Allergic conjunctivitis laboratory findings: Difference between revisions
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===[[Skin]] [[prick]] test=== | ===[[Skin]] [[prick]] test=== | ||
*[[Intradermal]] [[injections]] of [[individual allergens]] are administered to detect [[sensitivity]]<ref name="pmid23497516">{{cite journal| author=La Rosa M, Lionetti E, Reibaldi M, Russo A, Longo A, Leonardi S | display-authors=etal| title=Allergic conjunctivitis: a comprehensive review of the literature. | journal=Ital J Pediatr | year= 2013 | volume= 39 | issue= | pages= 18 | pmid=23497516 | doi=10.1186/1824-7288-39-18 | pmc=3640929 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23497516 }} </ref>. | *[[Intradermal]] [[injections]] of [[individual allergens]] are administered to detect [[sensitivity]]<ref name="pmid23497516">{{cite journal| author=La Rosa M, Lionetti E, Reibaldi M, Russo A, Longo A, Leonardi S | display-authors=etal| title=Allergic conjunctivitis: a comprehensive review of the literature. | journal=Ital J Pediatr | year= 2013 | volume= 39 | issue= | pages= 18 | pmid=23497516 | doi=10.1186/1824-7288-39-18 | pmc=3640929 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23497516 }} </ref>. | ||
* It is a highly sensitive test | * It is a highly sensitive test<ref name="pmid18431959">{{cite journal| author=Bernstein IL, Li JT, Bernstein DI, Hamilton R, Spector SL, Tan R | display-authors=etal| title=Allergy diagnostic testing: an updated practice parameter. | journal=Ann Allergy Asthma Immunol | year= 2008 | volume= 100 | issue= 3 Suppl 3 | pages= S1-148 | pmid=18431959 | doi=10.1016/s1081-1206(10)60305-5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18431959 }} </ref>. | ||
*The result is considered positive when the resulting [[wheal]] is at least 3 mm larger than the negative control. [[Systemic]] reactions are rare. | *The result is considered positive when the resulting [[wheal]] is at least 3 mm larger than the negative control. [[Systemic]] reactions are rare<ref name="pmid11167952">{{cite journal| author=Wilson AM, Orr LC, Sims EJ, Lipworth BJ| title=Effects of monotherapy with intra-nasal corticosteroid or combined oral histamine and leukotriene receptor antagonists in seasonal allergic rhinitis. | journal=Clin Exp Allergy | year= 2001 | volume= 31 | issue= 1 | pages= 61-8 | pmid=11167952 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11167952 }} </ref>. | ||
===[[IgE]] estimation=== | ===[[IgE]] estimation=== | ||
Revision as of 04:01, 30 August 2022
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Overview
Allergic conjunctivitis is usually a clinical diagnosis. Laboratory tests are primarily supportive. They may help in differentiating intrinsic and extrinsic forms of the condition and thus, guide the treatment.
Laboratory findings
Skin prick test
- Intradermal injections of individual allergens are administered to detect sensitivity[1].
- It is a highly sensitive test[2].
- The result is considered positive when the resulting wheal is at least 3 mm larger than the negative control. Systemic reactions are rare[3].
IgE estimation
In-vitro tests to detect IgE antibodies to specific allergens are widely used[4] if skin testing is indicated but not advised such as[5]:
- The patient cannot discontinue antihistaminic medications
- Ambiguous results (e.g., presence of dermatographism)
- To complement the results of previous skin testing.
References
- ↑ La Rosa M, Lionetti E, Reibaldi M, Russo A, Longo A, Leonardi S; et al. (2013). "Allergic conjunctivitis: a comprehensive review of the literature". Ital J Pediatr. 39: 18. doi:10.1186/1824-7288-39-18. PMC 3640929. PMID 23497516.
- ↑ Bernstein IL, Li JT, Bernstein DI, Hamilton R, Spector SL, Tan R; et al. (2008). "Allergy diagnostic testing: an updated practice parameter". Ann Allergy Asthma Immunol. 100 (3 Suppl 3): S1–148. doi:10.1016/s1081-1206(10)60305-5. PMID 18431959.
- ↑ Wilson AM, Orr LC, Sims EJ, Lipworth BJ (2001). "Effects of monotherapy with intra-nasal corticosteroid or combined oral histamine and leukotriene receptor antagonists in seasonal allergic rhinitis". Clin Exp Allergy. 31 (1): 61–8. PMID 11167952.
- ↑ Arasi S, Corsello G, Villani A, Pajno GB (2018). "The future outlook on allergen immunotherapy in children: 2018 and beyond". Ital J Pediatr. 44 (1): 80. doi:10.1186/s13052-018-0519-4. PMC 6042356. PMID 29996875.
- ↑ Dupuis P, Prokopich CL, Hynes A, Kim H (2020). "A contemporary look at allergic conjunctivitis". Allergy Asthma Clin Immunol. 16: 5. doi:10.1186/s13223-020-0403-9. PMC 6975089 Check
|pmc=value (help). PMID 31993069.