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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''ATP-binding cassette sub-family F member 2''' is a [[protein]] that in humans is encoded by the ''ABCF2'' [[gene]].<ref name="pmid8894702">{{cite journal | vauthors = Allikmets R, Gerrard B, Hutchinson A, Dean M | title = Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database | journal = Human Molecular Genetics | volume = 5 | issue = 10 | pages = 1649–55 | date = October 1996 | pmid = 8894702 | pmc =  | doi = 10.1093/hmg/5.10.1649 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10061| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ATP-binding cassette, sub-family F (GCN20), member 2
| HGNCid = 71
| Symbol = ABCF2
| AltSymbols =; ABC28; DKFZp586K1823; EST133090; HUSSY-18; M-ABC1
| OMIM = 
| ECnumber = 
| Homologene = 21408
| MGIid = 1351657
| GeneAtlas_image1 = PBB_GE_ABCF2_207622_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ABCF2_207623_at_tn.png
| GeneAtlas_image3 = PBB_GE_ABCF2_209247_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}}
| Component = {{GNF_GO|id=GO:0005740 |text = mitochondrial envelope}} {{GNF_GO|id=GO:0043190 |text = ATP-binding cassette (ABC) transporter complex}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10061
    | Hs_Ensembl = ENSG00000033050
    | Hs_RefseqProtein = NP_005683
    | Hs_RefseqmRNA = NM_005692
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 150535856
    | Hs_GenLoc_end = 150555250
    | Hs_Uniprot = Q9UG63
    | Mm_EntrezGene = 27407
    | Mm_Ensembl = ENSMUSG00000028953
    | Mm_RefseqmRNA = NM_013853
    | Mm_RefseqProtein = NP_038881
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 24075408
    | Mm_GenLoc_end = 24087433
    | Mm_Uniprot = Q3UVI9
  }}
}}
'''ATP-binding cassette, sub-family F (GCN20), member 2''', also known as '''ABCF2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10061| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the superfamily of [[ATP-binding cassette]] (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This protein is a member of the GCN20 subfamily. [[Alternative splicing]] of this gene results in multiple transcript variants.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This protein is a member of the GCN20 subfamily. Alternative splicing of this gene results in multiple transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10061| accessdate = }}</ref>
}}


==See also==
ABCF2 acts as a suppressor of the volume-sensitive outwardly rectifying Cl  channel ([[CLCN3]]).<ref name="pmid22252987">{{cite journal | vauthors = Ando-Akatsuka Y, Shimizu T, Numata T, Okada Y | title = Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells | journal = Journal of Cellular Physiology | volume = 227 | issue = 10 | pages = 3498–510 | year = 2012 | pmid = 22252987 | doi = 10.1002/jcp.24050 }}</ref>
 
== See also ==
* [[ATP-binding cassette transporter]]
* [[ATP-binding cassette transporter]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Klein I, Sarkadi B, Váradi A | title = An inventory of the human ABC proteins | journal = Biochimica et Biophysica Acta | volume = 1461 | issue = 2 | pages = 237–62 | date = December 1999 | pmid = 10581359 | doi = 10.1016/s0005-2736(99)00161-3 }}
| citations =
* {{cite journal | vauthors = Dean M, Rzhetsky A, Allikmets R | title = The human ATP-binding cassette (ABC) transporter superfamily | journal = Genome Research | volume = 11 | issue = 7 | pages = 1156–66 | date = July 2001 | pmid = 11435397 | doi = 10.1101/gr.184901 }}
*{{cite journal | author=Klein I, Sarkadi B, Váradi A |title=An inventory of the human ABC proteins. |journal=Biochim. Biophys. Acta |volume=1461 |issue= 2 |pages= 237-62 |year= 2000 |pmid= 10581359 |doi= }}
* {{cite journal | vauthors = Hogue DL, Liu L, Ling V | title = Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein | journal = Journal of Molecular Biology | volume = 285 | issue = 1 | pages = 379–89 | date = January 1999 | pmid = 9878413 | doi = 10.1006/jmbi.1998.2259 }}
*{{cite journal | author=Dean M, Rzhetsky A, Allikmets R |title=The human ATP-binding cassette (ABC) transporter superfamily. |journal=Genome Res. |volume=11 |issue= 7 |pages= 1156-66 |year= 2001 |pmid= 11435397 |doi= 10.1101/gr.184901 }}
* {{cite journal | vauthors = Zhang F, Hogue DL, Liu L, Fisher CL, Hui D, Childs S, Ling V | title = M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein | journal = FEBS Letters | volume = 478 | issue = 1-2 | pages = 89–94 | date = July 2000 | pmid = 10922475 | doi = 10.1016/S0014-5793(00)01823-8 }}
*{{cite journal | author=Allikmets R, Gerrard B, Hutchinson A, Dean M |title=Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. |journal=Hum. Mol. Genet. |volume=5 |issue= 10 |pages= 1649-55 |year= 1997 |pmid= 8894702 |doi=  }}
* {{cite journal | vauthors = Ye Z, Connor JR | title = cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs | journal = Biochemical and Biophysical Research Communications | volume = 275 | issue = 1 | pages = 223–7 | date = August 2000 | pmid = 10944468 | doi = 10.1006/bbrc.2000.3282 }}
*{{cite journal  | author=Hogue DL, Liu L, Ling V |title=Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein. |journal=J. Mol. Biol. |volume=285 |issue= 1 |pages= 379-89 |year= 1999 |pmid= 9878413 |doi= 10.1006/jmbi.1998.2259 }}
* {{cite journal | vauthors = Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G | title = Characterization of 16 novel human genes showing high similarity to yeast sequences | journal = Yeast | volume = 18 | issue = 1 | pages = 69–80 | date = January 2001 | pmid = 11124703 | doi = 10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H }}
*{{cite journal | author=Zhang F, Hogue DL, Liu L, ''et al.'' |title=M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein. |journal=FEBS Lett. |volume=478 |issue= 1-2 |pages= 89-94 |year= 2000 |pmid= 10922475 |doi= }}
* {{cite journal | vauthors = Tsuda H, Ito YM, Ohashi Y, Wong KK, Hashiguchi Y, Welch WR, Berkowitz RS, Birrer MJ, Mok SC | title = Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses | journal = Clinical Cancer Research | volume = 11 | issue = 19 Pt 1 | pages = 6880–8 | date = October 2005 | pmid = 16203778 | doi = 10.1158/1078-0432.CCR-05-0751 }}
*{{cite journal | author=Ye Z, Connor JR |title=cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs. |journal=Biochem. Biophys. Res. Commun. |volume=275 |issue= 1 |pages= 223-7 |year= 2000 |pmid= 10944468 |doi= 10.1006/bbrc.2000.3282 }}
* {{cite journal | vauthors = Nishimura S, Tsuda H, Ito K, Jobo T, Yaegashi N, Inoue T, Sudo T, Berkowitz RS, Mok SC | title = Differential expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of different organs | journal = Human Pathology | volume = 38 | issue = 1 | pages = 134–9 | date = January 2007 | pmid = 16996567 | doi = 10.1016/j.humpath.2006.06.026 }}
*{{cite journal | author=Stanchi F, Bertocco E, Toppo S, ''et al.'' |title=Characterization of 16 novel human genes showing high similarity to yeast sequences. |journal=Yeast |volume=18 |issue= 1 |pages= 69-80 |year= 2001 |pmid= 11124703 |doi= 10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Tsuda H, Ito YM, Ohashi Y, ''et al.'' |title=Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses. |journal=Clin. Cancer Res. |volume=11 |issue= 19 Pt 1 |pages= 6880-8 |year= 2006 |pmid= 16203778 |doi= 10.1158/1078-0432.CCR-05-0751 }}
*{{cite journal | author=Nishimura S, Tsuda H, Ito K, ''et al.'' |title=Differential expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of different organs. |journal=Hum. Pathol. |volume=38 |issue= 1 |pages= 134-9 |year= 2007 |pmid= 16996567 |doi= 10.1016/j.humpath.2006.06.026 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|ABCF2+protein,+human}}
* {{MeshName|ABCF2+protein,+human}}
* {{UCSC genome browser|ABCF2}}
* {{UCSC gene details|ABCF2}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{ABC transporters}}
 
 
{{DEFAULTSORT:Abcf2}}
[[Category:ABC transporters]]
[[Category:ABC transporters]]
{{WikiDoc Sources}}
 
{{membrane-protein-stub}}

Revision as of 22:41, 4 December 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ATP-binding cassette sub-family F member 2 is a protein that in humans is encoded by the ABCF2 gene.[1][2]

Function

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This protein is a member of the GCN20 subfamily. Alternative splicing of this gene results in multiple transcript variants.[2]

ABCF2 acts as a suppressor of the volume-sensitive outwardly rectifying Cl channel (CLCN3).[3]

See also

References

  1. ↑ Allikmets R, Gerrard B, Hutchinson A, Dean M (October 1996). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Human Molecular Genetics. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.
  2. ↑ 2.0 2.1 "Entrez Gene: ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2".
  3. ↑ Ando-Akatsuka Y, Shimizu T, Numata T, Okada Y (2012). "Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells". Journal of Cellular Physiology. 227 (10): 3498–510. doi:10.1002/jcp.24050. PMID 22252987.

Further reading

  • Klein I, Sarkadi B, Váradi A (December 1999). "An inventory of the human ABC proteins". Biochimica et Biophysica Acta. 1461 (2): 237–62. doi:10.1016/s0005-2736(99)00161-3. PMID 10581359.
  • Dean M, Rzhetsky A, Allikmets R (July 2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Research. 11 (7): 1156–66. doi:10.1101/gr.184901. PMID 11435397.
  • Hogue DL, Liu L, Ling V (January 1999). "Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein". Journal of Molecular Biology. 285 (1): 379–89. doi:10.1006/jmbi.1998.2259. PMID 9878413.
  • Zhang F, Hogue DL, Liu L, Fisher CL, Hui D, Childs S, Ling V (July 2000). "M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein". FEBS Letters. 478 (1–2): 89–94. doi:10.1016/S0014-5793(00)01823-8. PMID 10922475.
  • Ye Z, Connor JR (August 2000). "cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs". Biochemical and Biophysical Research Communications. 275 (1): 223–7. doi:10.1006/bbrc.2000.3282. PMID 10944468.
  • Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (January 2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703.
  • Tsuda H, Ito YM, Ohashi Y, Wong KK, Hashiguchi Y, Welch WR, Berkowitz RS, Birrer MJ, Mok SC (October 2005). "Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses". Clinical Cancer Research. 11 (19 Pt 1): 6880–8. doi:10.1158/1078-0432.CCR-05-0751. PMID 16203778.
  • Nishimura S, Tsuda H, Ito K, Jobo T, Yaegashi N, Inoue T, Sudo T, Berkowitz RS, Mok SC (January 2007). "Differential expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of different organs". Human Pathology. 38 (1): 134–9. doi:10.1016/j.humpath.2006.06.026. PMID 16996567.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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