Acute megakaryoblastic leukemia overview: Difference between revisions
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This rare subtype of AML was first reported in 1931 by Von Boros and his colleagues.<ref name="OkiKantarjian2006">{{cite journal|last1=Oki|first1=Yasuhiro|last2=Kantarjian|first2=Hagop M.|last3=Zhou|first3=Xian|last4=Cortes|first4=Jorge|last5=Faderl|first5=Stefan|last6=Verstovsek|first6=Srdan|last7=O'Brien|first7=Susan|last8=Koller|first8=Charles|last9=Beran|first9=Miloslav|last10=Bekele|first10=B. Nebiyou|last11=Pierce|first11=Sherry|last12=Thomas|first12=Deborah|last13=Ravandi|first13=Farhad|last14=Wierda|first14=William G.|last15=Giles|first15=Francis|last16=Ferrajoli|first16=Alessandra|last17=Jabbour|first17=Elias|last18=Keating|first18=Michael J.|last19=Bueso-Ramos|first19=Carlos E.|last20=Estey|first20=Elihu|last21=Garcia-Manero|first21=Guillermo|title=Adult acute megakaryocytic leukemia: an analysis of 37 patients treated at M.D. Anderson Cancer Center|journal=Blood|volume=107|issue=3|year=2006|pages=880–884|issn=0006-4971|doi=10.1182/blood-2005-06-2450}}</ref> | This rare subtype of AML was first reported in 1931 by Von Boros and his colleagues.<ref name="OkiKantarjian2006">{{cite journal|last1=Oki|first1=Yasuhiro|last2=Kantarjian|first2=Hagop M.|last3=Zhou|first3=Xian|last4=Cortes|first4=Jorge|last5=Faderl|first5=Stefan|last6=Verstovsek|first6=Srdan|last7=O'Brien|first7=Susan|last8=Koller|first8=Charles|last9=Beran|first9=Miloslav|last10=Bekele|first10=B. Nebiyou|last11=Pierce|first11=Sherry|last12=Thomas|first12=Deborah|last13=Ravandi|first13=Farhad|last14=Wierda|first14=William G.|last15=Giles|first15=Francis|last16=Ferrajoli|first16=Alessandra|last17=Jabbour|first17=Elias|last18=Keating|first18=Michael J.|last19=Bueso-Ramos|first19=Carlos E.|last20=Estey|first20=Elihu|last21=Garcia-Manero|first21=Guillermo|title=Adult acute megakaryocytic leukemia: an analysis of 37 patients treated at M.D. Anderson Cancer Center|journal=Blood|volume=107|issue=3|year=2006|pages=880–884|issn=0006-4971|doi=10.1182/blood-2005-06-2450}}</ref> | ||
It is classified under [[Acute_myelogenous_leukemia#French-American-British_classification|M7]] in the [[French-American-British classification]].<ref name="Bennett1985">{{cite journal|last1=Bennett|first1=John M.|title=Criteria for the Diagnosis of Acute Leukemia of Megakaryocyte Lineage (M7)|journal=Annals of Internal Medicine|volume=103|issue=3|year=1985|pages=460|issn=0003-4819|doi=10.7326/0003-4819-103-3-460}}</ref> | It is classified under [[Acute_myelogenous_leukemia#French-American-British_classification|M7]] in the [[French-American-British classification]].<ref name="Bennett1985">{{cite journal|last1=Bennett|first1=John M.|title=Criteria for the Diagnosis of Acute Leukemia of Megakaryocyte Lineage (M7)|journal=Annals of Internal Medicine|volume=103|issue=3|year=1985|pages=460|issn=0003-4819|doi=10.7326/0003-4819-103-3-460}}</ref> Subsequently, it was introduced in the WHO 2008 classification of myeloid neoplasms and acute leukemia.<ref name="VardimanThiele2009">{{cite journal|last1=Vardiman|first1=James W.|last2=Thiele|first2=Jüergen|last3=Arber|first3=Daniel A.|last4=Brunning|first4=Richard D.|last5=Borowitz|first5=Michael J.|last6=Porwit|first6=Anna|last7=Harris|first7=Nancy Lee|last8=Le Beau|first8=Michelle M.|last9=Hellström-Lindberg|first9=Eva|last10=Tefferi|first10=Ayalew|last11=Bloomfield|first11=Clara D.|title=The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes|journal=Blood|volume=114|issue=5|year=2009|pages=937–951|issn=0006-4971|doi=10.1182/blood-2009-03-209262}}</ref> | ||
In the first three years of life megakaryoblastic leukemia is the most common type of leukemia in patients with Downs syndrome.<ref>Hitzler JK. (2007) Acute megakaryoblastic leukemia in Down syndrome. Pediatr Blood Cancer. Dec;49(7 Suppl):1066-9. PMID: 17943965. </ref> | In the first three years of life megakaryoblastic leukemia is the most common type of leukemia in patients with Downs syndrome.<ref>Hitzler JK. (2007) Acute megakaryoblastic leukemia in Down syndrome. Pediatr Blood Cancer. Dec;49(7 Suppl):1066-9. PMID: 17943965. </ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Acute megakaryoblastic leukemia (AMKL) is a form of leukemia where a majority of the blasts are megakaryoblastic.[1]
This rare subtype of AML was first reported in 1931 by Von Boros and his colleagues.[2]
It is classified under M7 in the French-American-British classification.[3] Subsequently, it was introduced in the WHO 2008 classification of myeloid neoplasms and acute leukemia.[4]
In the first three years of life megakaryoblastic leukemia is the most common type of leukemia in patients with Downs syndrome.[5]
References
- ↑ "Final Diagnosis -- Case 439". Retrieved 2008-03-08.
- ↑ Oki, Yasuhiro; Kantarjian, Hagop M.; Zhou, Xian; Cortes, Jorge; Faderl, Stefan; Verstovsek, Srdan; O'Brien, Susan; Koller, Charles; Beran, Miloslav; Bekele, B. Nebiyou; Pierce, Sherry; Thomas, Deborah; Ravandi, Farhad; Wierda, William G.; Giles, Francis; Ferrajoli, Alessandra; Jabbour, Elias; Keating, Michael J.; Bueso-Ramos, Carlos E.; Estey, Elihu; Garcia-Manero, Guillermo (2006). "Adult acute megakaryocytic leukemia: an analysis of 37 patients treated at M.D. Anderson Cancer Center". Blood. 107 (3): 880–884. doi:10.1182/blood-2005-06-2450. ISSN 0006-4971.
- ↑ Bennett, John M. (1985). "Criteria for the Diagnosis of Acute Leukemia of Megakaryocyte Lineage (M7)". Annals of Internal Medicine. 103 (3): 460. doi:10.7326/0003-4819-103-3-460. ISSN 0003-4819.
- ↑ Vardiman, James W.; Thiele, Jüergen; Arber, Daniel A.; Brunning, Richard D.; Borowitz, Michael J.; Porwit, Anna; Harris, Nancy Lee; Le Beau, Michelle M.; Hellström-Lindberg, Eva; Tefferi, Ayalew; Bloomfield, Clara D. (2009). "The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes". Blood. 114 (5): 937–951. doi:10.1182/blood-2009-03-209262. ISSN 0006-4971.
- ↑ Hitzler JK. (2007) Acute megakaryoblastic leukemia in Down syndrome. Pediatr Blood Cancer. Dec;49(7 Suppl):1066-9. PMID: 17943965.