Haff disease laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: M. Hassan, M.B.B.S

Laboratory findings

Since Haff disease causes rhabdomyolysis, the approach to the evaluation of rhabdomyolysis should be as follows:

• CBC (complete blood count)
• Creatine kinase (three-five times the upper limit of normal values of 100 to 400 IU/L)
• Chemistries (hyperkalemia, hyperphosphatemia, and hypocalcemia)
• Liver function test
• Urine pH
• Urinalysis
  • Blood (+)
  • No red blood cells on microscopy (seen in either hemoglobinuria or myoglobinuria)

Currently, the following criteria is used to define cases of Haff disease:

1. A history of consumption of cooked fish within 24 hours prior to the onset of symptoms
2. Elevated serum creatine phosphokinase (more than fivefold)
3. CK-MB fraction of <5%