Allergic conjunctivitis pathophysiology: Difference between revisions
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The [[ocular]] [[allergic]] response is a cascade of events that is coordinated by [[mast cells]].<ref>{{cite journal | author = Liu G, Keane-Myers A, Miyazaki D, Tai A, Ono SJ | title = Molecular and cellular aspects of allergic conjunctivitis | journal = Chem. Immunol. | volume = 73 | pages = 39–58 | year = 1999 | pmid = 10590573 | doi = 10.1159/000058748 | series = Chemical Immunology and Allergy | isbn = 3-8055-6893-2 }}</ref> | The [[ocular]] [[allergic]] response is a cascade of events that is coordinated by [[mast cells]].<ref>{{cite journal | author = Liu G, Keane-Myers A, Miyazaki D, Tai A, Ono SJ | title = Molecular and cellular aspects of allergic conjunctivitis | journal = Chem. Immunol. | volume = 73 | pages = 39–58 | year = 1999 | pmid = 10590573 | doi = 10.1159/000058748 | series = Chemical Immunology and Allergy | isbn = 3-8055-6893-2 }}</ref> | ||
==[[Pathophysiology]]== | ==[[Pathophysiology]]== | ||
[[Allergic]] [[conjunctivitis]] is the manifestation of a predominantly [[IgE]]-mediated [[hypersensitivity]] reaction<ref name="pmid23497516">{{cite journal| author=La Rosa M, Lionetti E, Reibaldi M, Russo A, Longo A, Leonardi S | display-authors=etal| title=Allergic conjunctivitis: a comprehensive review of the literature. | journal=Ital J Pediatr | year= 2013 | volume= 39 | issue= | pages= 18 | pmid=23497516 | doi=10.1186/1824-7288-39-18 | pmc=3640929 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23497516 }} </ref>. | |||
Stimulated [[mast]] [[cells]] release increased amounts of [[tryptase]], [[histamine]], [[prostaglandins]] and [[leukotrienes]] in [[tears]]. This is the immediate response, which lasts for the initial 20-30 min. | |||
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==References== | ==References== | ||
Revision as of 17:14, 20 August 2022
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sujaya Chattopadhyay, M.D.[2]
Overview
The ocular allergic response is a cascade of events that is coordinated by mast cells.[1]
Pathophysiology
Allergic conjunctivitis is the manifestation of a predominantly IgE-mediated hypersensitivity reaction[2]. Stimulated mast cells release increased amounts of tryptase, histamine, prostaglandins and leukotrienes in tears. This is the immediate response, which lasts for the initial 20-30 min.
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References
- ↑ Liu G, Keane-Myers A, Miyazaki D, Tai A, Ono SJ (1999). "Molecular and cellular aspects of allergic conjunctivitis". Chem. Immunol. Chemical Immunology and Allergy. 73: 39–58. doi:10.1159/000058748. ISBN 3-8055-6893-2. PMID 10590573.
- ↑ La Rosa M, Lionetti E, Reibaldi M, Russo A, Longo A, Leonardi S; et al. (2013). "Allergic conjunctivitis: a comprehensive review of the literature". Ital J Pediatr. 39: 18. doi:10.1186/1824-7288-39-18. PMC 3640929. PMID 23497516.