Allergic conjunctivitis pathophysiology: Difference between revisions
| Line 6: | Line 6: | ||
==[[Pathophysiology]]== | ==[[Pathophysiology]]== | ||
[[Allergic]] [[conjunctivitis]] is the manifestation of a predominantly [[IgE]]-mediated [[hypersensitivity]] reaction<ref name="pmid23497516">{{cite journal| author=La Rosa M, Lionetti E, Reibaldi M, Russo A, Longo A, Leonardi S | display-authors=etal| title=Allergic conjunctivitis: a comprehensive review of the literature. | journal=Ital J Pediatr | year= 2013 | volume= 39 | issue= | pages= 18 | pmid=23497516 | doi=10.1186/1824-7288-39-18 | pmc=3640929 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23497516 }} </ref>. | [[Allergic]] [[conjunctivitis]] is the manifestation of a predominantly [[IgE]]-mediated [[hypersensitivity]] reaction<ref name="pmid23497516">{{cite journal| author=La Rosa M, Lionetti E, Reibaldi M, Russo A, Longo A, Leonardi S | display-authors=etal| title=Allergic conjunctivitis: a comprehensive review of the literature. | journal=Ital J Pediatr | year= 2013 | volume= 39 | issue= | pages= 18 | pmid=23497516 | doi=10.1186/1824-7288-39-18 | pmc=3640929 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23497516 }} </ref>. | ||
Stimulated [[mast]] [[cells]] release increased amounts of [[tryptase]], [[histamine]], [[prostaglandins]] and [[leukotrienes]] in [[tears]]. This is the immediate response, which lasts for the initial 20-30 min. | Stimulated [[mast]] [[cells]] release increased amounts of [[tryptase]], [[histamine]], [[prostaglandins]] and [[leukotrienes]] in [[tears]]. This is the immediate response, which lasts for the initial 20-30 min. | ||
↓ | |||
[[Degranulation]] of [[mast]] [[cells]] activates [[vascular]] [[endothelial]] [[cells]] to express [[adhesion]] molecules such as [[intercellular]] [[adhesion]] molecule ([[ICAM]]), [[vascular]] [[cell]] [[adhesion]] molecule ([[VCAM]]) and release [[chemokines]] like regulated upon activation normal [[T]] [[cells]] expressed and secreted ([[RANTES]]), [[monocyte]] [[chemoattractant]] [[protein]] ([[MCP]]), [[Interleukin]] (IL)-8, [[eotaxin]], [[macrophage]] [[inflammatory]] [[protein]] ([[MIP]])-1 alpha. | |||
↓ | ↓ | ||
Revision as of 17:21, 20 August 2022
|
Allergic conjunctivitis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Allergic conjunctivitis pathophysiology On the Web |
|
American Roentgen Ray Society Images of Allergic conjunctivitis pathophysiology |
|
Risk calculators and risk factors for Allergic conjunctivitis pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sujaya Chattopadhyay, M.D.[2]
Overview
The ocular allergic response is a cascade of events that is coordinated by mast cells.[1]
Pathophysiology
Allergic conjunctivitis is the manifestation of a predominantly IgE-mediated hypersensitivity reaction[2].
Stimulated mast cells release increased amounts of tryptase, histamine, prostaglandins and leukotrienes in tears. This is the immediate response, which lasts for the initial 20-30 min.
↓
Degranulation of mast cells activates vascular endothelial cells to express adhesion molecules such as intercellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM) and release chemokines like regulated upon activation normal T cells expressed and secreted (RANTES), monocyte chemoattractant protein (MCP), Interleukin (IL)-8, eotaxin, macrophage inflammatory protein (MIP)-1 alpha.
↓
References
- ↑ Liu G, Keane-Myers A, Miyazaki D, Tai A, Ono SJ (1999). "Molecular and cellular aspects of allergic conjunctivitis". Chem. Immunol. Chemical Immunology and Allergy. 73: 39–58. doi:10.1159/000058748. ISBN 3-8055-6893-2. PMID 10590573.
- ↑ La Rosa M, Lionetti E, Reibaldi M, Russo A, Longo A, Leonardi S; et al. (2013). "Allergic conjunctivitis: a comprehensive review of the literature". Ital J Pediatr. 39: 18. doi:10.1186/1824-7288-39-18. PMC 3640929. PMID 23497516.