ABCC13: Difference between revisions

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{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Putative ATP-binding cassette transporter sub-family C member 13''' is a [[protein]] that in humans is encoded by the ''ABCC13'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ABCC13 ATP-binding cassette, sub-family C (CFTR/MRP), member 13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=150000| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = ATP-binding cassette, sub-family C (CFTR/MRP), member 13
| HGNCid = 16022
| Symbol = ABCC13
| AltSymbols =; C21orf73; PRED6
| OMIM = 608835
| ECnumber = 
| Homologene = 
| MGIid = 
| Function = {{GNF_GO|id=GO:0005524 |text = ATP binding}}{{GNF_GO|id=GO:0042626 |text = ATPase activity, coupled to transmembrane movement of substances}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 150000
    | Hs_Ensembl = 
    | Hs_RefseqProtein = 
    | Hs_RefseqmRNA = 
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
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{{CMG}}
__NOTOC__


== Function ==


==Overview==
This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described.<ref name="entrez"/>


'''ATP-binding cassette, sub-family C (CFTR/MRP), member 13''', also known as '''ABCC13''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ABCC13 ATP-binding cassette, sub-family C (CFTR/MRP), member 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=150000| accessdate = }}</ref>
== See also ==
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described.<ref name="entrez">{{cite web | title = Entrez Gene: ABCC13 ATP-binding cassette, sub-family C (CFTR/MRP), member 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=150000| accessdate = }}</ref>
}}
==See also==
* [[ATP-binding cassette transporter]]
* [[ATP-binding cassette transporter]]
* {{MeshName|ABCC13+protein,+human}}
* {{MeshName|ABCC13+protein,+human}}


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Dean M, Annilo T | title = Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates | journal = Annual Review of Genomics and Human Genetics | volume = 6 | issue =  | pages = 123–42 | year = 2005 | pmid = 16124856 | doi = 10.1146/annurev.genom.6.080604.162122 }}
| citations =
* {{cite journal | vauthors = Annilo T, Dean M | title = Degeneration of an ATP-binding cassette transporter gene, ABCC13, in different mammalian lineages | journal = Genomics | volume = 84 | issue = 1 | pages = 34–46 | date = Jul 2004 | pmid = 15203202 | doi = 10.1016/j.ygeno.2004.02.010 }}
*{{cite journal | author=Dean M, Annilo T |title=Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates. |journal=Annual review of genomics and human genetics |volume=6 |issue=  |pages= 123-42 |year= 2005 |pmid= 16124856 |doi= 10.1146/annurev.genom.6.080604.162122 }}
* {{cite journal | vauthors = Hillman RT, Green RE, Brenner SE | title = An unappreciated role for RNA surveillance | journal = Genome Biology | volume = 5 | issue = 2 | pages = R8 | year = 2005 | pmid = 14759258 | pmc = 395752 | doi = 10.1186/gb-2004-5-2-r8 }}
*{{cite journal | author=Annilo T, Dean M |title=Degeneration of an ATP-binding cassette transporter gene, ABCC13, in different mammalian lineages. |journal=Genomics |volume=84 |issue= 1 |pages= 34-46 |year= 2005 |pmid= 15203202 |doi= 10.1016/j.ygeno.2004.02.010 }}
* {{cite journal | vauthors = Brun ME, Ruault M, Ventura M, Roizès G, De Sario A | title = Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms | journal = Gene | volume = 312 | issue =  | pages = 41–50 | date = Jul 2003 | pmid = 12909339 | doi = 10.1016/S0378-1119(03)00530-4 }}
*{{cite journal | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8 }}
* {{cite journal | vauthors = Yabuuchi H, Takayanagi S, Yoshinaga K, Taniguchi N, Aburatani H, Ishikawa T | title = ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver | journal = Biochemical and Biophysical Research Communications | volume = 299 | issue = 3 | pages = 410–7 | date = Dec 2002 | pmid = 12445816 | doi = 10.1016/S0006-291X(02)02658-X }}
*{{cite journal | author=Brun ME, Ruault M, Ventura M, ''et al.'' |title=Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms. |journal=Gene |volume=312 |issue=  |pages= 41-50 |year= 2003 |pmid= 12909339 |doi= }}
* {{cite journal | vauthors = Gardiner K, Slavov D, Bechtel L, Davisson M | title = Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis | journal = Genomics | volume = 79 | issue = 6 | pages = 833–43 | date = Jun 2002 | pmid = 12036298 | doi = 10.1006/geno.2002.6782 }}
*{{cite journal | author=Yabuuchi H, Takayanagi S, Yoshinaga K, ''et al.'' |title=ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 3 |pages= 410-7 |year= 2003 |pmid= 12445816 |doi= }}
* {{cite journal | vauthors = Allikmets R, Gerrard B, Hutchinson A, Dean M | title = Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database | journal = Human Molecular Genetics | volume = 5 | issue = 10 | pages = 1649–55 | date = Oct 1996 | pmid = 8894702 | doi = 10.1093/hmg/5.10.1649 }}
*{{cite journal | author=Gardiner K, Slavov D, Bechtel L, Davisson M |title=Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. |journal=Genomics |volume=79 |issue= 6 |pages= 833-43 |year= 2002 |pmid= 12036298 |doi= 10.1006/geno.2002.6782 }}
*{{cite journal | author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
*{{cite journal  | author=Allikmets R, Gerrard B, Hutchinson A, Dean M |title=Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. |journal=Hum. Mol. Genet. |volume=5 |issue= 10 |pages= 1649-55 |year= 1997 |pmid= 8894702 |doi= }}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{ABC transporters}}
 
[[Category:ABC transporters]]
[[Category:ABC transporters]]


 
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Revision as of 06:28, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Putative ATP-binding cassette transporter sub-family C member 13 is a protein that in humans is encoded by the ABCC13 gene.[1]

Function

This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described.[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: ABCC13 ATP-binding cassette, sub-family C (CFTR/MRP), member 13".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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