepatocellular carcinoma]] | ||
*Renal cell carcinoma | *[[Renal cell carcinoma]] | ||
*carcinoma of CNS | *[[carcinoma of CNS]] | ||
*Sarcoma etc. | *[[Sarcoma]] etc. | ||
===Autoinflammatory/Rheumatologic=== | ===Autoinflammatory/Rheumatologic=== | ||
| Line 56: | Line 56: | ||
Examples include: | Examples include: | ||
*Systemic lupus erythematosus | *[[Systemic lupus erythematosus]] | ||
*Polymyositis | *[[Polymyositis]] | ||
*Dermatomyositis | *[[Dermatomyositis]] | ||
*Polymyalgia rheumatica etc. | *[[Polymyalgia rheumatica]] etc. | ||
| Line 67: | Line 67: | ||
Examples include: | Examples include: | ||
*Familial Mediterranean fever | *[[Familial mediterranean fever|Familial Mediterranean fever]] | ||
*Drug fever | *[[Drug fever]] | ||
*Thyroiditis | *[[Thyroiditis]] | ||
*Hypertriglyceridemia etc. | *[[Hypertriglyceridemia]] etc. | ||
==References== | ==References== | ||
Revision as of 21:00, 23 January 2021
|
Resident Survival Guide |
|
Fever of unknown origin Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Fever of unknown origin differential diagnosis On the Web |
|
American Roentgen Ray Society Images of Fever of unknown origin differential diagnosis |
|
Risk calculators and risk factors for Fever of unknown origin differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: febris continua e causa ignota; febris e causa ignota; febris E.C.I.; FUO; PUO; pyrexia of unknown origin
Overview
- Fever can be the presenting symptom with many diseases, it is therefore important to differentiate fever of unknown origin from all those diseases which present with fever.
- Because of the broad range of differential diagnosis they can be grouped into four categories based on their etiology.
- Infectious
- Malignant
- Inflammatory
- Miscellaneous[1]
Differential diagnosis
Infectious
These patients mostly have a history of hospitalization, surgical procedures, contact with infected person or travel to an endemic place.[2][3]
Examples include:
- Lyme disease
- Histoplasmosis
- Q fever
- Brucellosis
- Toxoplasmosis
- Leptospirosis
- Ehrlichiosis
- Anaplasmosis
- Tuberculosis
- Infectious mononucleosis
- mycobacterium avium infection etc.
Malignant
They are mostly accompanied by loss of weight, decrease in appetite, lymph node enlargement and aquagenic pruritic mostly occurring after hot shower.
Examples include:
- Hodgkin lymphoma
- myeloproliferative disorders
- Colorectal carcinoma
- Hepatocellular carcinoma
- Renal cell carcinoma
- carcinoma of CNS
- Sarcoma etc.
Autoinflammatory/Rheumatologic
Mostly they have multi organ involvement and lymphadenopathy along with joint symptoms may be present.[4][5]
Examples include:
Miscellaneous
Mostly does not belong to any of the above.
Examples include:
References
- ↑ Cunha, Burke A.; Lortholary, Olivier; Cunha, Cheston B. (2015). "Fever of Unknown Origin: A Clinical Approach". The American Journal of Medicine. 128 (10): 1138.e1–1138.e15. doi:10.1016/j.amjmed.2015.06.001. ISSN 0002-9343.
- ↑ Cunha, Burke A.; Lortholary, Olivier; Cunha, Cheston B. (2015). "Fever of Unknown Origin: A Clinical Approach". The American Journal of Medicine. 128 (10): 1138.e1–1138.e15. doi:10.1016/j.amjmed.2015.06.001. ISSN 0002-9343.
- ↑ Salzberger B, Schneidewind A, Hanses F, Birkenfeld G, Müller-Schilling M (2012). "[Fever of unknown origin. Infectious causes]". Internist (Berl). 53 (12): 1445–53, quiz 1454-5. doi:10.1007/s00108-012-3173-8. PMID 23111594.
- ↑ Kümmerle-Deschner JB (2017). "[Autoinflammatory Diseases as a Differential Diagnosis of Fever of Unknown Origin]". Dtsch Med Wochenschr. 142 (13): 969–978. doi:10.1055/s-0043-103468. PMID 28672419.
- ↑ Mulders-Manders CM, Simon A, Bleeker-Rovers CP (2016). "Rheumatologic diseases as the cause of fever of unknown origin". Best Pract Res Clin Rheumatol. 30 (5): 789–801. doi:10.1016/j.berh.2016.10.005. PMID 27964789.